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GSTM3

  • Official Full Name

    glutathione S-transferase mu 3 (brain)

  • Overview

    Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.
  • Synonyms

    GSTM3; glutathione S-transferase mu 3 (brain); glutathione S transferase M3 (brain); glutathione S-transferase Mu 3; GST5; brain GST; brain type mu glutathione S transferase; glutathione S alkyltransferase M3; glutathione S aryltransferase M3; glutathione S transferase M3; Glutathione S transferase Mu 3; glutathione S transferase, Mu 3; GST class mu 3; GST class-mu 3; GSTB; GSTM3-3; GSTM3_HUMAN; GTM3; hGSTM3-3; MGC3310; MGC3704; S (hydroxyalkyl)glutathione lyase M3; glutathione S-transferase, Mu-3; glutathione S-aryltransferase M3; glutathione S-alkyltransferase M3; glutathione S-aralkyltransferase M3; S-(hydroxyalkyl)glutathione lyase M3; glutathione S-transferase M3 (brain); brain type mu-glutathione S-transferase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GSTM3-664H Recombinant Human GSTM3 protein, His & T7-tagged E.coli His/T7 Val8~Pro223 (Accession # P21266)
Human GSTM3-4419H Recombinant Human GSTM3 Protein, GST-tagged Wheat Germ GST
Human GSTM3-759HCL Recombinant Human GSTM3 cell lysate N/A
Human GSTM3-3363HF Recombinant Full Length Human GSTM3 Protein, GST-tagged In Vitro Cell Free System GST 65 amino acids
Human GSTM3-301608H Recombinant Human GSTM3 protein, GST-tagged E.coli GST Met1-Cys225
Human GSTM3-301608H Recombinant Human GSTM3 protein, GST-tagged E.coli GST Met1-Cys225
Human GSTM3-12H Active Recombinant Human GSTM3 Protein (1-225aa), N-His tagged E.coli N-His 1-225aa
Human GSTM3-3402H Recombinant Human GSTM3 protein, His-tagged E.coli His 1-225 aa
Human GSTM3-2555H Recombinant Human GSTM3 Protein (Val8-Pro223), N-His tagged E.coli N-His Val8-Pro223
Mouse GSTM3-7332M Recombinant Mouse GSTM3 Protein Mammalian Cell His
Mouse GSTM3-3974M Recombinant Mouse GSTM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GSTM3-3974M-B Recombinant Mouse GSTM3 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GSTM3-576C Recombinant Cynomolgus GSTM3 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GSTM3-322C-B Recombinant Cynomolgus Monkey GSTM3 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GSTM3-322C Recombinant Cynomolgus Monkey GSTM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GSTM3-1993R Recombinant Rhesus monkey GSTM3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GSTM3-1814R-B Recombinant Rhesus Macaque GSTM3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GSTM3-1814R Recombinant Rhesus Macaque GSTM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish GSTM3-7542Z Recombinant Zebrafish GSTM3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GSTM3 Related Articles

GSTM3 involved in several pathways and played different roles in them. We selected most pathways GSTM3 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glutathione metabolismGGCTA;GSTM5;GPX4;G6PD;GSTM2;GSS;GGT7;SMS;TXNDC12
Metabolism of xenobiotics by cytochrome PHSD11B1;GSTO1;UGT1A4;UGT1A3;UGT2A3;UGT1A9;EPHX1;GSTAL;UGT1A6
Drug metabolism - cytochrome PUGT2A3;GSTM6;FMO3;UGT1A7C;AOX2P;AOX3;UGT2A1;FMO2;GSTT1
Chemical carcinogenesisNat3;CYP2C55;MGST1;ARNT;GSTA4;CYP3A43;ALDH1A3;CYP3A7;CBR1

GSTM3 has several biochemical functions, for example, enzyme binding, glutathione binding, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTM3 itself. We selected most functions GSTM3 had, and list some proteins which have the same functions with GSTM3. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingHNRNPUL1;TSPAN15;CALU;ATP2A2;RPA3;Txn1;LAMB1;AXIN1;PUS7
glutathione bindingGSTM2;GSTM4;LTC4S;GSS;GSTP2;PTGES2;PTGESL;GPX1;GSTM3
glutathione transferase activityGSTAL;GSTA1;MGST2;EEF1E1;GDAP1L1;HPGDS;GSTT1B;GSTZ1;GRX2
identical protein bindingCEP170L;JMJD6;EIF2AK3;TRIM5;ESR1;OMG;STAC3;TRIP10;HCFC1
protein homodimerization activityKCNN2;IRAK3;TCF4;TBX18;SP100;C6orf108;MAP3K9;MYOM1;NACC2

GSTM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTM3.

GH1; TFE3; MPG; HLA-C; PAK2; ATG5; TRAF6; SH3GL2; GRB2; RBL2

Tatemichi, M; Iwasaki, M; et al. Association between polymorphisms in glutathione S-transferase Mu3 and IgG titer levels in serum against Helicobacter pylori. JOURNAL OF HUMAN GENETICS 54:557-563(2009).
Nishimura, J; Dewa, Y; et al. Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats. ARCHIVES OF TOXICOLOGY 82:641-654(2008).
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