FOXO3 Protein, forkhead box O3

FOXO3

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FOXO3

Official Full Name forkhead box O3
Background This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Synonyms FOXO3; forkhead box O3; FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2; forkhead box protein O3; forkhead box O3A; forkhead in rhabdomyosarcoma-like 1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FOXO3-28110TH Recombinant Human FOXO3 Wheat Germ N/A
    Human FOXO3-2811H Recombinant Human FOXO3, MYC/DDK-tagged HEK293 Myc/DDK
    Human FOXO3-4471H Recombinant Human FOXO3 Protein, GST-tagged Wheat Germ GST
    Human FOXO3-6148HCL Recombinant Human FOXO3 293 Cell Lysate HEK293 N/A
    Human FOXO3-7633H Recombinant Human FOXO3 protein, His & T7-tagged E.coli His/T7
    Mouse FOXO3-6007M Recombinant Mouse FOXO3 Protein Mammalian Cell His
    Kit-1650 FOXO3 Nuclear Translocation Assay Kit N/A

    FOXO3 involved in several pathways and played different roles in them. We selected most pathways FOXO3 participated on our site, such as Chemokine signaling pathway, FoxO signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine signaling pathway PAK1; CXCR3; CCL6; KRAS; GNG8; IKBKB; BRAF; CDC42; CXCL3; CCL3
    FoxO signaling pathway CCNB2; IGF1; SOD2; G6PC2; G6PCA.2; FOXO3B; FOXO4; BCL6; USP7; BRAF
    PIK-Akt signaling pathway PCK1; PHLPP1; PPP2R3A; FN1; IFNA8; TLR2; IFNA10; FGF6; HSP90B1; GYS2
    AMPK signaling pathway PIK3CG; MLYCD; PRKAB2; SCD5; MTOR; RAB8A; CCNA2; PIK3CA; PIK3R2; PIK3R1
    Neurotrophin signaling pathway BDNF; SHC1; ZFP110; CDC42; MAPK10; NGFR; NGFRAP1; NRAS; MAPK7; PIK3R1
    Prolactin signaling pathway FOXO3; CCND2; MAPK3; MAPK13; CSH; PIK3CD; SOS1; SOCS4; PPIB; RAF1
    Endometrial cancer ARAF; TCF7L2; PIK3CB; PIK3R3; BAD; AKT2; PIK3CA; AKT1; RAF1; TP53
    Non-small cell lung cancer PRKCA; AKT2; PIK3R5; PLCG1; RASSF5; MAP2K1; ERBB2; GRB2; STK4; PLCG2

    FOXO3 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXO3 itself. We selected most functions FOXO3 had, and list some proteins which have the same functions with FOXO3. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding NR2C1; MYO18A; THAP7; CCDC71L; DMBX1; PBRM1; ZNF443; ESR2; TSN; ZFP2
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FOXI3A; ATF4B1; ZNF131; SOX21A; ZNF202; HOXA13B; HIF3A; ZNF576; FOXA1; TFDP1B
    chromatin DNA binding THRB; SRF; H2AFY2; HIST1H1E; INSM1B; VAX2; H1F0; WBP2; GATA1; H2AFZ
    core promoter binding FOXP3; CCAR1; INSM1A; KLF4; E2F7; PYDC3; NEUROG3; MTA1; IFI203; E2F3
    protein binding AMBP; RYK; AKAP13; CHMP2A; HIPK4; ZZZ3; TRPC6; TMED10; GNB2; PPARGC1A
    protein kinase binding CDKN2C; ADRA2A; ELP2; PRKAG3; PRKAB1; RHOD; DLG1L; AP2A2; TRAF4; C10orf46
    sequence-specific DNA binding FOXL2; HOXC9A; SALL1A; PPARA; BPTF; DBPB; NOTCH1; ZBTB4; E2F5; KLF5
    transcription cofactor binding CHD6; KLF4; FOXO3; TRP53
    transcription factor activity, sequence-specific DNA binding DMRTC1B; FLI1B; HOXA13; TCF19; WT1B; MAFA; FOXO4; SOX6; TAF13; ZFP518A
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding PPARG; BHLHA15; GRHL2; MAFA; ELF5; ALX1; NEUROD2; CSRNP1; ATF5; NR1I3
    transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DMBX1; BCL6A; ASCL3; CDX2; HOXD9; AEBP1; ETV6; PCGF6; ZNF350; ESX1

    FOXO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXO3.

    SIRT1; TP53; SMAD4; YWHAB; YWHAH; YWHAZ; PPP2R1A

    Haas, MJ; Onstead-Haas, L; et al. The Effect of Black Seed (Nigella sativa) Extract on FOXO3 Expression in HepG2 Cells. PHYTOTHERAPY RESEARCH 28:873-879(2014).
    Tikhanovich, I; Kuravi, S; et al. Regulation of FOXO3 by Phosphorylation and Methylation in Hepatitis C Virus Infection and Alcohol Exposure. HEPATOLOGY 59:58-70(2014).

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