• Official Full Name
  • four and a half LIM domains 1
  • Background
  • This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.
  • Synonyms
  • FHL1; four and a half LIM domains 1; four and a half LIM domains protein 1; bA535K18.1; FHL1B; FLH1A; KYO T; LIM protein SLIMMER; MGC111107; SLIM1; XMPMA; FHL 1; FHL 1B; FHL-1; FHL1 protein; FHL1_HUMAN; FHL1A; Four and a half Lin11 Isl 1 and Mec 3 domains 1; RAM14-1; RBP associated molecule 14-1; Skeletal muscle LIM protein 1; Skeletal muscle LIM-protein 1; SLIM 1; SLIM; SLIM-1; SLIMMER; OTTHUMP00000024097; OTTHUMP00000024098; OTTHUMP00000024099; OTTHUMP00000024100; OTTHUMP00000024101; OTTHUMP00000024102; OTTHUMP00000024103; OTTHUMP00000024104; OTTHUMP00000024106; OTTHUMP00000024107; skeleta; KYOT
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FHL1, GST-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human FHL1, MYC/DDK-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FHL1 protein, GST-tagged
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FHL1
Source (Host):Species:Human
Product nameRecombinant Human FHL1 293 Cell Lysate

Involved Pathway

FHL1 involved in several pathways and played different roles in them. We selected most pathways FHL1 participated on our site, such as Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Jak-STAT signaling pathway
IL12A; IL12RB1; STAT4; IL15; IL28RA; IFNA2; PIAS4; JAK2B; SOS1; Ifnl2

Protein Function

FHL1 has several biochemical functions, for example, ion channel binding, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FHL1 itself. We selected most functions FHL1 had, and list some proteins which have the same functions with FHL1. You can find most of the proteins on our site.
Related Protein
Function ion channel binding
Related Protein AKAP9; KCNAB1; HERPUD1; DIAPH1; KCNJ11; FYN; RNF207; SLC8A1; CALM1; FKBP1B
Function molecular_function
Related Protein LPAR6; TMTC4; D19WSU162E; OXR1; FITM1; FAM212AB; TMEM165; GM1987; OXNAD1; FAM65C
Function protein binding
Related Protein CBX8; SLC7A11; SALL4; GRASP; MOBKL2B; CYB561; IGFBP5; ECE1; CDA; HPRT1
Function zinc ion binding
Related Protein ADAM5P; TRIM16; WHSC1; SEC24D; OAS2; NEURL3; THRB; HDAC4; CAD; ING4

Interacting Protein

FHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FHL1.