hbs1l
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  • Official Full Name
  • HBS1-like (S. cerevisiae)
  • Background
  • This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
  • Synonyms
  • HBS1L; HBS1-like (S. cerevisiae); HBS1 (S. cerevisiae) like; HBS1-like protein; DKFZp434g247; EF 1a; ERFS; HBS1; HSPC276; KIAA1038; ERF3 similar protein; HBS1 like protein; Hsp70 subfamily B suppressor 1 like protein; ERF3-similar protein; Hsp70 subfamily B suppressor 1-like protein; EF-1a
Cat.#:HBS1L-4609HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HBS1L Protein, GST-tagged
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Cat.#:HBS1L-2802RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HBS1L Protein
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Cat.#:HBS1L-10075ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HBS1L
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Cat.#:HBS1L-5617HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HBS1L 293 Cell Lysate
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Involved Pathway

HBS1L involved in several pathways and played different roles in them. We selected most pathways HBS1L participated on our site, such as Legionellosis, mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HBS1L were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Legionellosis
SEC22B; Itgam&Itgb2; HSPA8; CR1; EEF1G; EEF1A1; NFKB2; APAF1; HSPD1; CASP9
mRNA surveillance pathway
PPP2R5EA; SYMPK; CPSF6; PAPOLB; PPP2R5D; PPP1CAB; ETF1; PABPC4; BCL2L2-PABPN1; CPSF7

Protein Function

HBS1L has several biochemical functions, for example, GTP binding, GTPase activity, translation elongation factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HBS1L itself. We selected most functions HBS1L had, and list some proteins which have the same functions with HBS1L. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein NUDT2; ARL2; RAB7B; ADSS; RASD2; GNL1; EEF1A2; RAB1BB; LRRK1; LRRK2
Function GTPase activity
Related Protein CDC42; RAB1BB; RAP2A; RHOB; RAN; GNA13B; RAB18B; RASEF; IRGE4; RABL2
Function translation elongation factor activity
Related Protein EEF1DB; EEF1B2; ABTB1; EIF5A; EEF1G; TUFM; EEF2; EEF1A1; HBS1L; EEF1A1L1

Interacting Protein

HBS1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HBS1L here. Most of them are supplied by our site. Hope this information will be useful for your research of HBS1L.
UBA1; UBE2N; SRPK2; UBE2V1; Map3k1; SRPK1; UBE2G2; q8clf6_yerpe; SNW1; ULK2; DIS3L; CDC5L

HBS1L Related Articles

Bitoungui, VJN; Ngogang, J; et al. Polymorphism at BCL11A compared to HBS1L-MYB loci explains less of the variance in HbF in patients with sickle cell disease in Cameroon. BLOOD CELLS MOLECULES AND DISEASES 54:268-269(2015).
Mtatiro, SN; Mgaya, J; et al. Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer. BMC MEDICAL GENETICS 16:-(2015).