H2AFY2 Protein, H2A histone family, member Y2


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Official Full Name H2A histone family, member Y2
Background Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Synonyms H2AFY2; H2A histone family, member Y2; macroH2A2; core histone macro-H2A.2; mH2A2; histone macroH2A2; core histone macroH2A2.2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human H2AFY2-13648H Recombinant Human H2AFY2, His-tagged E.coli His
    Human H2AFY2-30081TH Recombinant Human H2AFY2, His-tagged E.coli His
    Human H2AFY2-4539H Recombinant Human H2AFY2 Protein, GST-tagged Wheat Germ GST
    Human H2AFY2-5656HCL Recombinant Human H2AFY2 293 Cell Lysate HEK293 N/A
    Mouse H2AFY2-7431M Recombinant Mouse H2AFY2 Protein Mammalian Cell His
    Rhesus Macaque H2AFY2-2029R Recombinant Rhesus monkey H2AFY2 Protein, His-tagged Mammalian Cell His
    Chicken H2AFY2-4762C Recombinant Chicken H2AFY2 Mammalian Cell His
    Zebrafish H2AFY2-3124Z Recombinant Zebrafish H2AFY2 Mammalian Cell His

    H2AFY2 involved in several pathways and played different roles in them. We selected most pathways H2AFY2 participated on our site, such as Alcoholism, Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with H2AFY2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Systemic lupus erythematosus HIST1H2BI; HIST1H3A; C1QB; HLA-DRB5; HIST1H2AN; HIST1H2AG; HIST1H3G; HIST1H4H; H3F3A; HIST1H2AC

    H2AFY2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin DNA binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by H2AFY2 itself. We selected most functions H2AFY2 had, and list some proteins which have the same functions with H2AFY2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding GATA6; ATF4B1; EOMES; MSX1; CREBBP; MEF2A; NHLH2; TRPS1; SOX13; ONECUT3
    chromatin DNA binding XBP1; HIST1H1D; GATA1; PER1; GRHL1; PRDM14; MYOG; RUVBL2; VAX1; VAX2
    protein heterodimerization activity TAL1; H2AFVB; CAV1; SAE1; ODZ4; SOS1; CENPA; TCF3B; CAV2; Bcl2a1b
    transcription regulatory region DNA binding HIVEP2A; TBL1X; TCF7; TBX16; TFAP2A; TAF7; SMARCA2; GATA3; SMAD7; SNCA

    H2AFY2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H2AFY2 here. Most of them are supplied by our site. Hope this information will be useful for your research of H2AFY2.

    CDC37; WWP1; PYHIN1

    Tanasijevic, B; Rasmussen, TP; et al. X Chromosome Inactivation and Differentiation Occur Readily in ES Cells Doubly-Deficient for MacroH2A1 and MacroH2A2. PLOS ONE 6:-(2011).
    Geigl, JB; Langer, S; et al. Analysis of gene expression patterns and chromosomal changes associated with aging. CANCER RESEARCH 64:8550-8557(2004).

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