gstm3
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  • Official Full Name
  • glutathione S-transferase mu 3 (brain)
  • Background
  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • GSTM3; glutathione S-transferase mu 3 (brain); glutathione S transferase M3 (brain); glutathione S-transferase Mu 3; GST5; brain GST; brain type mu glutathione S transferase; glutathione S alkyltransferase M3; glutathione S aryltransferase M3; glutathione S transferase M3; Glutathione S transferase Mu 3; glutathione S transferase, Mu 3; GST class mu 3; GST class-mu 3; GSTB; GSTM3-3; GSTM3_HUMAN; GTM3; hGSTM3-3; MGC3310; MGC3704; S (hydroxyalkyl)glutathione lyase M3; glutathione S-transferase, Mu-3; glutathione S-aryltransferase M3; glutathione S-alkyltransferase M3; glutathione S-aralkyltransferase M3; S-(hydroxyalkyl)glutathione lyase M3; glutathione S-transferase M3 (brain); brain type mu-glutathione S-transferase
Cat.#:GSTM3-4419HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GSTM3 Protein, GST-tagged
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Cat.#:GSTM3-664HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSTM3 protein, His & T7-tagged
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Cat.#:GSTM3-7332MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GSTM3 Protein
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Cat.#:GSTM3-576CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GSTM3 Protein, His-tagged
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Cat.#:GSTM3-1993RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GSTM3 Protein, His-tagged
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Cat.#:GSTM3-7542ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GSTM3
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Cat.#:GSTM3-759HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GSTM3 cell lysate
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Involved Pathway

GSTM3 involved in several pathways and played different roles in them. We selected most pathways GSTM3 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glutathione metabolism
OPLAH; ANPEPB; GPX1; GGT5A; GPX2; GPX4; GSTM6; GSS; GPX5; RRM2B
Metabolism of xenobiotics by cytochrome P
CYP1A; MGST3; GSTO1; AKR7A5; GSTA; CBR1; AKR7A2; UGT2A2; AKR7A3; MGST1
Drug metabolism - cytochrome P
GSTM1; GSTT1; GSTA; UGT1A6B; AOX1; GSTP2; GSTM; MGST2; GSTT2B; GSTA3
Chemical carcinogenesis
GSTT2; CYP1A1; UGT1A3; CYP2C54; CYP2C37; UGT1A6A; CYP3A25; ADH4; GSTK1; UGT1A1

Protein Function

GSTM3 has several biochemical functions, for example, enzyme binding, glutathione binding, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTM3 itself. We selected most functions GSTM3 had, and list some proteins which have the same functions with GSTM3. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein LDB1; TULP3; MAP2K7; JUND; MDM4; CYP3A4; WWOX; FOXO4; MST1R; SRC
Function glutathione binding
Related Protein MGST1; GSTM4; GSS; LANCL1; GSTM7; PTGES2; GSTP2; GSTM2; GPX1; GSTM3
Function glutathione transferase activity
Related Protein GSTT4; GSTK1; GSTM; GSTM1; GSTA3; GSTA5; MGST1; GSTP1; GSTM7; GSTAL
Function identical protein binding
Related Protein GOT2A; DYNLT1; PRMT8; SELK; GYPA; GPR50; ZNF703; CCDC91; BNIP2; S100A1
Function protein homodimerization activity
Related Protein MYPOP; GIPC1; SMAD4; LMLN; XPNPEP1; BAK1; FZD9; PRLR; IDH1; MTERFD3

Interacting Protein

GSTM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTM3.
GH1; TFE3; MPG; HLA-C; PAK2; ATG5; TRAF6; SH3GL2; GRB2; RBL2

GSTM3 Related Articles

Tatemichi, M; Iwasaki, M; et al. Association between polymorphisms in glutathione S-transferase Mu3 and IgG titer levels in serum against Helicobacter pylori. JOURNAL OF HUMAN GENETICS 54:557-563(2009).
Nishimura, J; Dewa, Y; et al. Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats. ARCHIVES OF TOXICOLOGY 82:641-654(2008).