fkbp4
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  • Official Full Name
  • FK506 binding protein 4, 59kDa
  • Background
  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
  • Synonyms
  • FKBP4; FK506 binding protein 4, 59kDa; HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase; peptidyl-prolyl cis-trans isomerase FKBP4; rotamase; HSP binding immunophilin; 51 kDa FK506-binding protein; FK506-binding protein 4 (59kD); T-cell FK506-binding protein, 59kD; peptidylprolyl cis-trans isomerase;
Cat.#:FKBP4-388HTag:His & PA
Source (Host):HEK293Species:Human
Product nameRecombinant Human FKBP4 Protein, His & PA-tagged
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Cat.#:FKBP4-4191HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FKBP4 Protein, GST-tagged
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Cat.#:FKBP4-1267HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FKBP4 protein, His & GST-tagged
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Cat.#:FKBP4-28339THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FKBP4, His-tagged
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Cat.#:FKBP4-796HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FKBP4 Protein, His-tagged
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Cat.#:FKBP4-5908MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FKBP4 Protein
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Cat.#:FKBP4-2355RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FKBP4 Protein
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Cat.#:FKBP4-1721RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FKBP4 Protein, His-tagged
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Cat.#:FKBP4-1397CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FKBP4
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Cat.#:FKBP4-11515ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FKBP4
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Cat.#:FKBP4-514HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FK506 Binding Protein 4, 59kDa, His-tagged
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Cat.#:FKBP4-6205HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FKBP4 293 Cell Lysate
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Involved Pathway

FKBP4 involved in several pathways and played different roles in them. We selected most pathways FKBP4 participated on our site, such as Estrogen signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Estrogen signaling pathway
GABBR2; PIK3CB; PIK3CD; MAPK1; PIK3CG; KCNJ3; FOS; HSPA1B; AKT2; SOS1

Protein Function

FKBP4 has several biochemical functions, for example, ATP binding, FK506 binding, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP4 itself. We selected most functions FKBP4 had, and list some proteins which have the same functions with FKBP4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RTEL1; CHUK; PMVK; EIF4A1B; PYGL; LIG1; MCM3; ITPKB; AK7A; FGFR1
Function FK506 binding
Related Protein FKBP1AB; FKBP11; TTC9C; FKBP6; FKBP5; FKBP9; FKBP14; FKBP4; FKBP1B; FKBPL
Function GTP binding
Related Protein RAB1B; ARL8; RAB25A; TUBA8L; TUBG1; RABL6; MXE; OLA1; URGCP; ARL13A
Function copper-dependent protein binding
Related Protein FKBP4; ATOX1; ATP7A
Function glucocorticoid receptor binding
Related Protein ETS2; NR4A2; EP300; GRIP1; YWHAH; CEBPB; FKBP4; STAT5B; STAT3; NRIP1
Function heat shock protein binding
Related Protein DNAJC9; BCOR; PDXP; LIMK1; DMPK; DNAJC7; NFKB1; HDAC2; PPID; SSUH2.2
Function peptidyl-prolyl cis-trans isomerase activity
Related Protein PPIL1; FKBP14; FKBP1AA; PPIL6; FKBP7; PPIH; FKBP11; PPIAB; PPIL4; FKBP1B
Function phosphoprotein binding
Related Protein LYN; DPYSL3; SERPINB1A; PRKCSH; YWHAB; CBX4; PLAT; PKD2; TBK1; PIH1D1
Function poly(A) RNA binding
Related Protein MAPRE1; ELAVL1; NKRF; MAGOHB; BICC1; KCTD12; RPL7A; MRPS26; RRP36; RIMS1
Function protein binding
Related Protein MRPS9; G0S2; FBXO4; TOB1A; KAT2A; NAA16; ZP3; RPS11; PKIA; MTNR1A
Function protein binding, bridging
Related Protein FKBP4; BCL3; FGB; TIRAP; ANK2; MEN1; ANXA1; CAV2; TRIM22; FLRT1
Function tau protein binding
Related Protein SNCA; PPP2R2A; AATF; DYRK1A; BIN1; APOE; FKBP4; HDAC6; SERPINB1A; S100B

Interacting Protein

FKBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP4.
S100a1; HSP90AA1; S100A6; S100A2