hey1
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  • Official Full Name
  • hairy/enhancer-of-split related with YRPW motif 1
  • Background
  • This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • HEY1; hairy/enhancer-of-split related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1; BHLHb31; CHF 2; CHF2; HERP2; HESR 1; HESR1; HRT 1; Basic helix loop helix protein OAF1; Cardiovascular helix loop helix factor 2; Cardiovascular helix loop-helix factor 2; Cardiovascular helix-loop-helix factor 2; CHF-2; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split related protein 1; Hairy and enhancer of split-related protein 1; Hairy enhancer-of-split related with YRPW motif protein 1; Hairy related transcription factor 1; Hairy-related transcription factor 1; Hairy/enhancer of split related with YRPW motif 1; HERP 2; HES related repressor protein 1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-1; HEY 1; HEY1_HUMAN; hHRT1; HRT-1; HRT1; MGC1274; OAF 1; OAF1; basic helix-loop-helix protein OAF1; class B basic
Cat.#:HEY1-260HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HEY1 Protein, MYC/DDK-tagged
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Cat.#:HEY1-4715HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HEY1 Protein, GST-tagged
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Cat.#:HEY1-29230THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HEY1, His-tagged
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Cat.#:HEY1-467HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HEY1 Protein, GST-His-tagged
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Cat.#:HEY1-11841ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HEY1
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Cat.#:HEY1-1539HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HEY1, His-tagged
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Cat.#:HEY1-5575HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HEY1 293 Cell Lysate
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Cat.#:HEY1-5576HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HEY1 293 Cell Lysate
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Involved Pathway

HEY1 involved in several pathways and played different roles in them. We selected most pathways HEY1 participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
CDK8; ADAM10; JAG1; HEYL; HDAC5; HDAC6; HEY2; JAG2; MIB1; HEY1
Constitutive Signaling by NOTCH1 PEST Domain Mutants
JAG1; CCNC; HDAC6; JAG2; HDAC5; HEY1; ADAM10; HEYL; HEY2; CDK8
Delta-Notch Signaling Pathway
SMAD3B; JAG1; SAP30; HIVEP3; YY1; ASCL1; CNTF; WDR12; ASCL1A; YY1A
Disease
AMN; EEF2; ACAN; PDCD6IP; SFTPB; JAG1; KREMEN1; CDC37; AP1B1; FGFR1OP
Diseases of signal transduction
HEY1; MYO18A; CUX1; OPN1MW2; TRAT1; OPN1SW; STRA6; CTBP2; LRRFIP1; TRIM24
Heart Development
TBX20; IRX4; HEY1; FOXH1; NKX2-5; NKX2; FOXC2; BMP10; SMYD1; FOXC1
NOTCH1 Intracellular Domain Regulates Transcription
HEY2; TLE2; TLE1; HEY1; TUBB3; HEYL; TLE4; TLE3
Notch-mediated HES/HEY network
GATA1; TLE1; BGLAP; RCAN1; YY1; CTBP1; HES6; HEY1; MYOD1; GATA6

Protein Function

HEY1 has several biochemical functions, for example, microsatellite binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HEY1 itself. We selected most functions HEY1 had, and list some proteins which have the same functions with HEY1. You can find most of the proteins on our site.
Function
Related Protein
Function microsatellite binding
Related Protein HEYL; HEY2; HEY1
Function protein binding
Related Protein PPP1R12C; SFPQ; RAB37; PTPRZ1; ADRA2A; MAPK10; CFL1; HIST2H3C; ZCCHC11; TPCN2
Function protein dimerization activity
Related Protein POLR2J3; MITFA; HER6; ASCL3; TFEB; TCF3A; NHLH2; ATOH8; MXD4; TWIST2
Function transcription factor activity, RNA polymerase II core promoter sequence-specific
Related Protein HEY1; MAX; PAX7; TFAP2B; MEF2C; HEYL; SMAD3; NKX3; HEY2
Function transcription factor activity, protein binding
Related Protein HEY1; HEYL; HEY2
Function transcription factor activity, sequence-specific DNA binding
Related Protein PPARA; GLI4; FOXN2B; HOXB5B; ZFP82; ZNF133; ZFP1; ZKSCAN4; Trl; SIX3
Function transcription factor binding
Related Protein ZFPM1; TRP53; JUNBA; GPX3; NFKBIA; PSMC5; TRIM6; NR0B2A; LEF1; HMGA2

Interacting Protein

HEY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HEY1.
SMAD9; SKIL; SMAD3; LAPTM5; PRKD2; PTBP3

HEY1 Related Articles

Campese, AF; Grazioli, P; et al. Mouse Sertoli Cells Sustain De Novo Generation of Regulatory T Cells by Triggering the Notch Pathway Through Soluble JAGGED1. BIOLOGY OF REPRODUCTION 90:-(2014).
Wang, H; Chen, YL; et al. Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. MODERN PATHOLOGY 26:139-147(2013).