HNF1A Protein, HNF1 homeobox A


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Official Full Name HNF1 homeobox A
Background LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1), TCF3, and TCF4 (1). LEF1 and TCF1 were originally iden
Synonyms HNF1A; HNF1 homeobox A; MODY3, TCF1, transcription factor 1, hepatic; LF B1, hepatic nuclear factor (HNF1), albumin proximal factor; hepatocyte nuclear factor 1-alpha; HNF1; LFB1; HNF-1-alpha; albumin proximal factor; hepatic nuclear factor 1; transcript
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HNF1A-4891H Recombinant Human HNF1A Protein, GST-tagged Wheat Germ GST
    Human HNF1A-5461HCL Recombinant Human HNF1A 293 Cell Lysate HEK293 N/A
    Mouse HNF1A-7750M Recombinant Mouse HNF1A Protein Mammalian Cell His
    Rat HNF1A-2876R Recombinant Rat HNF1A Protein Mammalian Cell His
    Chicken HNF1A-2372C Recombinant Chicken HNF1A Mammalian Cell His
    Zebrafish HNF1A-9486Z Recombinant Zebrafish HNF1A Mammalian Cell His

    HNF1A involved in several pathways and played different roles in them. We selected most pathways HNF1A participated on our site, such as Signaling pathways regulating pluripotency of stem cells, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells FGFR4; FZD9; BMPR1A; FGF2; SOX2; ACVR1; FZD8; HAND1; GSK3B; SMAD5
    Maturity onset diabetes of the young NEUROD1; PAX4; HES1; IAPP; INS2; PDX1; MNX1; MAFA; PAX6; NR5A2

    HNF1A has several biochemical functions, for example, DNA binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HNF1A itself. We selected most functions HNF1A had, and list some proteins which have the same functions with HNF1A. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZBTB5; ZNF286A; IRF6; DMRT2B; ZNF37A; HES3; MAFBA; SURF6; HIST1H2B5; ZFP35
    protein binding GDAP2; GALNT2; PSMD14; CD226; KLHL2; TAF13; VSIG4; SLC39A13; GFI1B; RNF19B
    protein dimerization activity PEX3; PTF1A; ATOH1B; HER6; PDCD6; FBXW11A; HER2; TFE3; MEF2AA; FERD3L
    protein heterodimerization activity MAFGA; ERBB3; HIST1H2AL; NPAS4; CHRNA3; TIRAP; Bcl2a1b; PKNOX1; NOTCH4; APITD1
    protein homodimerization activity ATIC; MYO7A; KCNK9; DPP4; PVRL2; NACC2; HRSP12; Bcl2a1b; MCL1; APOA1BP
    transcription factor activity, sequence-specific DNA binding ZSCAN20; SOX11B; SOX1; KLF2; CIR1; Trl; POU2F1B; FOXI1; MECP2; TAF1B
    transcription regulatory region DNA binding ASH2L; ZNF217; SERPINB1A; ATF3; STAT3; JUND; SIX1; ATMIN; HHEX; WNT11
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding HOXC13; GLI3; PPARA; HNRNPK; EGR1; AKNA; MYOG; FOSL1; KLF5; MEF2B

    HNF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HNF1A.

    DYRK1B; PCBD1; PCBD2; PROX1; RNF14; angt_human_apre-2_dna-probe; SNRPA1; CALM1; FABP5; RYR3

    Simaite, D; Kofent, J; et al. Recessive Mutations in PCBD1 Cause a New Type of Early-Onset Diabetes. DIABETES 63:3557-3564(2014).
    Shankar, RK; Ellard, S; et al. Digenic heterozygous HNF1A and HNF4A mutations in two siblings with childhood-onset diabetes. PEDIATRIC DIABETES 14:535-538(2013).

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