Recombinant Human HRG Protein, GST-tagged

• Cat.No.: HRG-5032H
• Product Overview: Human HRG full-length ORF ( NP_000403.1, 1 a.a. - 525 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the proteins effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 86 kDa
• AA Sequence: MKALIAALLLITLQYSCAVSPTDCS AVEPEAEKALDLINKRRRDGYLFQL LRIADAHLDRVENTTVYYLVLDVQE SDCSVLSRKYWNDCEPPDSRRPSEI VIGQCKVIATRHSHESQDLRVIDFN CTTSSVSSALANTKDSPVLIDFFED TERYRKQANKALEKYKEENDDFASF RVDRIERVARVRGGEGTGYFVDFSV RNCPRHHFPRHPNVFGFCRADLFYD VEALDLESPKNLVINCEVFDPQEHE NINGVPPHLGHPFHWGGHERSSTTK PPFKPHGSRDHHHPHKPHEHGPPPP PDERDHSHGPPLPQGPPPLLPMSCS SCQHATFGTNGAQRHSHNNNSSDLH PHKHHSHEQHPHGHHPHAHHPHEHD THRQHPHGHHPHGHHPHGHHPHGHH PHGHHPHCHDFQDYGPCDPPPHNQG HCCHGHGPPPGHLRRRGPGKGPRPF HCRQIGSVYRLPPLRKGEVLPLPEA NFPSFPLPHHKHPLKPDNQPFPQSV SESCPGKFKSGFPQVSMFFTHTFPK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: HRG histidine-rich glycoprotein [ Homo sapiens ]
• Official Symbol: HRG
• Synonyms: HRG; histidine-rich glycoprotein; histidine proline rich glycoprotein; HPRG; HRGP; thrombophilia due to elevated HRG; histidine-proline-rich glycoprotein; THPH11; DKFZp779H1622
• Gene ID: 3273
• mRNA Refseq: NM_000412
• Protein Refseq: NP_000403
• MIM: 142640
• UniProt ID: P04196