FKBP4 Protein, FK506 binding protein 4, 59kDa


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Official Full Name FK506 binding protein 4, 59kDa
Background The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
Synonyms FKBP4; FK506 binding protein 4, 59kDa; HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase; peptidyl-prolyl cis-trans isomerase FKBP4; rotamase; HSP binding immunophilin; 51 kDa FK506-binding protein; FK506-binding protein 4 (59kD); T-cell FK506-binding protein, 59kD; peptidylprolyl cis-trans isomerase;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • PA
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FKBP4-388H Recombinant Human FKBP4 protein, His/PA-tagged HEK293 His/PA
    Human FKBP4-1267H Recombinant Human FKBP4 protein, His & GST-tagged E.coli His/GST
    Human FKBP4-28339TH Recombinant Human FKBP4, His-tagged E.coli His
    Human FKBP4-4191H Recombinant Human FKBP4 Protein, GST-tagged Wheat Germ GST
    Human FKBP4-514H Recombinant Human FK506 Binding Protein 4, 59kDa, His-tagged E.coli His
    Human FKBP4-6205HCL Recombinant Human FKBP4 293 Cell Lysate HEK293 N/A
    Human FKBP4-796H Recombinant Human FKBP4 Protein, His-tagged E.coli His
    Mouse FKBP4-5908M Recombinant Mouse FKBP4 Protein Mammalian Cell His
    Rat FKBP4-2355R Recombinant Rat FKBP4 Protein Mammalian Cell His
    Rhesus Macaque FKBP4-1721R Recombinant Rhesus monkey FKBP4 Protein, His-tagged Mammalian Cell His
    Chicken FKBP4-1397C Recombinant Chicken FKBP4 Mammalian Cell His
    Zebrafish FKBP4-11515Z Recombinant Zebrafish FKBP4 Mammalian Cell His

    FKBP4 involved in several pathways and played different roles in them. We selected most pathways FKBP4 participated on our site, such as Estrogen signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Estrogen signaling pathway HRAS; CALM3; HSP90AB1; ITPR1; MAPK1; KRAS; GNAS; FOS; AKT2; PLCB4

    FKBP4 has several biochemical functions, for example, ATP binding, FK506 binding, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP4 itself. We selected most functions FKBP4 had, and list some proteins which have the same functions with FKBP4. You can find most of the proteins on our site.

    Function Related Protein
    FK506 binding FKBP4; FKBP10; NFATC1; FKBP1B; TTC9C; FKBP1AB; FKBP7; TTC9B; FKBP14; FKBP2
    copper-dependent protein binding ATOX1; FKBP4; ATP7A
    glucocorticoid receptor binding YWHAH; ETS2; CEBPB; EP300; NR4A2; NRIP1; FKBP4; STAT5B; GRIP1; STAT3
    heat shock protein binding HSPA1A; DMPK; PACRG; DNAJA2; IRAK1; NFKB1; DNAJA2L; BAX; DNAJC7; PPID
    peptidyl-prolyl cis-trans isomerase activity FKBP14; FKBP10; FKBP1AA; FKBPL; TTC9C; PPIH; PPID; PPIA; RANBP2; PPIL3
    phosphoprotein binding SRC; TBK1; PRKCSH; PKD2; YWHAB; MID1; SNCA; PIH1D1; URI1; YWHAE
    poly(A) RNA binding NME1; TRNAU1AP; CCDC55; EIF3D; ANKRD17; EXOSC8; NCBP2; SND1; MAPRE1; RPL23A
    protein binding FGF21; MATR3; SIN3B; ZWILCH; DNAJB6; PTPRC; DARS; RSPH1; ZFYVE27; FBXO27
    protein binding, bridging TJP2; FSCN1A; SH2D1B; NUFIP1; COL1A2; CSTA; FRMD4A; FSCN2A; CRADD; CNKSR1
    tau protein binding APOE; BIN1; S100B; HDAC6; DYRK1A; PPP2R2A; SERPINB1A; SNCA; FKBP4; AATF

    FKBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP4.

    S100a1; HSP90AA1; S100A6; S100A2

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