grhpr
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  • Official Full Name
  • glyoxylate reductase/hydroxypyruvate reductase
  • Background
  • This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.
  • Synonyms
  • GRHPR; glyoxylate reductase/hydroxypyruvate reductase; GLXR; PH2; primary hyperoxaluria type 2; glycerate 2 dehydrogenase; GLYD; GRHPR_HUMAN; OTTHUMP00000021379; OTTHUMP00000021380; OTTHUMP00000046131; PH 2; glycerate-2-dehydrogenase
Cat.#:GRHPR-5329HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRHPR Protein, GST-tagged
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Cat.#:Grhpr-1231MTag:His|SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Grhpr Protein, His-SUMO-tagged
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Cat.#:GRHPR-13526HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRHPR, GST-tagged
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Cat.#:GRHPR-2491HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRHPR, His-tagged
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Cat.#:GRHPR-28536THTag:His
Source (Host):Species:Human
Product nameRecombinant Human GRHPR, His-tagged
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Cat.#:GRHPR-28538THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRHPR, His-tagged
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Cat.#:GRHPR-5749HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human GRHPR 293 Cell Lysate
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Involved Pathway

GRHPR involved in several pathways and played different roles in them. We selected most pathways GRHPR participated on our site, such as Glycine, serine and threonine metabolism, Pyruvate metabolism, Glyoxylate and dicarboxylate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRHPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycine, serine and threonine metabolism
CBS; PSAT1; MAOB; BHMT; SDS; ALAS1; CBSA; CHDH; DAO; GCSH
Pyruvate metabolism
ALDH7A1; PC; ACSS1; DLAT; GRHPRB; PDHA1A; PDK2; DLDH; PCK2; ME2
Glyoxylate and dicarboxylate metabolism
PCCA; ACO1; MDH1AA; PGP; MCEE; GLYCTK; GCSH; GRHPR; CAT; PCCB
Metabolic pathways
UOX; ACLY; Nat3; EXTL2; PNPLA2; MAN1A1; KHK; POLR2J3; ATP6V0A2; NDUFA13

Protein Function

GRHPR has several biochemical functions, for example, NAD binding, NADPH binding, carboxylic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRHPR itself. We selected most functions GRHPR had, and list some proteins which have the same functions with GRHPR. You can find most of the proteins on our site.
Function
Related Protein
Function NAD binding
Related Protein UGDH; PHGDH; HSD3B5; GAPDH; HSD11B2; HIBADHB; PARP1; HADHA; CTBP2A; DLD
Function NADPH binding
Related Protein GRHPR; TP53I3; MTRR; HMGCR; CBR4; FASN; DHFR; QDPR; CRYZ; DECR1
Function carboxylic acid binding
Related Protein AKR1C2; GOT1; HIF1AN; GRHPR; HMGCL; PCK1; AKR1C21
Function glycerate dehydrogenase activity
Related Protein GRHPR
Function glyoxylate reductase (NADP) activity
Related Protein GRHPRA; GRHPR; GRHPRB
Function hydroxypyruvate reductase activity
Related Protein GRHPRB; GRHPRA; GRHPR
Function protein homodimerization activity
Related Protein S100A10; SLC16A1; APOA2; GRHPR; MUC13; BST2; AXIN1; TP53I3; XBP1; C1QB

Interacting Protein

GRHPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRHPR here. Most of them are supplied by our site. Hope this information will be useful for your research of GRHPR.
CDC7; LSM1; FOS; PTH2R; GLS2

GRHPR Related Articles

Takayama, T; Takaoka, N; et al. Ethnic differences in GRHPR mutations in patients with primary hyperoxaluria type 2. CLINICAL GENETICS 86:342-348(2014).
Naderi, G; Latif, A; et al. Failure of isolated kidney transplantation in a pediatric patient with primary hyperoxaluria type 2. PEDIATRIC TRANSPLANTATION 18:E69-E73(2014).