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HNRNPM

  • Official Full Name

    heterogeneous nuclear ribonucleoprotein M

  • Overview

    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants.
  • Synonyms

    HNRNPM; heterogeneous nuclear ribonucleoprotein M; HNRPM, NAGR1; CEA receptor; CEAR; HNRNPM4; HNRPM4; HTGR1; hnRNA-binding protein M4; N-acetylglucosamine receptor 1; heterogenous nuclear ribonucleoprotein M4; HNRPM; NAGR1; hnRNP M; DKFZp547H118;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HNRNPM-5432H Recombinant Human HNRNPM protein, His-tagged E.coli His
Human HNRNPM-5438H Recombinant Human HNRNPM protein, GST-tagged Wheat Germ GST
Human HNRNPM-1244H Recombinant Human HNRNPM Protein, His-SUMO-tagged E.coli His/SUMO
Human HNRNPM-5440HCL Recombinant Human HNRNPM 293 Cell Lysate HEK293 N/A
Human HNRNPM-728HF Recombinant Full Length Human HNRNPM Protein, GST-tagged In Vitro Cell Free System GST 730 amino acids
Zebrafish HNRNPM-8171Z Recombinant Zebrafish HNRNPM Mammalian Cell His
Chicken HNRNPM-2621C Recombinant Chicken HNRNPM Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HNRNPM involved in several pathways and played different roles in them. We selected most pathways HNRNPM participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SpliceosomeHSPA6;SLU7;SFRS3B;SNRNP27;HSP70L;SRSF6A;HSPA8;RP9;NHP2L1

HNRNPM has several biochemical functions, for example, RNA binding, antigen binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPM itself. We selected most functions HNRNPM had, and list some proteins which have the same functions with HNRNPM. You can find most of the proteins on our site.

Function Related Protein
RNA bindingCPEB1B;SCAF1;ADARB1A;CNOT4B;RPL34;RPL22;PABPC1A;UBR5;DDX19B
antigen bindingIGJ;Ighg;IGKV1-5;IGKC;LILRB4;IGHM;LILRA2;FCN2;FCN3
nucleotide bindingRAB5AA;CPEB1B;NAIP6;UMPS;GNAIA;ENOX2;LMTK2;PTBP1A;DDX39AA
poly(A) RNA bindingSRPK1;NUFIP2;CDC42EP4;DDX24;HNRNPC;MRPL11;IGF2BP3;Api5;PEF1
protein bindingPIK3R3;PPP2R4;MPP5;TACR3;ORC1L;PRKD3;UNC45B;FGFR3;ZFYVE19
protein domain specific bindingUNC13A;CASP2;SHC4;XPO1;PPP3R1;Akap2;CACNB2;ARFIP2;POU2F2

HNRNPM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPM here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPM.

LMO2; CDC5L; PLRG1; 4005; HNRNPF

  • Q&As
  • Reviews

Q&As (7)

Ask a question
In which cellular compartments is HNRNPM predominantly located? 10/19/2021

HNRNPM is primarily located in the nucleus but can shuttle between the nucleus and cytoplasm.

How does HNRNPM influence RNA splicing? 03/03/2021

It binds to pre-mRNA, influencing splice site selection and alternative splicing.

What role does HNRNPM play in alternative splicing? 02/27/2021

It regulates alternative splicing by binding to specific RNA sequences.

Are there known genetic mutations that impact HNRNPM function? 08/08/2020

Mutations and altered expression of HNRNPM have been linked to various cancers.

What is the primary role of HNRNPM in cellular processes? 06/20/2020

HNRNPM is involved in RNA processing, including splicing, transport, and stability.

What research methods are commonly used to study HNRNPM? 11/15/2019

Common research methods include RNA immunoprecipitation, western blot, and functional assays.

How is HNRNPM implicated in cancer progression? 01/24/2019

HNRNPM can promote cancer progression by altering splicing to produce oncogenic isoforms.

Customer Reviews (3)

Write a review
Reviews
04/24/2022

    Excellent in biochemical assays.

    10/29/2020

      Satisfied, product as described.

      03/11/2019

        Great for scientific research.

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