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HK2

  • Official Full Name

    hexokinase 2

  • Overview

    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]
  • Synonyms

    HK2; hexokinase 2; HKII; HXK2; hexokinase-2; HK II; hexokinase type II; hexokinase-2, muscle; muscle form hexokinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HK2-41H Recombinant Human Hexokinase 2, His-tagged E.coli His
Human HK2 -329H Recombinant Human HK2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HK2-13807H Recombinant Human HK2, His-tagged E.coli His C-term-350a.a.
Human HK2-4824H Recombinant Human HK2 Protein, GST-tagged Wheat Germ GST
Human HK2-5508HCL Recombinant Human HK2 293 Cell Lysate HEK293 N/A
Human HK2-3545HF Recombinant Full Length Human HK2 Protein, GST-tagged In Vitro Cell Free System GST 917 amino acids
Human HK2-6652H Recombinant Human HK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HK2-1073H-B Recombinant Human HK2 Protein Pre-coupled Magnetic Beads HEK293
Human HK2-359HFL Recombinant Full Length Human HK2 Protein, C-Flag-tagged Mammalian cells Flag
Human HK2-1073H Recombinant Human HK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HK2-2352H Recombinant Human HK2 Protein (Trp619-Arg917), N-His tagged E.coli N-His Trp619-Arg917
Mouse HK2-7713M Recombinant Mouse HK2 Protein Mammalian Cell His
Mouse HK2-1020M Recombinant Mouse HK2, His-GST-tagged E.coli His/GST
Mouse HK2-4228M Recombinant Mouse HK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hk2-1130M Recombinant Mouse Hk2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HK2-4228M-B Recombinant Mouse HK2 Protein Pre-coupled Magnetic Beads HEK293
Rat HK2-2862R Recombinant Rat HK2 Protein Mammalian Cell His
Rat HK2-2517R-B Recombinant Rat HK2 Protein Pre-coupled Magnetic Beads HEK293
Rat HK2-2517R Recombinant Rat HK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HK2-12296Z Recombinant Zebrafish HK2 Mammalian Cell His
Chicken HK2-5786C Recombinant Chicken HK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HK2 Related Articles
  • HK2 Related Research Area

HK2 involved in several pathways and played different roles in them. We selected most pathways HK2 participated on our site, such as Glycolysis / Gluconeogenesis, Fructose and mannose metabolism, Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisGALM;PFKL;ALDH9A1;ALDH3A1;ALDH9A1A.1;ADH2-2;ALDH3A2;ALDH3A2A;G6PCA.1
Fructose and mannose metabolismPFKFB4L;TSTA3;PFKM;PFKMB;DHRS13L1;PMM2;GMDS;GMPPAB;PFKFB1
Galactose metabolismAKR1B10;B4GALT2;aLA;GLA;LALBA;G6PCA.1;GALM;B4GALT1;G6PC3
Starch and sucrose metabolismAMY2B;AMY1B;HK3;GAA;GBE1;ENPP3;UGT2B7;AGLA;UGP2
Amino sugar and nucleotide sugar metabolismGMPPAA;CHIA.2;GFPT1;RENBP;PGM2;PGM3;AMDHD2;NANS;UAP1L1
Butirosin and neomycin biosynthesisHK1;HK2;HK3;HKDC1
Metabolic pathwaysPCYT1A;PGLS;B3GALT4;LPIN1;NAT2;AKR1B1L;PIGH;PYGMA;POLG
Carbon metabolismPFKMA;GPIA;PSAT1;SDSL;DLAT;FBP2;FBP1B;MTHFR;ACAT1
HIF- signaling pathwayINS;CAMK2A;ANGPT2;PFKL;TF;NOS3;INS1;PIK3CG;HK1
Insulin signaling pathwayIRS4;PIK3R3B;RAPGEF1;INPP5K;PPP1CB;FLOT1B;PIK3R2;PPARGC1A;RPS6KB2
Type II diabetes mellitusINS;IRS2;ADIPOQ;IRS4;INSR;HK1;PKLR;PIK3R1;PRKCZ
Carbohydrate digestion and absorptionG6PC;PIK3CA;PIK3R5;AMY2A4;AMY1B;AMY2A2;PIK3CB;TAS1R2;AMY1A
Central carbon metabolism in cancerNRAS;PDGFRB;NTRK1;SIRT6;SLC7A5;LDHA;MAP2K2;PIK3CD;ERBB2

HK2 has several biochemical functions, for example, ATP binding, fructokinase activity, glucokinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HK2 itself. We selected most functions HK2 had, and list some proteins which have the same functions with HK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCSNK1A1;PIM1;KSR2;PFKFB1;CARS;SNRKA;KIF11;HKDC1;ACVR1BA
fructokinase activityHK2;HKDC1;HK1;HK3
glucokinase activityHK3;HK2;HK1;HKDC1
glucose bindingG6PD;HKDC1;HK1;GYS1;SLC2A8;HK2;G6PDX;UGP2;PYGL
hexokinase activityHK2;HK1;HK3
mannokinase activityHK2;HKDC1;HK3;HK1
protein bindingCFL2;S100A8;SNX17;RANBP3;NLRP3;ITGA2B;RAD50;UQCRB;UBE2D2A

HK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HK2.

UBQLN1; MAGEA12; UBQLN1; ENO1; UBQLN4; HSP90AA1; VCAM1; Tor1aip1; RAD18

Yoon, SO; Jeon, TJ; et al. Analysis of the Roles of Glucose Transporter 1 and Hexokinase 2 in the Metabolism of Glucose by Extrahepatic Bile Duct Cancer Cells. CLINICAL NUCLEAR MEDICINE 40:E178-E182(2015).
Iwamoto, M; Kawada, K; et al. Regulation of F-18-FDG Accumulation in Colorectal Cancer Cells with Mutated KRAS. JOURNAL OF NUCLEAR MEDICINE 55:2038-2044(2014).
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