grap
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  • Official Full Name
  • GRB2-related adaptor protein
  • Background
  • This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.
  • Synonyms
  • GRAP; GRB2-related adaptor protein; GRB2-related adapter protein; GRB2 related adaptor protein; Growth factor receptor bound protein 2 related adaptor protein; MGC64880; OTTHUMP00000065766; growth factor receptor-bound protein 2-related adaptor protein
Cat.#:GRAP-5032HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRAP Protein, GST-tagged
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Cat.#:GRAP-13515HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRAP, GST-tagged
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Cat.#:GRAP-7242MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GRAP Protein
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Cat.#:GRAP-1968RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GRAP Protein, His-tagged
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Cat.#:GRAP-4939CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GRAP
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Cat.#:GRAP-5758HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GRAP 293 Cell Lysate
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Involved Pathway

GRAP involved in several pathways and played different roles in them. We selected most pathways GRAP participated on our site, such as Kit Receptor Signaling Pathway, Signal Transduction, Signaling by SCF-KIT, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Kit Receptor Signaling Pathway
GRAPA; STAP1; GRAP; GRB7; SPRED2B; PTPRUB; DOK1B; DOK1; PTPRU; GRB10
Signal Transduction
RBP4; NRP2; METAP2B; WDR35; DHRS9; SOUL4; ZNRF3; ARHGAP33; HECW1B; OTUD7B
Signaling by SCF-KIT
PTPRU; GRAP; SH2B3; PTPRUB

Protein Function

GRAP has several biochemical functions, for example, SH3/SH2 adaptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRAP itself. We selected most functions GRAP had, and list some proteins which have the same functions with GRAP. You can find most of the proteins on our site.
Function
Related Protein
Function SH3/SH2 adaptor activity
Related Protein CD28; RUSC1; SLA2; CHN1; NCK2; SOCS2; LASP1; NCK1; SLA; GAB1
Function protein binding
Related Protein RAB3IL1; FAM60A; UPP2; XPA; CALR; GBA; CCDC88A; GJD3; C1orf189; MARVELD2

Interacting Protein

GRAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRAP here. Most of them are supplied by our site. Hope this information will be useful for your research of GRAP.
TRIM21; RBPMS; dapD; BCR; SHC1

GRAP Related Articles

Vazquez, DS; Agudelo, WA; et al. A helix-coil transition induced by the metal ion interaction with a grafted iron-binding site of the CyaY protein family. DALTON TRANSACTIONS 44:2370-2379(2015).
Su, HY; Chen, CC; et al. A Novel Fast Layout Encoding Method for Exact Multilayer Pattern Matching With Prufer Encoding. IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS 34:95-108(2015).