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HFE2

  • Official Full Name

    hemochromatosis type 2 (juvenile)

  • Overview

    The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
  • Synonyms

    HFE2; hemochromatosis type 2 (juvenile); hemojuvelin; haemojuvelin; HFE2A; HJV; JH; repulsive guidance molecule c; RGMC; RGM domain family member C; hemochromatosis type 2 protein; MGC23953;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293F
  • Human Cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|Fc
  • His|GST
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HFE2-4722H Recombinant Human HFE2 Protein, GST-tagged Wheat Germ GST
Human HFE2-2082H Recombinant Human HFE2 protein, His-tagged E.coli His Lys234~Ser416
Human HFE2-2419H Recombinant Human Hemochromatosis Type 2 (Juvenile), FLAG-tagged Human Cell Flag
Human HFE2-7288H Recombinant Human HFE2 protein(Met1-Ser399), His-tagged Insect Cells C-His Met1-Ser399
Human HFE2-2083H Recombinant Human HFE2 protein, His & T7-tagged E.coli His/T7 Leu29~Ala401 (Accession # Q6ZVN8)
Human HFE2-469H Recombinant Human HFE2 protein, His & Fc-tagged HEK293F His/Fc Gln36~Asp400
Human HFE2-2084H Recombinant Human HFE2 protein, His & GST-tagged E.coli His/GST Gln36~Phe200 (Accession # Q6ZVN8)
Human HFE2-423HCL Recombinant Human HFE2 cell lysate Insect Cell N/A
Mouse HFE2-7602M Recombinant Mouse HFE2 Protein Mammalian Cell His
Mouse HFE2-4145M-B Recombinant Mouse HFE2 Protein Pre-coupled Magnetic Beads HEK293
Mouse HFE2-4145M Recombinant Mouse HFE2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey HFE2-205C Recombinant Cynomolgus HFE2, His-tagged Insect Cell His Met1-Ser400
Cynomolgus Monkey HFE2-001CCL Recombinant Cynomolgus HFE2 cell lysate Insect Cell N/A
Zebrafish HFE2-4276Z Recombinant Zebrafish HFE2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HFE2 involved in several pathways and played different roles in them. We selected most pathways HFE2 participated on our site, such as Axon guidance, BMP receptor signaling, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with HFE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceLRRC4;NTNG1;FRS2A;ITGB1B.1;PAK7;EFNA4;NADL1.1;JAK1;ARPC4
BMP receptor signalingSOSTDC1;RGMB;CTDSP1;SKI;AHSG;CHRDL1;CALML4;CTDSPL;HFE2
Developmental BiologyACTR3;CEBPA;PHB;DNM1;DPYSL2B;TDGF1;RND1L;MYL9;MYL12B
Netrin-1 signalingNTN1A;RGMB;TRPC5;PITPNA;TRPC4;SIAH2;NTN1B;RNF8;EZRA

HFE2 has several biochemical functions, for example, BMP binding, contributes_to BMP receptor activity, coreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HFE2 itself. We selected most functions HFE2 had, and list some proteins which have the same functions with HFE2. You can find most of the proteins on our site.

Function Related Protein
BMP bindingGREM1;NBL1;HFE2;TCAP;GDF5;CER1;GREM2;BMPR2
contributes_to BMP receptor activity
coreceptor activityCXCR7;RGMB;RAMP3;LY96;RAMP1;PVRL2;TGFBR3;PVRL1;CXCR6
glycoprotein bindingRGMA;ACE2;Itgam&Itgb2;TGFB1;FLNA;BBC3;SHB;SERPINA1E;VIM
protein bindingORC1L;NCBP1;BECN1;PLOD3;MYH9;NEDD4L;ACOT8;TSPAN6;NLGN4X
receptor bindingPPP2R4;PLAUR;C3;DHRS4;SLC39A1;LGI1;FASLG;NPY;GRIN2A
transferrin receptor bindingSNX4;TF;HFE2;SNX2;RGMA;Trf;CD81;HFE;SNX1

HFE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HFE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HFE2.

  • Q&As
  • Reviews

Q&As (7)

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How does HFE2 influence the body's response to anemia and hypoxia? 09/01/2022

HFE2 responds to anemia and hypoxic conditions, adjusting iron metabolism to meet physiological needs.

How do alterations in HFE2 expression or function affect the development of liver diseases and cardiomyopathy? 07/10/2021

Changes in HFE2 function can lead to liver diseases and cardiomyopathy due to abnormal iron accumulation.

What is the impact of HFE2 on the regulation of intestinal iron absorption? 04/28/2021

HFE2 impacts intestinal iron absorption, influencing how the body takes up and stores iron.

What are the mechanisms by which HFE2 modulates systemic iron homeostasis? 09/14/2020

HFE2 regulates systemic iron levels, ensuring balance between iron uptake, storage, and utilization.

What role does HFE2 play in the pathogenesis of hereditary hemochromatosis? 08/27/2018

HFE2 is involved in hereditary hemochromatosis, with its dysfunction leading to iron accumulation in organs.

How does HFE2 deficiency or mutation contribute to iron overload disorders? 06/17/2018

Mutations or deficiencies in HFE2 can cause iron overload, disrupting normal iron metabolism.

How does HFE2 (Hemojuvelin) regulate iron metabolism and hepcidin expression in the body? 02/22/2018

HFE2 is crucial in regulating iron metabolism, controlling hepcidin levels to maintain iron homeostasis.

Customer Reviews (3)

Write a review
Reviews
09/23/2022

    Efficient protein purification, delivers consistent yields and purity.

    01/10/2021

      High-quality protein crystallography services, consistently delivers exceptional results.

      06/24/2019

        Critical expertise in protein engineering, unmatched in quality and efficiency.

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