Recombinant Full Length Human GNB3 Protein, GST-tagged

• Cat.No.: GNB3-5370HF
• Product Overview: Human GNB3 full-length ORF ( AAH02454, 1 a.a. - 340 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 63.14 kDa
• Protein Length: 340 amino acids
• AA Sequence: MGEMEQLRQEAEQLKKQIADARKAC AGVTLAELVSGLEVVGRVQMRTRRT LRGHLAKIYAMHWATDSKLLVSASQ DGKLIVWDSYTTNKVHAIPLRSSWV MTCAYAPSGNFVACGGLDNMCSIYN LKSREGNVKVSRELSAHTGYLSCCR FLDDNNIVTSSGDTTCALWDIETGQ QKTVFVGHTGDCMSLAVSPDFNLFI SGACDASAKLWDVREGTCRQTFTGH ESDINAICFFPNGEAICTGSDDASC RLFDLRADQELICFSHESIICSITS VAFSLSGRLLFAGYDDFNCNVWDSM KSERVGILSGHDNRVSCLGVTADGM AVATGSWDSFLKIWN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 [ Homo sapiens ]
• Official Symbol: GNB3
• Synonyms: GNB3; guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; transducin beta chain 3; G protein, beta-3 subunit; hypertension associated protein; GTP-binding regulatory protein beta-3 chain; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3
• Gene ID: 2784
• mRNA Refseq: NM_002075
• Protein Refseq: NP_002066
• MIM: 139130
• UniProt ID: P16520