hfe2
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  • Official Full Name
  • hemochromatosis type 2 (juvenile)
  • Background
  • The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
  • Synonyms
  • HFE2; hemochromatosis type 2 (juvenile); hemojuvelin; haemojuvelin; HFE2A; HJV; JH; repulsive guidance molecule c; RGMC; RGM domain family member C; hemochromatosis type 2 protein; MGC23953
Cat.#:HFE2-4722HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HFE2 Protein, GST-tagged
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Cat.#:HFE2-2082HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HFE2 protein, His-tagged
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Cat.#:HFE2-2083HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HFE2 protein, His & T7-tagged
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Cat.#:HFE2-2084HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HFE2 protein, His & GST-tagged
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Cat.#:HFE2-469HTag:His|Fc
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human HFE2 protein, His & Fc-tagged
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Cat.#:HFE2-7288HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HFE2, His tagged
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Cat.#:HFE2-7602MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HFE2 Protein
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Cat.#:HFE2-205CTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus HFE2, His-tagged
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Cat.#:HFE2-4276ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HFE2
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Cat.#:HFE2-2419HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human Hemochromatosis Type 2 (Juvenile), FLAG-tagged
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Cat.#:HFE2-423HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human HFE2 cell lysate
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Cat.#:HFE2-001CCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus HFE2 cell lysate
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Involved Pathway

HFE2 involved in several pathways and played different roles in them. We selected most pathways HFE2 participated on our site, such as Axon guidance, BMP receptor signaling, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with HFE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
PTPRA; SCN2B; ABL1; PTK2; CDK5R1B; MYL12A; RGMA; LAMTOR2; ARPC3; NEFLB
BMP receptor signaling
CALML4; CTDSP1; SKI; CTDSP2; SOSTDC1; RGMB; FST; GREM1; CTDSPL; NOG
Developmental Biology
KCNQ2; EFNA4; HFE2; PEBP1; ARPC2; MEF2AA; RASGRP4; BNIP2; MYOD1; GDF1
Netrin-1 signaling
EZRA; NTN1A; PITPNA; HFE2; RGMA; SIAH2; TRPC4; NTN1B; RNF8; RGMB

Protein Function

HFE2 has several biochemical functions, for example, BMP binding, contributes_to BMP receptor activity, coreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HFE2 itself. We selected most functions HFE2 had, and list some proteins which have the same functions with HFE2. You can find most of the proteins on our site.
Function
Related Protein
Function BMP binding
Related Protein NBL1; TCAP; HFE2; GREM2; BMPR2; GREM1; CER1; GDF5
Function contributes_to BMP receptor activity
Related Protein HFE2
Function coreceptor activity
Related Protein RGMB; RAMP3; CD4; LY96; CD28; PVRL2; LRP5; TGFBR3; CCR8; ACVR2A
Function glycoprotein binding
Related Protein CALR; CNTN1; TGFB1; STX1A; ITGAM; LACRT; LDLR; SDCBP; LGALS1; SERPINA1D
Function protein binding
Related Protein BFSP2; PSMD9; PSMC4; ZCCHC8; FBLN1; POP1; NUFIP2; GYG1; UBA5; CSTF1
Function receptor binding
Related Protein CXCL10; HSPA1B; EDN3; HFE2; Fert2; FGF1B; GIPC1; CD276; POU2F1; SCP2
Function transferrin receptor binding
Related Protein SNX1; RGMA; TF; Trf; SNX2; HFE; SNX4; HFE2; CD81