HNF1A Protein, HNF1 homeobox A

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HNF1A

Official Full Name	HNF1 homeobox A
Background	LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1), TCF3, and TCF4 (1). LEF1 and TCF1 were originally iden
Synonyms	HNF1A; HNF1 homeobox A; MODY3, TCF1, transcription factor 1, hepatic; LF B1, hepatic nuclear factor (HNF1), albumin proximal factor; hepatocyte nuclear factor 1-alpha; HNF1; LFB1; HNF-1-alpha; albumin proximal factor; hepatic nuclear factor 1; transcript

Species :
Chicken
Human
Mouse
Rat
Zebrafish

Source :
HEK293
Mammalian Cell
Wheat Germ

Tag :
GST
His
N/A

Species	Cat.#	Product name	Source (Host)	Tag
Human	HNF1A-4891H	Recombinant Human HNF1A Protein, GST-tagged	Wheat Germ	GST
Human	HNF1A-5461HCL	Recombinant Human HNF1A 293 Cell Lysate	HEK293	N/A
Mouse	HNF1A-7750M	Recombinant Mouse HNF1A Protein	Mammalian Cell	His
Rat	HNF1A-2876R	Recombinant Rat HNF1A Protein	Mammalian Cell	His
Chicken	HNF1A-2372C	Recombinant Chicken HNF1A	Mammalian Cell	His
Zebrafish	HNF1A-9486Z	Recombinant Zebrafish HNF1A	Mammalian Cell	His

Involved Pathway Protein Function Interacting Protein HNF1A Related Articles

HNF1A involved in several pathways and played different roles in them. We selected most pathways HNF1A participated on our site, such as Signaling pathways regulating pluripotency of stem cells, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells	FGFR4; FZD9; BMPR1A; FGF2; SOX2; ACVR1; FZD8; HAND1; GSK3B; SMAD5
Maturity onset diabetes of the young	NEUROD1; PAX4; HES1; IAPP; INS2; PDX1; MNX1; MAFA; PAX6; NR5A2

HNF1A has several biochemical functions, for example, DNA binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HNF1A itself. We selected most functions HNF1A had, and list some proteins which have the same functions with HNF1A. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZBTB5; ZNF286A; IRF6; DMRT2B; ZNF37A; HES3; MAFBA; SURF6; HIST1H2B5; ZFP35
protein binding	GDAP2; GALNT2; PSMD14; CD226; KLHL2; TAF13; VSIG4; SLC39A13; GFI1B; RNF19B
protein dimerization activity	PEX3; PTF1A; ATOH1B; HER6; PDCD6; FBXW11A; HER2; TFE3; MEF2AA; FERD3L
protein heterodimerization activity	MAFGA; ERBB3; HIST1H2AL; NPAS4; CHRNA3; TIRAP; Bcl2a1b; PKNOX1; NOTCH4; APITD1
protein homodimerization activity	ATIC; MYO7A; KCNK9; DPP4; PVRL2; NACC2; HRSP12; Bcl2a1b; MCL1; APOA1BP
transcription factor activity, sequence-specific DNA binding	ZSCAN20; SOX11B; SOX1; KLF2; CIR1; Trl; POU2F1B; FOXI1; MECP2; TAF1B
transcription regulatory region DNA binding	ASH2L; ZNF217; SERPINB1A; ATF3; STAT3; JUND; SIX1; ATMIN; HHEX; WNT11
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	HOXC13; GLI3; PPARA; HNRNPK; EGR1; AKNA; MYOG; FOSL1; KLF5; MEF2B

HNF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HNF1A.

DYRK1B; PCBD1; PCBD2; PROX1; RNF14; angt_human_apre-2_dna-probe; SNRPA1; CALM1; FABP5; RYR3

Simaite, D; Kofent, J; et al. Recessive Mutations in PCBD1 Cause a New Type of Early-Onset Diabetes. DIABETES 63:3557-3564(2014).

Shankar, RK; Ellard, S; et al. Digenic heterozygous HNF1A and HNF4A mutations in two siblings with childhood-onset diabetes. PEDIATRIC DIABETES 14:535-538(2013).

HNF1A Protein, HNF1 homeobox A

HNF1A

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HNF1A

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