FBXO18
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Official Full Name
F-box protein, helicase, 18
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Overview
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
FBXO18; F-box protein, helicase, 18; F box only protein 18; F-box only protein 18; FBH1; Fbx18; FLJ14590; F-box DNA helicase 1; F-box only protein, helicase, 18; MGC131916; MGC141935; MGC141937;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | FBXO18-28815TH | Recombinant Human FBXO18, His-tagged | E.coli | His |
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| Human | FBXO18-12787H | Recombinant Human FBXO18, His-tagged | E.coli | His | 693-1043a.a. | |
| Human | FBXO18-3911H | Recombinant Human FBXO18 protein, His-tagged | E.coli | His | 281-492 aa | |
| Zebrafish | FBXO18-4182Z | Recombinant Zebrafish FBXO18 | Mammalian Cell | His |
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| Chicken | FBXO18-3606C | Recombinant Chicken FBXO18 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
FBXO18 involved in several pathways and played different roles in them. We selected most pathways FBXO18 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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FBXO18 has several biochemical functions, for example, 3-5 DNA helicase activity, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO18 itself. We selected most functions FBXO18 had, and list some proteins which have the same functions with FBXO18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-5 DNA helicase activity | GINS1;FBXO18;CDC45;WRN;ERCC3 |
| ATP binding | HIPK3A;TARSL2;PTK2B;DDX6;GM7168;ACSBG2;UCK2B;MAPK11;GTF2F2 |
| ATP-dependent DNA helicase activity | ERCC2;G3BP1;WRN;CHD2;ERCC3;RUVBL2;XRCC6;BRIP1;DHX9 |
| DNA helicase activity | CHD8;MCM2;MCM6L;PIF1;WRN;MCM3;FBXO18;INO80;PEO1 |
| DNA translocase activity | RAD54B;ATRX;FBXO18 |
| double-stranded DNA binding | RBMS1;NKX2-8;MTERFD1;HMGB1;PIN4;HMGB2;XRCC6;IFI16;LSM14A |
| protein binding | TTC12;ELF4;SOX9A;MSH3;INCA1;UFD1L;CRCT1;CCDC42;KRTAP3-1 |
| single-stranded DNA binding | CDC45;SSBP2;XPC;TREX1;HNRNPK;NUP35;XRCC2;ANXA1;MLH3 |
FBXO18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO18 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO18.
HSP90AB1; SRC; RPL13A; ZDHHC17; PIM2; SYNCRIP; RALA; Nedd1; Rock1; PRR3; MRRF; ILKAP
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