Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

FBXL6

Official Full Name

F-box and leucine-rich repeat protein 6
Overview

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.
Synonyms

FBXL6; F-box and leucine-rich repeat protein 6; F-box/LRR-repeat protein 6; FBL6; F box and leucine rich repeat protein 6; F box protein FBL 6; F box protein FBL6; F box/LRR repeat protein 6; FBL 6; FBL 6A; FBL6A; FbxL 6; PP 14630; PP14630; F-box protein Fbl6;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FBXL6-3909H	Recombinant Human FBXL6 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FBXL6-601HCL	Recombinant Human FBXL6 cell lysate		N/A		Inquiry
Human	FBXL6-5004HF	Recombinant Full Length Human FBXL6 Protein, GST-tagged	In Vitro Cell Free System	GST	539 amino acids	Inquiry
Mouse	FBXL6-5726M	Recombinant Mouse FBXL6 Protein	Mammalian Cell	His		Inquiry
Mouse	FBXL6-3150M	Recombinant Mouse FBXL6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	FBXL6-3150M-B	Recombinant Mouse FBXL6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
FBXL6 Related Articles

FBXL6 involved in several pathways and played different roles in them. We selected most pathways FBXL6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

FBXL6 has several biochemical functions, for example, contributes_to ubiquitin protein ligase activity, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL6 itself. We selected most functions FBXL6 had, and list some proteins which have the same functions with FBXL6. You can find most of the proteins on our site.

Function	Related Protein
contributes_to ubiquitin protein ligase activity	FBXL6;FBXL22;CUL1B;FBXL3B;KDM2BA;MED11;FBXL15;ANAPC2;SKP2
ubiquitin-protein transferase activity	UBE2D2;BIRC3;NHLRC1;BIRC5;MARCH5L;RNF10;RNF213;CBL;TRIM68

FBXL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL6.

SKP1; Srp72; UBE2A; Eif3e; HNRNPU; Naa50; Rpl35; Spire2; CAMKK1; GSG2; KBTBD7; TFG; NLRP3; MPHOSPH8; Rrbp1; Mad2l1bp; Cenph; Sart1

Hwang, CY; Kim, K; et al. Quantitative proteome analysis of age-related changes in mouse gastrocnemius muscle using mTRAQ. PROTEOMICS 14:121-132(2014).

Hu, TZ; Yang, YW; et al. Transgenic pepper plants carrying RNA interference constructs of CaCOI1 gene show severe abnormality. MOLECULAR BREEDING 31:971-979(2013).