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H2AFY2

  • Official Full Name

    H2A histone family, member Y2

  • Overview

    Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
  • Synonyms

    H2AFY2; H2A histone family, member Y2; macroH2A2; core histone macro-H2A.2; mH2A2; histone macroH2A2; core histone macroH2A2.2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human H2AFY2-4539H Recombinant Human H2AFY2 Protein, GST-tagged Wheat Germ GST
Human H2AFY2-30081TH Recombinant Human H2AFY2, His-tagged E.coli His
Human H2AFY2-13648H Recombinant Human H2AFY2, His-tagged E.coli His 1-372a.a.
Human H2AFY2-5656HCL Recombinant Human H2AFY2 293 Cell Lysate HEK293 N/A
Human H2AFY2-3405HF Recombinant Full Length Human H2AFY2 Protein, GST-tagged In Vitro Cell Free System GST 372 amino acids
Mouse H2AFY2-7431M Recombinant Mouse H2AFY2 Protein Mammalian Cell His
Mouse H2AFY2-4043M-B Recombinant Mouse H2AFY2 Protein Pre-coupled Magnetic Beads HEK293
Mouse H2AFY2-4043M Recombinant Mouse H2AFY2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque H2AFY2-2029R Recombinant Rhesus monkey H2AFY2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque H2AFY2-1850R Recombinant Rhesus Macaque H2AFY2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque H2AFY2-1850R-B Recombinant Rhesus Macaque H2AFY2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish H2AFY2-3124Z Recombinant Zebrafish H2AFY2 Mammalian Cell His
Chicken H2AFY2-4762C Recombinant Chicken H2AFY2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • H2AFY2 Related Articles

H2AFY2 involved in several pathways and played different roles in them. We selected most pathways H2AFY2 participated on our site, such as Alcoholism, Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with H2AFY2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AlcoholismCAMKK1;HIST1H2AM;H2AFY;HDAC8;H2BFWT;PKIA;GNG5;SHC1;MAPK3
Systemic lupus erythematosusC8G;HIST1H2AE;HLA-DRB5;FCGR4;H2AFJ;HIST3H2BB-PS;HIST1H2BM;CD40LG;HIST1H2BF

H2AFY2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin DNA binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by H2AFY2 itself. We selected most functions H2AFY2 had, and list some proteins which have the same functions with H2AFY2. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II regulatory region sequence-specific DNA bindingZFY2;PHOX2A;GATA2;CUX1;ZNF480;ZNF549;RXRG;BHLHA15;RELB
chromatin DNA bindingCLOCK;GRHL3;SRF;H2AFY;PER1;WBP2;HIST1H1A;VAX2;MYOG
protein heterodimerization activityPANX2;NR4A2;SMAD3;HIST1H3A;ATF2;TCF4;HGF;HIST1H2AL;PDSS1
transcription regulatory region DNA bindingTAF2;HIVEP2A;MEF2C;HNF4A;SP1;CTCFL;MTERF3;FOS;ZFP746

H2AFY2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H2AFY2 here. Most of them are supplied by our site. Hope this information will be useful for your research of H2AFY2.

CDC37; WWP1; PYHIN1

Tanasijevic, B; Rasmussen, TP; et al. X Chromosome Inactivation and Differentiation Occur Readily in ES Cells Doubly-Deficient for MacroH2A1 and MacroH2A2. PLOS ONE 6:-(2011).
Geigl, JB; Langer, S; et al. Analysis of gene expression patterns and chromosomal changes associated with aging. CANCER RESEARCH 64:8550-8557(2004).
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