• Official Full Name
  • G1 to S phase transition 2
  • Background
  • This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.
  • Synonyms
  • GSPT2; G1 to S phase transition 2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B; eRF3b; FLJ10441; eukaryotic peptide chain release factor subunit 3b; GST2
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GSPT2 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GSPT2 Protein
Source (Host):Species:Human
Product nameRecombinant Human GSPT2 293 Cell Lysate

Involved Pathway

GSPT2 involved in several pathways and played different roles in them. We selected most pathways GSPT2 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSPT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mRNA surveillance pathway

Protein Function

GSPT2 has several biochemical functions, for example, GTP binding, GTPase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSPT2 itself. We selected most functions GSPT2 had, and list some proteins which have the same functions with GSPT2. You can find most of the proteins on our site.
Related Protein
Function GTP binding
Related Protein RAB33B; GUCY1B3; DNM2A; HRASB; RAB32A; RAB3B; MXB; DNM1A; TUBG2; CDC42L2
Function GTPase activity
Related Protein GFM1; RAB22A; TUBA3D; SAR1B; RAB1B; TUBA4L; RAB3D; ATL1; TUBA8; TUBB4B
Function poly(A) RNA binding
Related Protein HNRNPAB; NHP2; CIRBP; RBM10; MECP2; CCT6A; FBL; SRP54; TRIP6; TAF15
Function protein binding
Related Protein EPHB6; ING1; NACC2; KPNA6; TFG; SNAP23; SOCS3; MGP; ZNF593; CCDC116
Function translation release factor activity
Related Protein GSPT2; GSPT1L; MTRF1; ETF1

Interacting Protein

GSPT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSPT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSPT2.
PABPC1; UPF1; ETF1; Pabpc1; Etf1; SMG1

GSPT2 Related Articles

Li, M; Wang, J; et al. eRF3b, a Biomarker for Hepatocellular Carcinoma, Influences Cell Cycle and Phosphoralation Status of 4E-BP1. PLOS ONE 9:-(2014).
Xiao, RL; Gao, Y; et al. Polypeptide chain release factor eRF3 is a novel molecular partner of survivin. CELL BIOLOGY INTERNATIONAL 37:359-369(2013).