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GNGT1

Official Full Name

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
Overview

Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by;transmembrane receptors to effector proteins. Transducin is a guanine nucleotide-binding protein found specifically in;rod outer segments, where it mediates activation by rhodopsin of a cyclic GTP-specific (guanosine monophosphate);phosphodiesterase. Transducin is also referred to as GMPase. GNGT1 encodes the gamma subunit of transducin (Hurley et;al., 1984 (PubMed 6438626); Scherer et al., 1996 (PubMed 8661128)).
Synonyms

GNGT1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1; guanine nucleotide-binding protein G(T) subunit gamma-T1; GNG1; G gamma 1; Guanine nucleotide binding protein G; Transducin gamma chain;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
MYC
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GNGT1-571H	Recombinant Human GNGT1 Protein, His-tagged	E.coli	His		Inquiry
Human	GNGT1-722HCL	Recombinant Human GNGT1 cell lysate		N/A		Inquiry
Human	GNGT1-1947H	Recombinant Human GNGT1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	GNGT1-5393HF	Recombinant Full Length Human GNGT1 Protein, GST-tagged	In Vitro Cell Free System	GST	74 amino acids	Inquiry
Human	GNGT1-5076H	Recombinant Human GNGT1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GNGT1-3487H	Recombinant Human GNGT1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	GNGT1-7042M	Recombinant Mouse GNGT1 Protein	Mammalian Cell	His		Inquiry
Mouse	GNGT1-3777M	Recombinant Mouse GNGT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GNGT1-3777M-B	Recombinant Mouse GNGT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Gngt1-1031M	Recombinant Mouse Gngt1 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Zebrafish	GNGT1-10332Z	Recombinant Zebrafish GNGT1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GNGT1 Related Articles

GNGT1 involved in several pathways and played different roles in them. We selected most pathways GNGT1 participated on our site, such as Ras signaling pathway, Chemokine signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNGT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ras signaling pathway	RRAS2;NGF;GNB1;RASAL3;RASGRP3;NRAS;RELA;FGF2;PRKACA
Chemokine signaling pathway	CXCL10;RHOA;KRAS;BCAR1;ROCK1;CCL19;CCL20;IKBKB;NCF1
PIK-Akt signaling pathway	FGFR1;SOS1;FGF11;KIT;GNB1;TCL1A;PRKCA;IL2RG;IFNAR1
Circadian entrainment	PLCB4;GNAI2;GRIA3;PLCB3;CAMK2B;GNGT2;PRKCB;PRKACB;PLCB2
Retrograde endocannabinoid signaling	GNG11;GNG13;GABRA6;PRKACA;GNAO1;GNB3;SLC17A8;PRKCA;SLC17A7
Glutamatergic synapse	GRM1;SLC1A7;GNG10;PLA2G4D;GNG7;GNB1;Adcy4;GNB4;GLS
Cholinergic synapse	GNG8;CAMK2D;NRAS;PLCB4;MAP2K1;GNG2;GNG5;CHAT;GNGT1
Serotonergic synapse	CYP2C70;GABRB3;ALOX15B;PRKCB;GNG7;HTR2A;HTR3C;GNG13;CYP2D26
GABAergic synapse	HAP1;GABRG1;GABARAPL1;GNB2;GNG12;SRC;PRKCG;GABRB2;GABARAP
Dopaminergic synapse	PLCB4;GNB3;KCNJ6;CALM1;PPP3CB;SCN1A;PPP1CC;PPP3CA;ATF6B
Phototransduction	GRK7;CALM;GUCA1B;RGS9;SAGA;CALML5;SLC24A1;CALM1B;CALM4
Alcoholism	HIST1H2BQ;H2AFX;SOS1;HIST2H3C;GM14476;H3F3C;GNG4;HAT1;GNAI3
Pathways in cancer	PRKCG;LAMA3;APPL1;PPARD;HDAC2;FZD5;FGF5;GSTP1;FGF4

GNGT1 has several biochemical functions, for example, GTPase activity, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNGT1 itself. We selected most functions GNGT1 had, and list some proteins which have the same functions with GNGT1. You can find most of the proteins on our site.

Function	Related Protein
GTPase activity	RABL2A;LSG1;GNA13A;ARL4C;EEFSEC;RABL5;RHEB;ARF3;RAB1A
protein binding	CDC20;BARHL2;AK3;OAS1B;DRD4;SNX7;MAGI1;ATP4B;HSPA8
signal transducer activity	TAAR14J;OLFR151;PLCD3;LGR4;PLCZ1;RGS9B;PLEKHG5;ADORA2AB;VMN1R40

GNGT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNGT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNGT1.

ZNF277

Lagman, D; Sundstrom, G; et al. Expansion of transducin subunit gene families in early vertebrate tetraploidizations. GENOMICS 100:203-211(2012).

Mulligan, T; Farber, SA; et al. Central and C-terminal domains of heterotrimeric G protein gamma subunits differentially influence the signaling necessary for primordial germ cell migration. CELLULAR SIGNALLING 23:1617-1624(2011).