hist1h1a
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  • Official Full Name
  • histone cluster 1, H1a
  • Background
  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
  • Synonyms
  • HIST1H1A; histone cluster 1, H1a; H1 histone family, member 1 , H1F1, histone 1, H1a; histone H1.1; H1.1; H1 histone family member 1; H1F1; HIST1; Histone 1 H1a; Histone cluster 1 H1a; histone 1, H1a; H1 histone family, member 1; H1A
Cat.#:HIST1H1A-231HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HIST1H1A Protein, MYC/DDK-tagged
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Cat.#:HIST1H1A-4773HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HIST1H1A Protein, GST-tagged
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Cat.#:HIST1H1A-7642MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HIST1H1A Protein
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Cat.#:HIST1H1A-2848RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HIST1H1A Protein
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Cat.#:HIST1H1A-2085RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HIST1H1A Protein, His-tagged
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Cat.#:HIST1H1A-5555HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HIST1H1A 293 Cell Lysate
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Involved Pathway

HIST1H1A involved in several pathways and played different roles in them. We selected most pathways HIST1H1A participated on our site, such as Activation of DNA fragmentation factor, Apoptosis, Apoptosis induced DNA fragmentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIST1H1A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of DNA fragmentation factor
HMGB2A; HMGB2; HIST1H1B; HIST1H1A; H1F0; HIST1H1D; DFFA; HIST1H1C; HIST1H1E
Apoptosis
CASP6; VIML; IL1R1; DERL3; HIST1H1E; BAXA; PPP3CA; BIRC7; DFFA; TRAF2
Apoptosis induced DNA fragmentation
HIST1H1D; HIST1H1B; HIST1H1A; HIST1H1E; DFFA; HIST1H1C; HMGB2; H1F0; HMGB2A
Apoptotic execution phase
DSP; VIML; DNM1L; DSG1; STK24; LMNB1; GAS2; STK24B; DSG2; STK26
Cellular Senescence
HIST1H1B; RBBP4; CBX4; KAT5; POT1; AGO3; SUZ12B; TERF1; CBX8B; H3F3B.1
Cellular responses to stress
ATG9B; DNAJB6; RB1CC1; DYNLL2B; WDR45; SUZ12; POT1A; NUP50; PRDX2; ULK1A
DNA Damage/Telomere Stress Induced Senescence
TINF2; HMGA1B; ASF1A; HIRA; ACD; HIST1H1A; POT1A; EP400; HMGA1; HIST1H1C
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
H1F0; ASF1A; EP400; HIRA; HIST1H1B; UBN1; CABIN1; HIST1H1D; HIST1H1C; HMGA1-RS1

Protein Function

HIST1H1A has several biochemical functions, for example, chromatin DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIST1H1A itself. We selected most functions HIST1H1A had, and list some proteins which have the same functions with HIST1H1A. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin DNA binding
Related Protein HIST1H1C; NKAP; H2AFY2; ACTN4; BCL6; MED1; H2AFY; WBP2; HIST1H1D; SRF
Function protein binding
Related Protein PLP2; MUC2; CSGALNACT2; FNBP1; NR0B2; SPZ1; ATP5O; P4HA3; RAB27A; ATXN7L3

Interacting Protein

HIST1H1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIST1H1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HIST1H1A.
SIR2rp1; ADPRH; TERF1; WHSC1L1; TERF2IP; Npro; midostaurin; d2cfj1_9flav; ssrna_ag; CBX4; P/V/C; DFFB; MYC; lt_sv40; NS; NS

HIST1H1A Related Articles

Wang, ZF; Sirotkin, AM; et al. The mouse histone H1 genes: Gene organization and differential regulation. JOURNAL OF MOLECULAR BIOLOGY 271:124-138(1997).