GTF2H2 Protein, general transcription factor IIH, polypeptide 2, 44kDa

GTF2H2

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GTF2H2

Official Full Name general transcription factor IIH, polypeptide 2, 44kDa
Background This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.
Synonyms GTF2H2; general transcription factor IIH, polypeptide 2, 44kDa; general transcription factor IIH, polypeptide 2 (44kD subunit); general transcription factor IIH subunit 2; BTF2; BTF2P44; T BTF2P44; TFIIH; MGC102806; Basic transcription factor 2 44 kDa subunit; General transcription factor IIH; BTF2 p44; OTTHUMP00000223559; OTTHUMP00000223561; OTTHUMP00000224504; general transcription factor IIH polypeptide 2; TFIIH basal transcription factor complex p44 subunit; ge; T-BTF2P44
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GTF2H2-13596H Recombinant Human GTF2H2, His-tagged E.coli His
    Human GTF2H2-2673H Recombinant Human GTF2H2, His-tagged E.coli His
    Human GTF2H2-4449H Recombinant Human GTF2H2 Protein, GST-tagged Wheat Germ GST
    Human GTF2H2-5697HCL Recombinant Human GTF2H2 293 Cell Lysate HEK293 N/A
    Rat GTF2H2-2743R Recombinant Rat GTF2H2 Protein Mammalian Cell His
    Rhesus Macaque GTF2H2-2007R Recombinant Rhesus monkey GTF2H2 Protein, His-tagged Mammalian Cell His
    Zebrafish GTF2H2-11563Z Recombinant Zebrafish GTF2H2 Mammalian Cell His

    GTF2H2 involved in several pathways and played different roles in them. We selected most pathways GTF2H2 participated on our site, such as Basal transcription factors, Nucleotide excision repair, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GTF2H2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Basal transcription factors TBP; CDK7; GTF2H2C; GTF2IRD1; GTF2H4; TAF11; GTF2F2; TAF12; TAF1L; TAF10
    Nucleotide excision repair INO80; GTF2H2C_2; GPS1; GTF2H2C; RPA1; ERCC1; MCRS1; RBX1; COPS3; KIAA1530
    Viral carcinogenesis PRKACB; CREB3L2; HLA-B; VDAC3; HIST1H2BB; IRF7; UBE3A; HDAC7; KAT2A; BAX

    GTF2H2 has several biochemical functions, for example, contributes_to DNA-dependent ATPase activity, contributes_to RNA polymerase II carboxy-terminal domain kinase activity, nucleic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GTF2H2 itself. We selected most functions GTF2H2 had, and list some proteins which have the same functions with GTF2H2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to DNA-dependent ATPase activity MNAT1; GTF2H2; ERCC3; RBBP4; GTF2H3; GTF2H4; ERCC2; GTF2H1; BPTF
    contributes_to RNA polymerase II carboxy-terminal domain kinase activity GTF2H2; GTF2H4; GTF2H3; GTF2H1; ERCC2; MNAT1; ERCC3
    nucleic acid binding SRSF6A; CNOT4B; ZFP14; MTHFSD; RBPMS2B; SP8B; ZFP260; ZFP346; TDRKH; USP6
    protein N-terminus binding PIAS3; RPS21; ERCC5; MAU2; HAX1; SYNGR3; PDLIM5; RASSF1; DCTN4; CSNK2A1
    protein binding NOS2; CUL3; PRDM16; PREP; GIMAP5; TNFRSF11A; PLK1S1; ROS1; SRSF3; MATN4
    contributes_to protein kinase activity GTF2H4; ERCC2; GTF2H1; GTF2H3; ERCC3; GTF2H2
    transcription factor activity, sequence-specific DNA binding SMAD6A; RORAA; HOXB7A; ZNF79; GATA1A; ZNF583; FOXE1; SALL1A; HOXB5A; GABPA
    translation factor activity, RNA binding EIF4A1; EIF5; EEF2K; GTF2H2; EIF4H; CPEB4; CPEB1; CPEB3; EIF4G2; GTF2H3
    zinc ion binding UNK; MMP3; MMP1A; THRB; ADAM15; TRIM17; ZDHHC11; MT1X; MNAT1; ZSWIM2

    GTF2H2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTF2H2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GTF2H2.

    ERCC8; GTF2H1; phoA; CDK7; GTF2H5

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