frs2
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  • Official Full Name
  • fibroblast growth factor receptor substrate 2
  • Background
  • Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.
  • Synonyms
  • FRS2; fibroblast growth factor receptor substrate 2; FRS2A; FRS2alpha; SNT 1; SNT1; FGFR signaling adaptor SNT; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; FRS 2; FRS2_HUMAN; SNT; SNT-1; Suc 1 Associated Neurotrophic Factor Target; Suc1 associated neurotrophic factor target 1; Suc1-associated neurotrophic factor target 1
Cat.#:FRS2-4506HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FRS2 Protein, GST-tagged
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Cat.#:Frs2-191MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Frs2 Protein, His-tagged
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Cat.#:Frs2-192RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Frs2 Protein, His-tagged
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Cat.#:FRS2-22HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FRS2 protein, His-tagged
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Cat.#:FRS2-23HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FRS2 protein, MYC/DDK-tagged
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Cat.#:FRS2-28951THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FRS2
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Cat.#:FRS2-6048MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FRS2 Protein
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Cat.#:FRS2-4430CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FRS2
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Cat.#:FRS2-6134HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FRS2 293 Cell Lysate
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Involved Pathway

FRS2 involved in several pathways and played different roles in them. We selected most pathways FRS2 participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FRS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ARMS-mediated activation
NEFLB; DUSP2; NRG4; SPRED3; PAQR3A; DLG4; DUSP7; SPTBN2; IL17RD; PSMD9
Adaptive Immune System
KIF22; UBE2E3; OSCAR; FGF8B; PJA2; FAM49BA; RAP1GAP2B; CD300A; KLRB1B; RAP1GAP2
Axon guidance
EFNB2A; SEMA3A; EFNB1; RNF8; PLXNC1; EPHB1; RASA1; DPYSL2; EFNA4; SEMA4C
BDNF signaling pathway
EGR2; FRS2; KCNN2; DOK5; JAK2; CDKL5; SIRPA; BCL2L11; MAP3K2; GRIP1
Constitutive Signaling by Aberrant PI3K in Cancer
FRS2; NRG3; EGF; KLB; HBEGF; NRG4; TRAT1
Cytokine Signaling in Immune system
EDAR; PELI1; EDA; PELI3; GBP1; IFITM2; SPNA1; TRIM2; TRIM10; PHB
DAP12 interactions
FRS2B; JAK1; AGO1; SPRED3; AGO2; KIR3DS1; DUSP7; PRKAR1AA; AHCYL1; PAQR3B
DAP12 signaling
NEFLB; AGO3; SPTB; HBEGF; NRG4; AGO2; SPNA1; FGFR1B; PRKAR1AA; FGF18B

Protein Function

FRS2 has several biochemical functions, for example, fibroblast growth factor receptor binding, insulin receptor binding, neurotrophin TRKA receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FRS2 itself. We selected most functions FRS2 had, and list some proteins which have the same functions with FRS2. You can find most of the proteins on our site.
Function
Related Protein
Function fibroblast growth factor receptor binding
Related Protein FGF20; FGF1A; FGF10; FGF4; FGF8B; FGF10B; FGF8A; FRS3; FGF16; FGF10A
Function insulin receptor binding
Related Protein DOK4; INSL3; PIK3R1; INS2; IGF1; PTPN11; DOK6; FRS2A; DOK5; PDPK1
Function neurotrophin TRKA receptor binding
Related Protein PLCG1; SHC1; NGFR; PIK3R1; GRB2; EFNA5; FRS2
Function phosphatase activator activity
Related Protein GTF2F1; BMP2; FRS2
Function protein binding
Related Protein POLD4; CHD4; TBC1D5; SMAD3A; MAPK1; ZNF167; KLF4; HIST1H2AM; NITR9; OLR1
Function transmembrane receptor protein tyrosine kinase adaptor activity
Related Protein SH2B2; STAP1; SHC1; PIK3R1; FRS2; BLNK; DOK2; GAB2; IRS1; TRAT1

Interacting Protein

FRS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FRS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FRS2.
PTPN11; RPS6; BECN1; suc1; FGFR1; GRB2; SH2B1; Coro1c

FRS2 Related Articles

Issa, A; Gill, JW; et al. Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models. BREAST CANCER RESEARCH 15:-(2013).
Hisaoka, K; Tsuchioka, M; et al. Tricyclic Antidepressant Amitriptyline Activates Fibroblast Growth Factor Receptor Signaling in Glial Cells INVOLVEMENT IN GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR PRODUCTION. JOURNAL OF BIOLOGICAL CHEMISTRY 286:21118-21128(2011).

FRS2 Related Gene Family

TGF