gnb3
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  • Official Full Name
  • guanine nucleotide binding protein (G protein), beta polypeptide 3
  • Background
  • G-Protein b3 (GNB3) is a guanine nucleotide-binding protein (G protein). G-proteins are involved as a modulator or transducer in various transmembrane signaling systems.
  • Synonyms
  • GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; transducin beta chain 3; G protein, beta-3 subunit; hypertension associated protein; GTP-binding regulatory protein
Cat.#:GNB3-5056HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GNB3 Protein, GST-tagged
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Cat.#:GNB3-299HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human guanine nucleotide binding protein (G protein), beta polypeptide 3, His-tagged
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Cat.#:GNB3-2602RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GNB3 Protein
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Cat.#:GNB3-1898RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GNB3 Protein, His-tagged
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Cat.#:GNB3-5861HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GNB3 293 Cell Lysate
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Involved Pathway

GNB3 involved in several pathways and played different roles in them. We selected most pathways GNB3 participated on our site, such as Ras signaling pathway, Chemokine signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
FGF7; GNG7; MRAS; PLA2G3; KSR2; PTPN11; FGF19; CALML5; RAC1; CALM3
Chemokine signaling pathway
CCL21; FGR; Ccl21a; ADRBK1; RAP1B; CCR8; CRKL; RAC1; PIK3CA; STAT5B
PIK-Akt signaling pathway
YWHAB; GNG8; PPP2R2B; PTK2; IFNA5; ITGB7; LAMB1; FGF16; Itga10&Itgb1; KLK1B4
Circadian entrainment
GNG11; CAMK2A; ITPR3; CAMK2G; GNG10; GNG13; AKR1C1; PRKACB; GNG4; PLCB3
Retrograde endocannabinoid signaling
GRIA3; GABRA2; GABRB3; GNB1; GNGT1; GABRA5; MAPK3; GABRG2; PRKCB; MAPK13
Glutamatergic synapse
ITPR3; PPP3R1; PPP3R2; GNAS; GNB1; TRPC1; PPP3CB; GNAQ; GNB3; ITPR1
Cholinergic synapse
GNG5; PIK3CA; GNGT1; GNAI3; CHRNA6; PRKACB; PIK3CG; PIK3CB; CREB5; GNA11
Serotonergic synapse
GNG2; SLC6A4; HTR3C; ITPR3; PTGS2; CYP2C39; ALOX8; PLCB2; HTR1E; MAPK1
GABAergic synapse
GABARAPL1; GNG2; GABRG3; GABRA2; GABRA6; SLC6A1; GNG5; PRKACA; GNB2; GABARAP
Dopaminergic synapse
KCNJ3; GRIA2; GSK3A; GNG5; GNAO1; GNG4; CALM2; KCNJ9; GNAL; SLC6A3
Taste transduction
ASIC2; TAS1R2; TAS2R134; GNG13; PRKACB; TAS2R120; TAS2R113; TAS2R137; TAS2R124; GNAT3
Morphine addiction
PDE2A; GABRR1; GABRG3; GABRE; GNG10; PDE7B; GABRB1; PDE3B; GNB1; PDE8B
Alcoholism
GNG4; PRKACA; GNB3; CREB5; MAPK3; HIST1H2BG; HIST1H2BK; HDAC6; H2AFJ; HIST1H4L
Pathways in cancer
TCEB2; PML; MSH6; EGLN3; WNT2B; MSH2; PTCH1; TRP53; WNT9B; AXIN2

Protein Function

GNB3 has several biochemical functions, for example, GTPase activity, GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB3 itself. We selected most functions GNB3 had, and list some proteins which have the same functions with GNB3. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activity
Related Protein GTPBP4; RHOG; RHOT1; GNA15.1; TUBA1A; RASEF; GNAS; RAB20; SRPR; TUBB4B
Function GTPase binding
Related Protein SH3GL1; GM5506; RASA1; RAB3D; AIMP1; PTPRN; HSP90AA1; GNB3; LCP1; BNIP3
Function protein binding
Related Protein ADRA2A; TUBB4A; KRTAP19-5; DOLK; STX12; ROBO2; DNER; HP1BP3; CLPTM1; CDK4
Function signal transducer activity
Related Protein LSP1; STAT5A; PLCH2; GPR126; OPN4.1; ACKR3B; TAS2R117; GNG4; GNGT2B; GNA15.1

Interacting Protein

GNB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB3.
CXCR5; NS; ERBB2; P; ESR2; CDC5L