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GSPT2

  • Official Full Name

    G1 to S phase transition 2

  • Overview

    This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.
  • Synonyms

    GSPT2; G1 to S phase transition 2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B; eRF3b; FLJ10441; eukaryotic peptide chain release factor subunit 3b; GST2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GSPT2-4403H Recombinant Human GSPT2 Protein, GST-tagged Wheat Germ GST
Human GSPT2-5721HCL Recombinant Human GSPT2 293 Cell Lysate HEK293 N/A
Human GSPT2-3331HF Recombinant Full Length Human GSPT2 Protein, GST-tagged In Vitro Cell Free System GST 628 amino acids
Mouse GSPT2-7321M Recombinant Mouse GSPT2 Protein Mammalian Cell His
Mouse GSPT2-3963M-B Recombinant Mouse GSPT2 Protein Pre-coupled Magnetic Beads HEK293
Mouse GSPT2-3963M Recombinant Mouse GSPT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GSPT2 Related Articles

GSPT2 involved in several pathways and played different roles in them. We selected most pathways GSPT2 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSPT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
mRNA surveillance pathwayWIBG;NXF2;PABPC1;PABPC1L2A;PPP1CB;PAPOLB;PPP2R5E;CSTF2T;PABPC1A

GSPT2 has several biochemical functions, for example, GTP binding, GTPase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSPT2 itself. We selected most functions GSPT2 had, and list some proteins which have the same functions with GSPT2. You can find most of the proteins on our site.

Function Related Protein
GTP bindingTUBAL3;NOA1;MFN1B;ACSM1;GLUD2;RABL2A;TUBA7L;RAB38;RAB11BA
GTPase activityDIRAS3;ARL3;RALB;RAB20;RAB1;RAB12;ARL1;SEPT4;GNA13B
poly(A) RNA bindingMRPL3;RPL29;PES1;OTUD4;ZMAT3;SRSF2;SLIRP;ZNF622;AKAP8L
protein bindingSMYD1;SNCG;TERF1;EIF4G2;WRAP53;PLSCR3;GJB6;INHA;PPIL3
translation release factor activityETF1;MTRF1;GSPT2;GSPT1L

GSPT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSPT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSPT2.

PABPC1; UPF1; ETF1; Pabpc1; Etf1; SMG1

Li, M; Wang, J; et al. eRF3b, a Biomarker for Hepatocellular Carcinoma, Influences Cell Cycle and Phosphoralation Status of 4E-BP1. PLOS ONE 9:-(2014).
Xiao, RL; Gao, Y; et al. Polypeptide chain release factor eRF3 is a novel molecular partner of survivin. CELL BIOLOGY INTERNATIONAL 37:359-369(2013).
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