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HSBP1

  • Official Full Name

    heat shock factor binding protein 1

  • Overview

    The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes.Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response.During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interactswith the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.
  • Synonyms

    HSBP1; heat shock factor binding protein 1; heat shock factor-binding protein 1; HSBP1_HUMAN; HSF1BP; Nasopharyngeal carcinoma associated antigen 13; Nasopharyngeal carcinoma-associated antigen 13; NPC A 13; NPC-A-13; NPCA 13;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSBP1-5058H Recombinant Human HSBP1 Protein, GST-tagged Wheat Germ GST
Human HSBP1-311H Recombinant Human Heat Shock Factor Binding Protein 1 E.coli N/A
Human HSBP1-28195TH Recombinant Human HSBP1 E.coli N/A
Human HSBP1-28197TH Recombinant Human HSBP1 E.coli N/A
Human HSBP1-13949H Recombinant Human HSBP1, GST-tagged E.coli GST 1-76a.a.
Human HSBP1-2132H Recombinant Human HSBP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HSBP1-5141H Recombinant Human HSBP1 protein, GST-tagged E.coli GST 1-75aa
Human HSBP1-824H Recombinant Human HSBP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HSBP1-3704HF Recombinant Full Length Human HSBP1 Protein, GST-tagged In Vitro Cell Free System GST 76 amino acids
Mouse HSBP1-7866M Recombinant Mouse HSBP1 Protein Mammalian Cell His
Mouse Hsbp1-3440M Recombinant Mouse Hsbp1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HSBP1-4327M Recombinant Mouse HSBP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HSBP1-4327M-B Recombinant Mouse HSBP1 Protein Pre-coupled Magnetic Beads HEK293
Rat HSBP1-2918R Recombinant Rat HSBP1 Protein Mammalian Cell His
Rat HSBP1-2573R-B Recombinant Rat HSBP1 Protein Pre-coupled Magnetic Beads HEK293
Rat HSBP1-2573R Recombinant Rat HSBP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HSBP1-2149R Recombinant Rhesus monkey HSBP1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HSBP1-1970R-B Recombinant Rhesus Macaque HSBP1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HSBP1-1970R Recombinant Rhesus Macaque HSBP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken HSBP1-3795C Recombinant Chicken HSBP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSBP1 Related Articles

HSBP1 involved in several pathways and played different roles in them. We selected most pathways HSBP1 participated on our site, such as Attenuation phase, Cellular response to heat stress, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Attenuation phaseHSBP1B;CREBBP;HSBP1;PTGES3;HSBP1A
Cellular response to heat stressEEF1A1;HSPA14;PTGES3;HSPH1;HSBP1A;RPS19BP1;ST13;NUP50;C11orf73
Cellular responses to stressTERF2;PTGES3;RNF2;POT1A;HSBP1A;WIPI1;H3F3D;TXN;HIST1H1A
HSF1 activationEEF1A1;HSBP1;PTGES3
HSF1-dependent transactivationPTGES3;HSBP1;HSBP1A;HSBP1B

HSBP1 has several biochemical functions, for example, protein binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSBP1 itself. We selected most functions HSBP1 had, and list some proteins which have the same functions with HSBP1. You can find most of the proteins on our site.

Function Related Protein
protein bindingSFPI1;NDUFB11;CLPB;PPP3CB;LZTS1;SUZ12;HSPA1B;NCOR2;GMPPB
transcription corepressor activityZBTB32;KDM5B;DNMT3B;LMCD1;MAP3K10;CRYM;WNT4;TRIM28;AEBP1

HSBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSBP1.

CCDC53; SDCBP; KRTAP10-7; KIAA1217

Nagashima, Y; Iwata, Y; et al. Exogenous Salicylic Acid Activates Two Signaling Arms of the Unfolded Protein Response in Arabidopsis. PLANT AND CELL PHYSIOLOGY 55:1772-1778(2014).
Lewis, DJM; Wang, YF; et al. Effect of Vaginal Immunization with HIVgp140 and HSP70 on HIV-1 Replication and Innate and T Cell Adaptive Immunity in Women. JOURNAL OF VIROLOGY 88:11648-11657(2014).
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