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HEY1

  • Official Full Name

    hairy/enhancer-of-split related with YRPW motif 1

  • Overview

    This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.
  • Synonyms

    HEY1; hairy/enhancer-of-split related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1; BHLHb31; CHF 2; CHF2; HERP2; HESR 1; HESR1; HRT 1; Basic helix loop helix protein OAF1; Cardiovascular helix loop helix factor 2; Cardiovascular helix loop-helix factor 2; Cardiovascular helix-loop-helix factor 2; CHF-2; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split related protein 1; Hairy and enhancer of split-related protein 1; Hairy enhancer-of-split related with YRPW motif protein 1; Hairy related transcription factor 1; Hairy-related transcription factor 1; Hairy/enhancer of split related with YRPW motif 1; HERP 2; HES related repressor protein 1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-1; HEY 1; HEY1_HUMAN; hHRT1; HRT-1; HRT1; MGC1274; OAF 1; OAF1; basic helix-loop-helix protein OAF1; class B basic;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • GST|His
  • His
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HEY1-467H Recombinant Human HEY1 Protein, GST-His-tagged E.coli GST/His
Human HEY1-1539H Recombinant Human HEY1, His-tagged E.coli His
Human HEY1-29230TH Recombinant Human HEY1, His-tagged E.coli His
Human HEY1-260H Recombinant Human HEY1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HEY1-4715H Recombinant Human HEY1 Protein, GST-tagged Wheat Germ GST
Human HEY1-5575HCL Recombinant Human HEY1 293 Cell Lysate HEK293 N/A
Human HEY1-5576HCL Recombinant Human HEY1 293 Cell Lysate HEK293 N/A
Human HEY1-3528HF Recombinant Full Length Human HEY1 Protein, GST-tagged In Vitro Cell Free System GST 304 amino acids
Human HEY1-5722H Recombinant Human HEY1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Hey1-1118M Recombinant Mouse Hey1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish HEY1-11841Z Recombinant Zebrafish HEY1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HEY1 Related Articles
  • HEY1 Related Signal Pathway

HEY1 involved in several pathways and played different roles in them. We selected most pathways HEY1 participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsCDK8;HEY2;CCNC;HDAC6;HEYL;HEY1;MIB1;ADAM10;JAG1
Constitutive Signaling by NOTCH1 PEST Domain MutantsHDAC5;HEY1;HDAC6;JAG2;HEY2;CCNC;MIB1;JAG1;CDK8
Delta-Notch Signaling PathwayASCL1;ASCL1A;YY1A;HEY2;MAGEA1;ZFPM1;NOV;WDR12;TUBB3
DiseaseSSRP1;STRA6;PSTPIP2;DERL2;AP1B1;JAG1;FMOD;NUP35;DPF1
Diseases of signal transductionOPN1SW;HDAC5;JAG2;CTBP2;TRAT1;KREMEN1;HEY1;RBP1;LRRFIP1
Heart DevelopmentHEY2;HEY1;NKX2;SMYD1;GATA6;NKX2-5;FOXC2;TBX20;TBX5
NOTCH1 Intracellular Domain Regulates TranscriptionHEYL;TLE2;TLE4;TUBB3;TLE3;TLE1;HEY1;HEY2
Notch-mediated HES/HEY networkCTBP1;GATA1;HES6;TLE1;MYB;YY1;HEY1;BGLAP;GATA6

HEY1 has several biochemical functions, for example, microsatellite binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HEY1 itself. We selected most functions HEY1 had, and list some proteins which have the same functions with HEY1. You can find most of the proteins on our site.

Function Related Protein
microsatellite bindingHEYL;HEY2;HEY1
protein bindingTROAP;IL6R;ARL8A;ANXA7;PLEKHG2;COPS4;TXNDC5;FAM125B;SMARCD3
protein dimerization activityNCF4;MYCN;HIF1AL2;HER4.3;BHLHA15;TCF15;MEF2B;ERBB2;HES3
transcription factor activity, RNA polymerase II core promoter sequence-specificPAX7;HEY1;HEY2;NKX3;SMAD3;MEF2C;TFAP2B;MAX;HEYL
transcription factor activity, protein bindingHEY2;HEY1;HEYL
transcription factor activity, sequence-specific DNA bindingATF4;HMG20A;SNAPC5;RUNX1;NR2F6B;ZNF83;HOXB7;SMAD3B;RXRAB
transcription factor bindingJUND;ARHGEF2;TRIB2;RBL1;HMGA1;PPID;DACT2;CSNK2B;CHCHD2

HEY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HEY1.

SMAD9; SKIL; SMAD3; LAPTM5; PRKD2; PTBP3

Campese, AF; Grazioli, P; et al. Mouse Sertoli Cells Sustain De Novo Generation of Regulatory T Cells by Triggering the Notch Pathway Through Soluble JAGGED1. BIOLOGY OF REPRODUCTION 90:-(2014).
Wang, H; Chen, YL; et al. Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. MODERN PATHOLOGY 26:139-147(2013).
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