hla-dqb1
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  • Official Full Name
  • major histocompatibility complex, class II, DQ beta 1
  • Background
  • HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 (later DQ1, and split into DQ5 and DQ6), DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ alpha (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.
  • Synonyms
  • CELIAC1; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA DQB; HLA DQB1; IDDM1; Lymphocyte antigen; Major histocompatibility complex class II beta; Major histocompatibility complex, class II, DQ beta 1; MHC class II antigen DQB1; MHC class II antigen HLA DQ beta 1; MHC class II DQ beta chain; MHC class II HLA DQ beta glycoprotein; MHC class2 antigen; MHC DQ beta; OTTHUMP00000029167; OTTHUMP00000178569; OTTHUMP00000178570; OTTHUMP00000178571; HLA-DQB1; DQw1
Cat.#:HLA-DQB1-12HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HLA-DQB1 protein, GST-tagged
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Cat.#:HLA-DQB1-27714THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HLA-DQB1
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Cat.#:HLA-DQB1-802HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HLA-DQB1 protein, GST-tagged
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Cat.#:HLA-DQB1-5496HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HLA 293 Cell Lysate
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Involved Pathway

HLA-DQB1 involved in several pathways and played different roles in them. We selected most pathways HLA-DQB1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
FCGR3A; MRC2; HLA-DMA; HLA-DRA; C3A.1; COLEC12; FCGR2A; NCF4; CTSL1B; TAP1
Cell adhesion molecules (CAMs)
ITGB1B.2; CLDN11B; NCAM1B; ITGB7; CLDNE; NLGN4A; CADM3; ESAM; NCAM1A; H2-AA
Antigen processing and presentation
HSP90AB1; IFNG; NFYB; KLRC4; PSME2; CALR; HLA-DRB3; HLA-DRB4; H2-Q10; HLA-DPB1
Intestinal i
MHC2A; MAP3K14; AICDA; Icosl; HLA-DPA1; TGFB1; CCL25; CCL27B; CD40; CCR10
ne network for IgA production
ICOSLG; Il2; HLA-DMA; MHC2DCB; HLA-DPA1; MAP3K14; CCL27B; HLA-DQA1; CCL28; HLA-DOB
Type I diabetes mellitus
Il2; PTPRN2; TNF; CD28; Fasl; INS; HLA-E; HLA-F; HLA-B; INS2
Leishmaniasis
IL4; TLR2; HLA-DOA; NCF1; H2-AA; MAP3K7; FCGR1A; IL1B; HLA-DRB4; PRKCB
Toxoplasmosis
LAMB3; PIK3R5; AKT1; CD40LG; MYD88; BIRC2; LAMC1; HSPA6; BAD; MAPK9
Staphylococcus aureus infection
Hc; FCGR2A; FCGR2C; HLA-DRB4; FCGR4; CFB; MASP1; cgr2b; DSG1; SELPLG
Tuberculosis
AKT1; Casp3; RAF1; RFXAP; HLA-DRB4; MAPK3; IFNA1; ITGB2; IL10RA; CASP9
Influenza A
GSK3B; IFNB; EIF2AK1; MAPK8; IKBKB; VDAC1; IFNA2; AKT2; IFNGR2; TNFRSF10D
HTLV-I infection
DVL1; WNT7A; CDC23; APC; NFATC1; HLA-C; CD3D; SMAD3; WNT2B; HLA-DMB
Herpes simplex infection
FADD; GLTSCR2; CLOCKB; OAS1B; Ifna11; OAS1A; MCRS1; DAXX; HLA-DQA2; FASLG
Epstein-Barr virus infection
SND1; CDK1; PSMD1; CD58; NFKB2; HLA-C; HLA-DRA; PRKACA; RELA; RELB
Asthma
HLA-DMB; HLA-DRB1; HLA-DOA; PRG2; IL5; MS4A2; HLA-DQA1; IL3; HLA-DQB1; H2-AB1
Autoi
HLA-A; HLA-DPB1; FAS; PRF1; H2-AA; TSHB; IFNA12; HLA-DRB5; IFNA16; IFNA6
ne thyroid disease
H2-AB1; CD86; HLA-DOA; IFNA17; Il2; Ifna11; HLA-DRB1; HLA-B; IFNA21; HLA-DQB1
Inflammatory bowel disease (IBD)
TGFB1; STAT1; TLR5; HLA-DRB3; TLR4; IFNG; STAT6; IL12RB1; IL12RB2; HLA-DPA1
Systemic lupus erythematosus
C1S; C9; FCGR4; TRIM21; HLA-DQA2; SSB; HLA-DRB3; CD86; HIST1H2AD; ACTN3
Rheumatoid arthritis
HLA-DRB5; IL6; H2-AA; IL17A; TGFB3; VEGFA; HLA-DPB1; GM-CSF; CCL2; IL15
Allograft rejection
MICA; HLA-F; HLA-DPA1; HLA-DQA2; CD28; H2-Q10; TNF; IL10; HLA-DRB1; IL5
Graft-versus-host disease
KLRC1; TNF; KIR2DL1; KIR3DL2; IFNG; FASLG; HLA-DMB; HLA-F; CD28; KIR2DL3
Viral myocarditis
HLA-DOA; BID; CD40LG; HLA-A; HLA-E; MYH7; RAC2; LAMA2; ABL2; CAV1

Protein Function

HLA-DQB1 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQB1 itself. We selected most functions HLA-DQB1 had, and list some proteins which have the same functions with HLA-DQB1. You can find most of the proteins on our site.
Function
Related Protein
Function MHC class II receptor activity
Related Protein HLA-DQA2; HLA-DRA; HLA-DPA1; HLA-DQB1; HLA-DRB1; HLA-DOB; HLA-DQB2; HLA-DRB3; HLA-DOA; HLA-DQA1
Function peptide antigen binding
Related Protein H2-Q10; MHC1UEA; MHC1ZE; H2-AB1; HLA-DQB1; MHC1UBA; AZGP1; MHC1ZFA; H2-AA; HLA-DRB4

Interacting Protein

HLA-DQB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQB1.
HLA-DQA1