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HNF1A

  • Official Full Name

    HNF1 homeobox A

  • Overview

    LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1), TCF3, and TCF4 (1). LEF1 and TCF1 were originally iden
  • Synonyms

    HNF1A; HNF1 homeobox A; MODY3, TCF1, transcription factor 1, hepatic; LF B1, hepatic nuclear factor (HNF1), albumin proximal factor; hepatocyte nuclear factor 1-alpha; HNF1; LFB1; HNF-1-alpha; albumin proximal factor; hepatic nuclear factor 1; transcript;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HNF1A-4891H Recombinant Human HNF1A Protein, GST-tagged Wheat Germ GST
Human HNF1A-5461HCL Recombinant Human HNF1A 293 Cell Lysate HEK293 N/A
Human HNF1A-2249H Recombinant Human HNF1A Protein, His-tagged E.coli N-His Glu71-Arg271
Mouse HNF1A-7750M Recombinant Mouse HNF1A Protein Mammalian Cell His
Mouse Hnf1a-3417M Recombinant Mouse Hnf1a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HNF1A-4253M-B Recombinant Mouse HNF1A Protein Pre-coupled Magnetic Beads HEK293
Mouse Hnf1a-1633M Recombinant Mouse Hnf1a Protein, His&GST-tagged E.coli N-His&GST Asp56-Arg321
Mouse HNF1A-4253M Recombinant Mouse HNF1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HNF1A-2876R Recombinant Rat HNF1A Protein Mammalian Cell His
Rat HNF1A-2531R Recombinant Rat HNF1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HNF1A-2531R-B Recombinant Rat HNF1A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HNF1A-9486Z Recombinant Zebrafish HNF1A Mammalian Cell His
Chicken HNF1A-2372C Recombinant Chicken HNF1A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HNF1A Related Articles
  • HNF1A Related Research Area

HNF1A involved in several pathways and played different roles in them. We selected most pathways HNF1A participated on our site, such as Signaling pathways regulating pluripotency of stem cells, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling pathways regulating pluripotency of stem cellsWNT6;ID2;IGF1R;WNT9B;OTX1;ACVR2B;WNT5B;WNT8B;PIK3R5
Maturity onset diabetes of the youngINS1;HES1;INS2;RFX6;NKX6-1;NR5A2;MAFA;HNF4A;MNX1

HNF1A has several biochemical functions, for example, DNA binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HNF1A itself. We selected most functions HNF1A had, and list some proteins which have the same functions with HNF1A. You can find most of the proteins on our site.

Function Related Protein
DNA bindingSMYD1;HOXA10B;DEDD;ZBTB6;ZNF367;ZNF383;ERG;MTF2;POLD2
protein bindingMYBPHL;KIAA1967;OGT;SREBF2;BID;H2-AA;CALM2;SLC30A2;CALCRL
protein dimerization activityLMLN;NCF4;NEUROG2;DAO;CREB3;MGAA;RIMKLB;CELSR1;BTRC
protein heterodimerization activityALX1;SPNA1;EXT1;MAPK4;AXL;BAXA;TFAP2B;BRAF;MAFGB
protein homodimerization activityGCA;CCL5;VPS24;NPM1;AGXT;NAMPT;TPR;INHBB;GSTM1
transcription factor activity, sequence-specific DNA bindingAHR;NKX2-6;SRF;ETS1;HOMEZ;NR2F2;BARX1;GATA3;RCAN1
transcription regulatory region DNA bindingHIVEP3;WNT5A;IKZF2;IKZF1;RBBP5;BCL11AB;SNCA;Arid4b;KLF4
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingFLI1;ZFP639;BATF;ETV4;HOXA7;NUCKS1;MEF2A;CEBPZ;FOXJ2

HNF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HNF1A.

DYRK1B; PCBD1; PCBD2; PROX1; RNF14; angt_human_apre-2_dna-probe; SNRPA1; CALM1; FABP5; RYR3

Simaite, D; Kofent, J; et al. Recessive Mutations in PCBD1 Cause a New Type of Early-Onset Diabetes. DIABETES 63:3557-3564(2014).
Shankar, RK; Ellard, S; et al. Digenic heterozygous HNF1A and HNF4A mutations in two siblings with childhood-onset diabetes. PEDIATRIC DIABETES 14:535-538(2013).
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