hoxd12
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  • Official Full Name
  • homeobox D12
  • Background
  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5 end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.
  • Synonyms
  • HOXD12; homeobox D12; homeo box D12 , HOX4H; homeobox protein Hox-D12; Homeobox protein Hox D12; Hox 4.7, mouse, homolog of; Hox 4H; HOX4H; homeo box D12; OTTHUMP00000217531; OTTHUMP00000217532; homeobox protein Hox-4H; Hox-4.7, mouse, homolog of
Cat.#:HOXD12-7816MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HOXD12 Protein
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Cat.#:HOXD12-6801CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HOXD12
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Protein Function

HOXD12 has several biochemical functions, for example, DNA binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXD12 itself. We selected most functions HOXD12 had, and list some proteins which have the same functions with HOXD12. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein BCL3; CSDC2; FOXA1; DLX2B; NKX2-1; ZNF333; TSG101; ZFP184; ZFP110; MCM8
Function protein binding
Related Protein CHMP4A; SKIL; GSTO2; SMAD4; DCD; RRAGD; SEMA4A; PFTK1; ROCK2; ZNF404
Function sequence-specific DNA binding
Related Protein FOXI3B; HOXD10; CTCFL; HIC1; HOXD4; HOXA10B; HOXA4; SOX7; DLX2B; NR2F1B

Interacting Protein

HOXD12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXD12 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXD12.
Meis1; Meis1

HOXD12 Related Articles

Galbo, T; Pedersen, IL; et al. Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels. EUROPEAN JOURNAL OF HISTOCHEMISTRY 54:92-98(2010).