This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.
ERBB2IP; erbb2 interacting protein; protein LAP2; densin 180 like protein; ERBIN; LAP2; densin-180-like protein; ERBB2-interacting protein
ERBB2IP involved in several pathways and played different roles in them. We selected most pathways ERBB2IP participated on our site, such as NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERBB2IP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.