GSTM5

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GSTM5

Official Full Name glutathione S-transferase mu 5
Background Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds.
Synonyms GSTM5; glutathione S-transferase mu 5; glutathione S transferase M5; Glutathione S alkyltransferase M5; Glutathione S aralkyltransferase M5; Glutathione S aryltransferase M5; Glutathione S transferase Mu 5; GST class mu 5; GST class-mu 5; GSTM 5; GSTM5 5; GSTM5-5; GSTM5_HUMAN; GTM 5; GTM5; OTTHUMP00000013359; OTTHUMP00000013361; S (hydroxyalkyl)glutathione lyase M5; glutathione S-transferase M5; glutathione S-aryltransferase M5; glutathione S-alkyltransferase M5; glutathione S-aralkyltransferase M5; S-(hydroxyalkyl)glutathione lyase M5
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GSTM5-1489H Recombinant Human GSTM5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human GSTM5-13578H Recombinant Human GSTM5, GST-tagged E.coli GST
    Human GSTM5-2460H Recombinant Human GSTM5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GSTM5-2481H Recombinant Human Glutathione S-Transferase Mu 5, His-tagged E.coli His
    Human GSTM5-25H Recombinant Human GSTM5 protein, His-tagged E.coli His
    Human GSTM5-27772TH Recombinant Human GSTM5, GST-tagged Wheat Germ GST
    Human GSTM5-300H Recombinant Human GSTM5, His-tagged E.coli His
    Human GSTM5-760HCL Recombinant Human GSTM5 cell lysate N/A
    Mouse GSTM5-7334M Recombinant Mouse GSTM5 Protein Mammalian Cell His
    Rat GSTM5-2733R Recombinant Rat GSTM5 Protein Mammalian Cell His
    Cynomolgus Monkey GSTM5-578C Recombinant Cynomolgus GSTM5 Protein, His-tagged Mammalian Cell His

    GSTM5 involved in several pathways and played different roles in them. We selected most pathways GSTM5 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glutathione metabolism RRM1; GGT1; GSTM6; GSTAL; PGD; GPX4; GSTT1; GSTA1; GSTA5; GSTM4
    Metabolism of xenobiotics by cytochrome P ALDH3A1; CBR2; DHDH; MGST1.2; UGT1A6A; GSTA4; GSTA5; EPHX1; GSTM1; GSTA3
    Drug metabolism - cytochrome P AOX3; MGST1.1; GSTM1; ALDH1A3; MGST3; FMO3; UGT1A6; FMO6P; UGT1A7; GSTA1
    Chemical carcinogenesis SULT1A3; ADH1; ALDH3B1; GSTM5; ADH2-2; UGT1A3; UGT2A1; GSTM7; GSTA3; AKR1C2

    GSTM5 has several biochemical functions, for example, glutathione transferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTM5 itself. We selected most functions GSTM5 had, and list some proteins which have the same functions with GSTM5. You can find most of the proteins on our site.

    Function Related Protein
    glutathione transferase activity GSTAL; GSTM3; GSTK1; GSTA3; GSTA5; GSTA4; MGST2; HPGDS; LTC4S; GSTO1
    protein binding MAP3K7; C17orf59; NUS1; FAH; TNFRSF11A; SLA2; HMGN4; NAMPT; VPS72; MAP3K14

    GSTM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTM5.

    GSTM3; AMOTL2; PPP1CC

    Yen, YK; Jiang, YW; et al. Western Blotting by Thin-Film Direct Coating. ANALYTICAL CHEMISTRY 86:5164-5170(2014).
    Iannacone, MR; Gheit, T; et al. Case-Control Study of Cutaneous Human Papillomaviruses in Squamous Cell Carcinoma of the Skin. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 21:1303-1313(2012).

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