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GRHPR

Official Full Name

glyoxylate reductase/hydroxypyruvate reductase
Overview

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.
Synonyms

GRHPR; glyoxylate reductase/hydroxypyruvate reductase; GLXR; PH2; primary hyperoxaluria type 2; glycerate 2 dehydrogenase; GLYD; GRHPR_HUMAN; OTTHUMP00000021379; OTTHUMP00000021380; OTTHUMP00000046131; PH 2; glycerate-2-dehydrogenase;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Wheat Germ

Tag

GST
His
His|SUMO
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GRHPR-2491H	Recombinant Human GRHPR, His-tagged	E.coli	His		Inquiry
Human	GRHPR-28536TH	Recombinant Human GRHPR, His-tagged		His	328 amino acids	Inquiry
Human	GRHPR-13526H	Recombinant Human GRHPR, GST-tagged	E.coli	GST	100-328a.a.	$319 / 25ug
Human	GRHPR-28538TH	Recombinant Human GRHPR, His-tagged	E.coli	His	328 amino acids	Inquiry
Human	GRHPR-5749HCL	Recombinant Human GRHPR 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GRHPR-5329H	Recombinant Human GRHPR Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GRHPR-5619HF	Recombinant Full Length Human GRHPR Protein, GST-tagged	In Vitro Cell Free System	GST	328 amino acids	Inquiry
Human	GRHPR-2502H	Recombinant Human GRHPR Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Grhpr-1231M	Recombinant Mouse Grhpr Protein, His-SUMO-tagged	E.coli	His/SUMO		Inquiry
Mouse	Grhpr-3307M	Recombinant Mouse Grhpr Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GRHPR Related Articles

GRHPR involved in several pathways and played different roles in them. We selected most pathways GRHPR participated on our site, such as Glycine, serine and threonine metabolism, Pyruvate metabolism, Glyoxylate and dicarboxylate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRHPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycine, serine and threonine metabolism	PHGDH;GCSHB;SDSL;PSAT1;SHMT1;GCSH;DAO.1;MAOB;CBSB
Pyruvate metabolism	PDK2;HAGHL;LDHB;PDK4;ACYP2;PDPR;ME1;SLC16A1;PDP2
Glyoxylate and dicarboxylate metabolism	GCSH;PCCB;MDH2;GRHPR;GRHPRB;GCSHB;PGP;GLUL;ACO2
Metabolic pathways	RFK;NT5C2;ATP6AP1;NDUFA2;H6PD;NDUFV2;POLR2J3;CYP7A1;ALPPL2

GRHPR has several biochemical functions, for example, NAD binding, NADPH binding, carboxylic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRHPR itself. We selected most functions GRHPR had, and list some proteins which have the same functions with GRHPR. You can find most of the proteins on our site.

Function	Related Protein
NAD binding	IDH2;DLD;IDH3A;GLYR1;ME3;AOX3;GAPDH;CTBP2A;HIBADHB
NADPH binding	TP53I3;MTRR;CBR4;FASN;QDPR;DHFR;GRHPR;CRYZ;DECR1
carboxylic acid binding	AKR1C2;HIF1AN;GRHPR;AKR1C21;GOT1;HMGCL;PCK1
glycerate dehydrogenase activity
glyoxylate reductase (NADP) activity	GRHPR;GRHPRB;GRHPRA
hydroxypyruvate reductase activity	GRHPRB;GRHPR;GRHPRA
protein homodimerization activity	PEX7;CASQ2;DSCAML1;CADM1;LGALS1;NPM1;PAFAH1B1;SERPINF2;S100A6

GRHPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRHPR here. Most of them are supplied by our site. Hope this information will be useful for your research of GRHPR.

CDC7; LSM1; FOS; PTH2R; GLS2

Takayama, T; Takaoka, N; et al. Ethnic differences in GRHPR mutations in patients with primary hyperoxaluria type 2. CLINICAL GENETICS 86:342-348(2014).

Naderi, G; Latif, A; et al. Failure of isolated kidney transplantation in a pediatric patient with primary hyperoxaluria type 2. PEDIATRIC TRANSPLANTATION 18:E69-E73(2014).