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HBS1L

  • Official Full Name

    HBS1-like (S. cerevisiae)

  • Overview

    This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
  • Synonyms

    HBS1L; HBS1-like (S. cerevisiae); HBS1 (S. cerevisiae) like; HBS1-like protein; DKFZp434g247; EF 1a; ERFS; HBS1; HSPC276; KIAA1038; ERF3 similar protein; HBS1 like protein; Hsp70 subfamily B suppressor 1 like protein; ERF3-similar protein; Hsp70 subfamily B suppressor 1-like protein; EF-1a;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HBS1L-4609H Recombinant Human HBS1L Protein, GST-tagged Wheat Germ GST
Human HBS1L-5617HCL Recombinant Human HBS1L 293 Cell Lysate HEK293 N/A
Human HBS1L-3500HF Recombinant Full Length Human HBS1L Protein, GST-tagged In Vitro Cell Free System GST 684 amino acids
Rat HBS1L-2802R Recombinant Rat HBS1L Protein Mammalian Cell His
Rat HBS1L-2457R-B Recombinant Rat HBS1L Protein Pre-coupled Magnetic Beads HEK293
Rat HBS1L-2457R Recombinant Rat HBS1L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HBS1L-10075Z Recombinant Zebrafish HBS1L Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HBS1L Related Articles

HBS1L involved in several pathways and played different roles in them. We selected most pathways HBS1L participated on our site, such as Legionellosis, mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HBS1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LegionellosisSEC22B;BNIP3;EEF1G;BCL2L13;CYCS;CXCL3;HSPD1;HSPA1L;TLR2
mRNA surveillance pathwayPPP2R5A;PPP2R5B;SMG5;PPP2R5EB;PPP2R5C;PAPOLG;pab1;PABPN1;PABPC1L

HBS1L has several biochemical functions, for example, GTP binding, GTPase activity, translation elongation factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HBS1L itself. We selected most functions HBS1L had, and list some proteins which have the same functions with HBS1L. You can find most of the proteins on our site.

Function Related Protein
GTP bindingRAB14L;IFT22;TUFM;GNAT3;MXB;DIRAS1A;EEF1A2;RP2;RHOGD
GTPase activityDDX3X;RAB18B;TUBG1;RAB19;TUBA7L;GNA15.1;GNAZ;GNAI3;TUBA3E
translation elongation factor activityTUFM;EEF1E1;EIF5A;EEF1B2;EEF1G;EEF1D;EEF1DB;GFM1;HBS1L

HBS1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HBS1L here. Most of them are supplied by our site. Hope this information will be useful for your research of HBS1L.

UBA1; UBE2N; SRPK2; UBE2V1; Map3k1; SRPK1; UBE2G2; q8clf6_yerpe; SNW1; ULK2; DIS3L; CDC5L

Bitoungui, VJN; Ngogang, J; et al. Polymorphism at BCL11A compared to HBS1L-MYB loci explains less of the variance in HbF in patients with sickle cell disease in Cameroon. BLOOD CELLS MOLECULES AND DISEASES 54:268-269(2015).
Mtatiro, SN; Mgaya, J; et al. Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer. BMC MEDICAL GENETICS 16:-(2015).
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