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FBXO5

Official Full Name

F-box protein 5
Overview

Fbx5 (also known as F-box protein Fbx5, early mitotic inhibitor (Emi1), and F-box only protein 5) is a 44 kD nuclear protein containing an F-box. Fbx5 inhibits APC by binding to Cdc20 and promotes mitotic entry and cyclin A accumulation. Fbx5 is transcrip
Synonyms

FBXO5; F-box protein 5; F box only protein 5; F-box only protein 5; EMI1; FBX5; Fbxo31; F-box protein Fbx5; early mitotic inhibitor 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FBXO5-3957H	Recombinant Human FBXO5 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FBXO5-6290HCL	Recombinant Human FBXO5 293 Cell Lysate	HEK293	N/A		Inquiry
Human	FBXO5-4680HF	Recombinant Full Length Human FBXO5 Protein, GST-tagged	In Vitro Cell Free System	GST	447 amino acids	Inquiry
Mouse	FBXO5-5759M	Recombinant Mouse FBXO5 Protein	Mammalian Cell	His		Inquiry
Mouse	FBXO5-3173M	Recombinant Mouse FBXO5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	FBXO5-3173M-B	Recombinant Mouse FBXO5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	FBXO5-1156Z	Recombinant Zebrafish FBXO5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FBXO5 Related Articles

FBXO5 involved in several pathways and played different roles in them. We selected most pathways FBXO5 participated on our site, such as Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oocyte meiosis	CUL1B;CAMK2B;RPS6KA3;YWHAQA;PPP3CCA;ITPR1;PRKACBB;YWHAE2;PLK1

FBXO5 has several biochemical functions, for example, metal ion binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO5 itself. We selected most functions FBXO5 had, and list some proteins which have the same functions with FBXO5. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	ZMYND10;NEK2;TRPM6;RHEB;CHN1;ZBTB2A;ZNF398;ARL1;TKT
protein binding	ADAMTS5;KIAA0319L;EPCAM;NFKBIL1;MPP2;PAM16;FAM156A;RAP1GDS1;CLSTN1
protein kinase binding	HSP90AB1;SPRY2;MAP2K6;BAD;FGFR1OP;ARHGEF7;DUSP3;CCNL1A;MAP3K2

FBXO5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO5.

EVI5; CDC27; Cdc23; Cdc16; Cdc26; PLK1; TPM3; SKP1; ANAPC15

Haenold, R; Weih, F; et al. NF-kappa B controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS. JOURNAL OF CELL SCIENCE 127:3052-3065(2014).

Shoji, S; Muto, Y; et al. The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. FEBS OPEN BIO 4:689-703(2014).