gmnn
Share
  • Official Full Name
  • geminin, DNA replication inhibitor
  • Background
  • GMNN inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
  • Synonyms
  • GMNN; geminin, DNA replication inhibitor; geminin; Gem
Cat.#:GMNN-5014HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GMNN Protein, GST-tagged
+Inquiry
Cat.#:GMNN-353HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Geminin, DNA Replication Inhibitor, His-tagged
+Inquiry
Cat.#:GMNN-13336HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GMNN, GST-tagged
+Inquiry
Cat.#:GMNN-28741THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GMNN protein, His-tagged
+Inquiry
Cat.#:GMNN-29013THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GMNN, His-tagged
+Inquiry
Cat.#:GMNN-7837HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GMNN protein, His & GST-tagged
+Inquiry
Cat.#:GMNN-7004MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GMNN Protein
+Inquiry
Cat.#:Gmnn-7838MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gmnn protein, His & GST-tagged
+Inquiry
Cat.#:Gmnn-7839RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gmnn protein, His & T7-tagged
+Inquiry
Cat.#:GMNN-1885RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GMNN Protein, His-tagged
+Inquiry
Cat.#:GMNN-2691CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GMNN
+Inquiry
Cat.#:GMNN-10439ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GMNN
+Inquiry
Cat.#:GMNN-5880HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GMNN 293 Cell Lysate
+Inquiry

Involved Pathway

GMNN involved in several pathways and played different roles in them. We selected most pathways GMNN participated on our site, such as Assembly of the pre-replicative complex, Association of licensing factors with the pre-replicative complex, CDT1 association with the CDC6:ORC:origin complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with GMNN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of the pre-replicative complex
MCM8; CDT1; E2F1; E2F3; GMNN; E2F2
Association of licensing factors with the pre-replicative complex
E2F2; E2F3; CDT1; E2F1; GMNN
CDT1 association with the CDC6:ORC:origin complex
GMNN; CDT1; MCM8
Cell Cycle
KIF18A; RBBP4; BARD1; RUVBL2; TMEM188; ANAPC2; PCM1; SET; CSNK2A1; DSN1
Cell Cycle, Mitotic
SMC4; ARPP19B; CSNK2A1; NIPBL; GINS4; CENPP; CSNK2A2; MLF1IP; ACTR1A; MAPRE1
DNA Replication
RPA1; MCM2; MCM7; SSBP1; POLE; RNASEH2A; POLE3; GINS1; POLD1; GINS3
DNA Replication Pre-Initiation
GMNN; DBF4; MCM10; CDT1
M/G1 Transition
GMNN

Protein Function

GMNN has several biochemical functions, for example, histone deacetylase binding, protein binding, repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GMNN itself. We selected most functions GMNN had, and list some proteins which have the same functions with GMNN. You can find most of the proteins on our site.
Function
Related Protein
Function histone deacetylase binding
Related Protein BRMS1; RELA; HIST1H1B; SFPQ; YWHAE; SP1; MAPK8; TAL1; ZNHIT1; KPNA2
Function protein binding
Related Protein PVRL4; TMEM41A; AP5Z1; CSTF3; FAAH; POLB; YIPF2; SERPINC1; CD97; SNRPD3
Function repressing transcription factor binding
Related Protein HDAC9; PRDM5; HMGB1; PARK7; RELA; HHEX; MYC; SKI; NFYB; CBX5
Function transcription corepressor activity
Related Protein ATF5; CIR1; PIAS1; MYBBP1A; CCAR1; SIAH2; TRIM28; CCND1; UBP1; KCNIP3

Interacting Protein

GMNN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GMNN here. Most of them are supplied by our site. Hope this information will be useful for your research of GMNN.
CDT1; MCIDAS; CCDC146