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HLA-DRB3

  • Official Full Name

    HLA-DRB3 major histocompatibility complex, class II, DR beta 3 [ Homo sapiens ]

  • Overview

    HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
  • Synonyms

    major histocompatibility complex, class II, DR beta 3; 4951; MGC117330; DR7; MHC class II antigen DRB3; human leucocyte antigen DRB3; MHC class II HLA-DR beta 3 chain; MHC class II antigen DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DRB1-7 beta chain; HLA-DR3B;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-DRB3-13823H Recombinant Human HLA-DRB3, His-tagged E.coli His 31-228a.a.
Human HLA-DRB3-1210H Recombinant Human HLA-DRB3, GST-tagged Wheat Germ GST
Human HLA-DRB3-798HCL Recombinant Human HLA-DRB3 cell lysate N/A
Human HLA-DRB3-234HF Recombinant Full Length Human HLA-DRB3 Protein, GST-tagged In Vitro Cell Free System GST 1 a.a. - 266 a.a.
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-DRB3 Related Articles

HLA-DRB3 involved in several pathways and played different roles in them. We selected most pathways HLA-DRB3 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeHLA-B;SEC61G;OLR1;TLR2-2;TUBA1C;FCGR4;HLA-DOB;TUBB2B;ATP6AP1
Cell adhesion molecules (CAMs)SDC2;PVRL3;NLGN4A;SELL;CNTNAP2A;HLA-DQB1;CNTNAP2;PTPRM;F11R
Antigen processing and presentationHLA-DRB1;HSPA8;HSP90AA1;CD74;RFXAP;CTSS;CTSB;HLA-A;HLA-C
Hematopoietic cell lineageGP1BA;IL5RA;IL6;CD1A;CD4;CSF1;IL1R1;TNF;MS4A1
Intestinal iAICDA;HLA-DMA;TNFSF13;HLA-DQB1;IL6;ICOSLG;MAP3K14;IL4;ITGB7
ne network for IgA productionCCL28;MHC2DCB;Icosl;HLA-DQA1;HLA-DPA1;IL15;HLA-DRB3;BMA2;ICOSLG
Type I diabetes mellitusHLA-DRA;CD86;HLA-B;HLA-DMA;GZMB;HLA-DRB1;PTPRN2;FAS;CD80
LeishmaniasisITGB2;TNF;STAT1;TRAF6;PRKCB;ITGB1;HLA-DRB1;MAP3K7;FCGR2C
ToxoplasmosisIL10RB;CD40LG;HLA-DPB1;MAP2K6;MAPK3;MAPK8;HSPA2;NOS2;PIK3CD
Staphylococcus aureus infectionC1QA;HLA-DPB1;FGG;FCGR2C;C1RA;FCGR3A;C3AR1;DSG1C;C3
TuberculosisBCL2;NFYB;IFNGR1;ATP6V0A4;ITGAM;ATP6V0D1;CAMP;CD209A;IFNA1
Influenza AIRF3;NXF1;MAP2K1;DNAJB1;IFNA16;HLA-DRB4;IFNA6;CCL5;EIF2AK3
HTLV-I infectionPOLD1;SLC25A4;SRF;PPP3CA;HLA-DRB1;HLA-DOA;TCF3;HLA-DRB4;HLA-DQA1
Herpes simplex infectionNFKBIA;Fasl;SOCS3B;BLB2;HLA-DOB;PER1B;HLA-DPB1;POLR2A;IFNA6
Epstein-Barr virus infectionHLA-DQA1;EIF2AK3;POLR2F;ENTPD1;POLR2J2;POLR3C;HSPA6;HLA-G;YWHAH
AsthmaEPX;HLA-DOA;HLA-DMB;FCER1G;FCER1A;HLA-DRB1;HLA-DRB4;HLA-DRB5;MS4A2
AutoiGZMB;HLA-DRB5;HLA-DQB1;HLA-DMB;IFNA13;HLA-DPA1;FASLG;HLA-DRB3;CD80
ne thyroid diseaseIL4;FAS;H2-Q10;IFNA14;CD28;HLA-DOA;HLA-DQA1;Ifna11;HLA-DQA2
Inflammatory bowel disease (IBD)MAF;HLA-DRB4;STAT1;IL23R;IL22;TLR2;HLA-DRB3;IL21;IL6
Systemic lupus erythematosusHIST1H4A;HIST1H3G;HIST2H4;HIST1H3E;HIST1H4N;GM14477;HIST1H4B;HIST2H2AC;C8G
Rheumatoid arthritisHLA-DQA1;ATP6AP1;ATP6V1G2;HLA-DQA2;ATP6V1H;ATP6V0A4;IL1B;Il23a; Il12b;CXCL6
Allograft rejectionHLA-DQA2;IL4;HLA-DOA;HLA-DOB;CD80;CD86;H2-AB1;Il2;IL12A
Graft-versus-host diseaseHLA-DQA1;HLA-DMB;GZMB;HLA-DRB1;KIR3DL2;HLA-DRB5;KIR2DL3;HLA-G;KLRD1
Viral myocarditisHLA-DRB1;ITGB2;HLA-A;HLA-DRB5;EIF4G3;HLA-DOB;ACTG1;HLA-DRB3;RAC3

HLA-DRB3 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRB3 itself. We selected most functions HLA-DRB3 had, and list some proteins which have the same functions with HLA-DRB3. You can find most of the proteins on our site.

Function Related Protein
MHC class II receptor activityHLA-DRA;HLA-DOB;HLA-DRB4;KRT17;HLA-DRB3;HLA-DQA1;HLA-DQB2;HLA-DOA;HLA-DQA2
peptide antigen bindingCD209;MHC1UXA2;MHC1UHA;H2-AA;HLA-DPB1;HLA-F;BF2;MHC1ZDA;HLA-DRA
protein bindingRGS1;SMC3;IFITM1;PLCG2;FAM108A1;RAD51L3;CLIC3;OCA2;KRTAP19-7

HLA-DRB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRB3.

MAP3K13; CDCA8; ZDHHC17

Kosmoliaptsis, V; Gjorgjimajkoska, O; et al. Impact of donor mismatches at individual HLA-A, -B, -C, -DR, and -DQ loci on the development of HLA-specific antibodies in patients listed for repeat renal transplantation. KIDNEY INTERNATIONAL 86:1039-1048(2014).
Baxter-Lowe, LA; Cecka, M; et al. Center-Defined Unacceptable HLA Antigens Facilitate Transplants for Sensitized Patients in a Multi-Center Kidney Exchange Program. AMERICAN JOURNAL OF TRANSPLANTATION 14:1592-1598(2014).
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