HNF1A
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Official Full Name
HNF1 homeobox A -
Overview
LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1), TCF3, and TCF4 (1). LEF1 and TCF1 were originally iden -
Synonyms
HNF1A;HNF1 homeobox A;MODY3, TCF1, transcription factor 1, hepatic;LF B1, hepatic nuclear factor (HNF1), albumin proximal factor;hepatocyte nuclear factor 1-alpha;HNF1;LFB1;HNF-1-alpha;albumin proximal factor;hepatic nuclear factor 1;transcript
Recombinant Proteins
- Chicken
- Rat
- Human
- Mouse
- Zebrafish
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HNF1A-2372C | Recombinant Chicken HNF1A | Mammalian Cells | Chicken | His |
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| HNF1A-2876R | Recombinant Rat HNF1A Protein | Mammalian Cells | Rat | His |
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| HNF1A-4891H | Recombinant Human HNF1A Protein, GST-tagged | Wheat Germ | Human | GST | 532-631 a.a. |
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| HNF1A-7750M | Recombinant Mouse HNF1A Protein | Mammalian Cells | Mouse | His |
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| HNF1A-9486Z | Recombinant Zebrafish HNF1A | Mammalian Cells | Zebrafish | His |
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| HNF1A-5461HCL | Recombinant Human HNF1A 293 Cell Lysate | HEK293 | Human | Non |
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| Hnf1a-1633M | Recombinant Mouse Hnf1a Protein, His&GST-tagged | E.coli | Mouse | GST&His | Asp56-Arg321 |
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| HNF1A-2249H | Recombinant Human HNF1A Protein, His-tagged | E.coli | Human | His | Glu71-Arg271 |
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| HNF1A-2531R | Recombinant Rat HNF1A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| HNF1A-2531R-B | Recombinant Rat HNF1A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Hnf1a-3417M | Recombinant Mouse Hnf1a Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| HNF1A-4253M | Recombinant Mouse HNF1A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| HNF1A-4253M-B | Recombinant Mouse HNF1A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HNF1A involved in several pathways and played different roles in them. We selected most pathways HNF1A participated on our site, such as Signaling pathways regulating pluripotency of stem cells,Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | FGFR1,FGFR4,SMAD5,INHBB,PIK3CA,JARID2,PIK3R3,FZD9,POU5F1,MAPK12 |
| Maturity onset diabetes of the young | HES1,MAFA,BHLHA15,NKX6,PAX4,ONECUT1,MNX1,PAX6,IAPP,HNF1B |
Protein Function
HNF1A has several biochemical functions, for example, DNA binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HNF1A itself. We selected most functions HNF1A had, and list some proteins which have the same functions with HNF1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein dimerization activity | SREBF2,HER1,HER11,ATOH7,HER6,STAT5B,POLR1C,GRIN2A,OLIG4,MESPAB |
| protein heterodimerization activity | HIST1H4F,VEGFB,KCNN1,ARNT,ABTB2,TIMELESS,Pdgfa&Pdgfb,GCLM,NPM1,TAF6 |
| DNA binding | SMAD9,ADNP,FOXB1A,SP140,LIN28A,ZSCAN4D,SOX15,ZNF703,PPARD,ZNF488 |
| transcription regulatory region DNA binding | HINFP,TCF7,HIVEP3,GRHL1,NFKB1,NR1H3,TP63,RREB1,NKX3-1,CALCOCO1 |
| transcription factor activity, sequence-specific DNA binding | TAF6,NFE2L1A,KLF9,NFE2L2,SRF,MSC,SIM1A,NR1D4A,NR2F6A,POU2F2 |
| protein binding | PDGFC,SAP18,FUBP3,ATXN10,RGS1,C2orf51,HMGB4,KRT16,OTUB1,BCL2L11 |
| protein homodimerization activity | ASCL1,ACHE,MIXL1,SLIT2,AGXT,CUL3,GSTM2,TYR,CDA,TCF3A |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NKX2,MYB,PPARA,STK16,ONECUTL,TFAM,NRF1,PITX1,CAMTA1,PAX5 |
Interacting Protein
HNF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HNF1A.
DYRK1B;PCBD1;PCBD2;PROX1;RNF14;angt_human_apre-2_dna-probe;SNRPA1;CALM1;FABP5;RYR3
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References
- Simaite, D; Kofent, J; et al. Recessive Mutations in PCBD1 Cause a New Type of Early-Onset Diabetes. DIABETES 63:3557-3564(2014).
- Shankar, RK; Ellard, S; et al. Digenic heterozygous HNF1A and HNF4A mutations in two siblings with childhood-onset diabetes. PEDIATRIC DIABETES 14:535-538(2013).
