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HRG

  • Official Full Name

    histidine-rich glycoprotein

  • Overview

    This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit roset
  • Synonyms

    HRG; histidine-rich glycoprotein; DKFZp779H1622; Histidine proline rich glycoprotein; Histidine rich glycoprotein; HPRG; HRGP; Thrombophilia due to elevated HRG; OTTMUSP00000045931; histidine-proline-rich glycoprotein; D16jh2; D18020; AI265597; AW413091; THPH11;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HRG-753H Recombinant Human HRG, His tagged Human Cell His
Human HRG-514H Recombinant Human HRG protein, His-tagged HEK293F His Val19~Lys525
Human HRG-5032H Recombinant Human HRG Protein, GST-tagged Wheat Germ GST
Human HRG-7862H Recombinant Human HRG protein, His & GST-tagged E.coli His/GST Ala18~Gly254 (Accession # P04196)
Human HRG-593H Recombinant Human HRG protein, His-tagged HEK293F His Val19~Lys525
Human HRG-332H Recombinant Human Histidine-Rich Glycoprotein E.coli N/A
Human HRG-2790HCL Recombinant Human HRG cell lysate Human Cell N/A
Human HRG-1098H-B Recombinant Human HRG Protein Pre-coupled Magnetic Beads HEK293
Human HRG-2133H Recombinant Human HRG Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HRG-1098H Recombinant Human HRG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HRG-4707H Recombinant Human HRG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HRG-2403H Recombinant Human HRG Protein (Ala18-Gly254), N-GST tagged E.coli N-GST Ala18-Gly254
Human HRG-3660HF Recombinant Full Length Human HRG Protein, GST-tagged In Vitro Cell Free System GST 525 amino acids
Human HRG-799HFL Recombinant Full Length Human HRG Protein, C-Flag-tagged Mammalian cells Flag
Mouse Hrg-452M Active Recombinant Mouse Hrg, His-tagged Mammalian cells His
Mouse HRG-7847M Recombinant Mouse HRG Protein Mammalian Cell His
Mouse Hrg-7863M Recombinant Mouse Hrg protein, His & GST-tagged E.coli His/GST Arg93~Ser328 (Accession # Q9ESB3)
Mouse Hrg-3438M Recombinant Mouse Hrg Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Hrg-4316M-B Recombinant Mouse Hrg Protein Pre-coupled Magnetic Beads HEK293
Mouse Hrg-967M Recombinant Mouse Hrg Protein, His-tagged HEK293F N-His Leu19-Lys525
Mouse Hrg-4316M Recombinant Mouse Hrg Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HRG-4317M Recombinant Mouse HRG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HRG-4317M-B Recombinant Mouse HRG Protein Pre-coupled Magnetic Beads HEK293
Rat HRG-2910R Recombinant Rat HRG Protein Mammalian Cell His
Rat Hrg-7864R Recombinant Rat Hrg protein, His & T7-tagged E.coli His/T7 Ile106~Pro302 (Accession # Q99PS8)
Rat Hrg-519R Recombinant Rat Hrg protein, His-tagged HEK293F His
Rat HRG-2565R Recombinant Rat HRG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HRG-425R Recombinant Rat HRG Protein, His-tagged HEK293 His Met1-Lys525
Rat HRG-2565R-B Recombinant Rat HRG Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HRG Related Articles

HRG involved in several pathways and played different roles in them. We selected most pathways HRG participated on our site, such as Dissolution of Fibrin Clot, Hemostasis, Platelet activation, signaling and aggregation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HRG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Dissolution of Fibrin ClotS100A10B;ANXA2A;ANXA2B;S100A10;S100A10A;SERPINF2B;HRG;SERPINB8;ANXA2
HemostasisF11R.2;BA1;BSG;SCG3;MAFGA;DGKG;STXBP3;SERPINF2B;CBX5
Platelet activation, signaling and aggregationTRPC6A;GAS6;CAP1;SRGN;ABHD12;CD9B;SPARC;WDR1;G6b
Platelet degranulationPLEK;SPARC;MMRN1;SRGN;F13A1A.1;AASS;WDR1;MMRN2A;GAS6
Response to elevated platelet cytosolic Ca2+CD9A;MMRN2A;BRPF3;WDR1;STXBP3;MMRN1;PLEK;SERPINF2B;CD9B

HRG has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity, heme binding, heparan sulfate proteoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HRG itself. We selected most functions HRG had, and list some proteins which have the same functions with HRG. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase inhibitor activityCSTA;LCN1;BIRC5B;CST11;CST9L;SERPINB13;CARD16;CST4;NLRC4
heme bindingCYP1C2;HBAE1;NOX4;CYB5A;IDO2;CYP2C19;CYCS;HRG;CYP8B1
heparan sulfate proteoglycan bindingGPC1;SLIT2;GPC4;GPC1B;PLA2G2D;Gpc2;GPC6A;GPC3;SEMA5A
heparin bindingRSPO1;LRPAP1;FGF14;LIPG;SERPIND1;CCL7;CCL23;VEGFAB;MSTN
immunoglobulin bindingcgr2b;VWF;HRG
metal ion bindingFGD4A;ZNF501;HAGHL;CRBN;IMPDH1;SNAI1;PLA2G2F;ITGAL;KAT6A
protein bindingTRDN;PHF16;PEX5;LRSAM1;SEC24D;TSC22D1;WFDC9;TMPRSS4;MAPKBP1
receptor bindingRARA;SEMA4D;SRI;DPP4;NPPA;ACOT8;TGFB2;PGR;PDGFRB
serine-type endopeptidase inhibitor activitySERPINA6;CCNH;WFIKKN2;SERPINA3;SERPINA3K;SPINT1;SERPINB1L4;WFDC6A;AGT
zinc ion bindingSHARPIN;DTX2;RNF181;SHRPRBCK1R;RXRGB;PDLIM3A;CPB2;NEIL3;ZDHHC11

HRG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HRG here. Most of them are supplied by our site. Hope this information will be useful for your research of HRG.

q99xu0_strp1; RCHY1; q99xu0_strp1; PLSCR1; GAMMAHV.ORF4; GAMMAHV.ORF31; SPRY1; FN1; TNFRSF1A; q99ib8-pro_0000045596; CHRD; RABAC1; d-mannose

Hu, S; Dai, HB; et al. Silencing EGFR/HER3 signaling with a novel anti-EGFR domain II/IV antibody. CANCER LETTERS 357:374-383(2015).
Kawakami, H; Okamoto, I; et al. The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells. ONCOTARGET 5:11847-11856(2014).
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