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FANCB

Official Full Name

Fanconi anemia, complementation group B
Overview

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein.
Synonyms

FANCB; Fanconi anemia, complementation group B; Fanconi anemia group B protein; FAAP95; FAB; FLJ34064; Fanconi anemia-associated polypeptide of 95 kDa; FA2; FACB; FAAP90;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Zebrafish

Source

In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FANCB-27930TH	Recombinant Human FANCB	Wheat Germ	N/A	109 amino acids	Inquiry
Human	FANCB-3826H	Recombinant Human FANCB Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FANCB-593HCL	Recombinant Human FANCB cell lysate		N/A		Inquiry
Human	FANCB-4663HF	Recombinant Full Length Human FANCB Protein, GST-tagged	In Vitro Cell Free System	GST	859 amino acids	Inquiry
Zebrafish	FANCB-3812Z	Recombinant Zebrafish FANCB	Mammalian Cell	His		Inquiry
Chicken	FANCB-4236C	Recombinant Chicken FANCB	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FANCB Related Articles

FANCB involved in several pathways and played different roles in them. We selected most pathways FANCB participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Fanconi anemia pathway	HER9;REV1;RAD51;TELO2;RPA3;FAN1;FUZ;WDR48;FANCE

FANCB has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCB itself. We selected most functions FANCB had, and list some proteins which have the same functions with FANCB. You can find most of the proteins on our site.

Function	Related Protein
protein binding	ZMYND10;SENP3;MOBKL1A;GAGE8;TRAF3IP1;KIF18A;LINC01588;SYNJ2;RIC8A

FANCB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCB here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCB.

FAAP100; Fancc; Faap100; FANCG; FANCA; FANCM; FANCL

Shapira, I; Scheiner, J; et al. FREQUENT SINGLE NUCLEOTIDE POLYMORPHISMS IN GERM LINE DNA OF CDK4, FANCB, FANCC AND MEN1 ARE SEEN IN BREAST CANCER PATIENTS. JOURNAL OF INVESTIGATIVE MEDICINE 63:584-584(2015).

Kim, TM; Son, MY; et al. RECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathway. NUCLEIC ACIDS RESEARCH 43:893-903(2015).