foxm1
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  • Official Full Name
  • forkhead box M1
  • Background
  • The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
  • Synonyms
  • FOXM1; forkhead box M1; MPP2; TGT3; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1B; HFH-11; TRIDENT; MPHOSPH2; forkhead box protein M1; M-phase phosphoprotein 2; HNF-3/fork-head homolog 11; transcription factor Trident; MPM-2 reactive phosphoprotein 2; forkhead-related protein FKHL16; winged-helix factor from INS-1 cells; Forkhead, drosophila, homolog-like 16; hepatocyte nuclear factor 3 forkhead homolog 11;
Cat.#:FOXM1-1215HTag:His|SUMO|Myc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOXM1 Protein, His-SUMO/MYC-tagged
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Cat.#:FOXM1-2560HTag:GST|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FOXM1 Protein, GST/His-tagged
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Cat.#:FOXM1-4464HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FOXM1 Protein, GST-tagged
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Cat.#:Foxm1-7640RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Foxm1 protein, His & T7-tagged
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Cat.#:FOXM1-2166CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FOXM1
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Cat.#:FOXM1-11319ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FOXM1
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Cat.#:FOXM1-6152HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FOXM1 293 Cell Lysate
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Cat.#:FOXM1-6153HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FOXM1 293 Cell Lysate
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Involved Pathway

FOXM1 involved in several pathways and played different roles in them. We selected most pathways FOXM1 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1 associated events during G2/M transition, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
RBBP7; ANAPC13; DIDO1; PRKDC; CTDNEP1A; CDC26; MIS12; HAUS2; TUBGCP5; TUBB4A
Cell Cycle, Mitotic
STAG1; TCTN2; CENPK; LIN9; NCAPG; CNEP1R1; CKS1B; TUBGCP5; CDKN2A; SMC4
Cyclin A/B1 associated events during G2/M transition
CDK7; FOXM1
FOXM1 transcription factor network
AURKB; CENPA; CHEK2; FOXM1; CENPB; CKS1B
G2/M Transition
CDK11A; CEP57; FOXM1; DCTN1A; TUBGCP3; NUMA1; TUBGCP2; CEP63; CEP78; CEP135
Mitotic G2-G2/M phases
CDK11A; CDK11B; LIN52; TUBGCP2; TUBGCP3; LIN37; LIN9; BORA; TUBGCP4; FOXM1
Polo-like kinase mediated events
LIN9; LIN37; LIN52; FOXM1
SIDS Susceptibility Pathways
TPH2; TSPYL1; TAC1; CHRFAM7A; SNTA1; POU3F2; LMX1B; ECE1; TPPP; PLP1

Protein Function

FOXM1 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXM1 itself. We selected most functions FOXM1 had, and list some proteins which have the same functions with FOXM1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZBED6; TGIF2; ZNF615; SMAD6A; FOXQ2; PROX1; NR5A5; DRAP1; APEX1; HIF1AL2
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein FOXG1D; ETV4; PAX6A; FOXP3A; FOXD4; ETV2; ERG; ELF5; SP1; ZNF174
Function protein binding
Related Protein NRF1; NLRP3; KCNA1; ZNF187; KLC2; ZBTB9; SMNDC1; PHC2; CST9L; CHCHD6
Function protein kinase binding
Related Protein SUFU; NSF; TUBB3; SFN; USP37; PGAM1; RPTOR; SPAG16; SV2A; PLCG1
Function sequence-specific DNA binding
Related Protein RXRAB; FOSL1A; FOXC1A; GSX1; NR2E3; NR1D1; DBX1; ETV5B; SHOX2; ZNF396
Function transcription factor activity, sequence-specific DNA binding
Related Protein TCF7L2; CTBP1; ZFP354C; CARF; FOSL1; ELF1; HES6; GRHL2A; NR2F5; NR2F6A
Function transcription regulatory region DNA binding
Related Protein TAF9; TBL1XR1; WNT11; MLL1; CREB3L2; SALL2; ASH2L; ZFP382; ZFP746; IKZF4

Interacting Protein

FOXM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXM1.
CTNNB1; TCF7L2

FOXM1 Related Articles

Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).
Sanabria-Figueroa, E; Donnelly, SM; et al. Insulin-Like Growth Factor-1 Receptor Signaling Increases the Invasive Potential of Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Cells via Src-Focal Adhesion Kinase and Forkhead Box Protein M1. MOLECULAR PHARMACOLOGY 87:150-161(2015).