HSPA1A
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Official Full Name
heat shock 70kDa protein 1A
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Overview
HSPA1A, a stress response protein belongs to the HSP70 family. In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. -
Synonyms
Heat Shock 70 kD Protein 1A; HSP70-1; HSPA1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Human
- Mouse
- Pongo abelii (Sumatran orangutan)
- Rat
- Sumatran orangutan
- E. coli
- E. coli.
- E.coli
- HEK293
- HEK293T
- Insect cell
- Insect Cell
- Insect Cells
- Mammalian cells
- Sf9 Insect Cell
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Strep
- Myc
- DDK
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- HSPA1A Related Articles
HSPA1A involved in several pathways and played different roles in them. We selected most pathways HSPA1A participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Spliceosome | SRSF9;SRSF2A;SYF2;SNRPD3L;SFRS3B;HSP70;RP9;SNW1;RBM17 |
MAPK signaling pathway | FGF13B;LRRK2;TAOK2;CD14;IL1B;RPS6KA4;GADD45AA;RPS6KA5;TNFRSF1A |
Protein processing in endoplasmic reticulum | DNAJB2;HSPH1;ERO1L;ATF6;LMAN1L;UFD1L;CAPN1A;NGLY1;P4HB |
Endocytosis | STAM2;HSP70L;ACAP2;SPG20A;SH3GL3B;PIP5K1AB;ERBB4A;CHMP2B;SH3GLB1 |
Antigen processing and presentation | HLA-DQA1;HSPA5;HLA-DMA;H2-AB1;TAP1;HLA-DPA1;HLA-B;CD4;HLA-DMB |
Estrogen signaling pathway | ESR2;PIK3CD;HSP90AA1;PIK3R3;ATF6B;SRC;KCNJ3;HSPA1B;CALML5 |
Prion diseases | MAP2K2;STIP1;CASP12;C1QB;NOTCH1;PRKACA;C1QC;Hc;LAMC1 |
Legionellosis | IL1B;NAIP6;IL12A;CYCS;HSPA6;MYD88;NAIP7;CASP8;HSPA8 |
Toxoplasmosis | SOCS1;LAMB4;STAT3;MAPK13;IRAK4;TGFB3;GNAI2;BCL2;IL12B |
Measles | IFNA17;SH2D1A;IFIH1;PIK3R1;NFKB1;HSPA6;AKT2;RAB9B;PIK3R5 |
Influenza A | SLC25A6;MYD88;IFNAR2;HLA-DMA;MAPK13;LOC100686744;AGFG1;OAS1B;MAP2K6 |
Epstein-Barr virus infection | YWHAG;PSMD7;TBPL1;YWHAH;SPN;POLR1C;GTF2B;NUP214;ICAM1 |
HSPA1A has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA1A itself. We selected most functions HSPA1A had, and list some proteins which have the same functions with HSPA1A. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | MAPK6;DNAH5;MYO15;ENTPD3;ABCC12;MAP3K1;NIM1K;STK24A;FYNA |
ATPase activity | ASNA1;ATP13A;INO80;ABCC1;DYNC2H1;KIF22;MYH8;KIF12;KIF7 |
ATPase activity, coupled | HSP104;VPS4B;ABCB1A;HSPA6;HSPA1A;VPS4A;MYO1E;MYH3;CCT8 |
C3HC4-type RING finger domain binding | DNAJA1;HSPA1A;KCNH2;HSPA1B;HSPA8;PINK1 |
G-protein coupled receptor binding | RSPO3;PROK2;GNAI2B;GNAT2;PARK2;QRFP;GHRL;UCN3L;USP20 |
enzyme binding | KIAA1967;HIF1A;EGLN1;JUND;HDAC1;PTPN1;HINFP;SLPI;CASP2 |
heat shock protein binding | NFKB1;PARK2;LIMK1;HSPA1A;APAF1;DAXX;DLST;CDC37;CDC37L1 |
protein binding | MSN;UBE2R2;SEPT10;RUNX2;PWWP2B;BRE;CDC42EP4;MCC;TRAPPC6A |
protein binding involved in protein folding | PFDN2;HSPA1B;CALR;CD74;PFDN1;PDCL3;DNAJB8;CALR3;HSPA1A |
receptor binding | PVRL2;INHA;FASLG;SRMS;AMH;NUDT7;AMN;PLA2G1B;GFRA3 |
ubiquitin protein ligase binding | PRKAR2A;UBE2NB;UBXN6;WASH;CKB;USP13;HSPD1;CUL3B;CCDC50 |
unfolded protein binding | HSPA2;PPIA;CCT6A;DNAJA3B;TRAP1;NDUFAF1;GRXCR2;PFDN6;AIP |
virus receptor activity | HLA-DRB1;TNFRSF14;ACE2;ITGA2;CR1;CD4;CLEC4G;SLC52A2;TNFRSF4 |
HSPA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA1A.
EGFR; STUB1; SNCA; HSP90AA1
- Q&As
- Reviews
Q&As (6)
Ask a questionHSPA1A has multiple associations with other proteins and diseases. For example, it may interact with the p53 protein to affect the occurrence and progression of tumors, and may also be associated with neurodegenerative diseases and be involved in the pathogenesis of diseases such as Alzheimer's disease.
HSPA1A can protect cells from damage through synergistic effects with other molecular chaperones such as HSP70 and HSP40 under stressful conditions. In addition, it can also be involved in the regulation of apoptosis.
Yes, HSPA1A has therapeutic potential. In tumor therapy, drug suppression or gene therapy against HSPA1A may become a new way to treat tumors. At the same time, inhibitors against HSPA1A are also being developed.
Aberrant expression of HSPA1A may be associated with a variety of diseases, especially cancer, neurodegenerative diseases, etc. For example, in tumors such as lung, breast, and colon cancer, HSPA1A expression levels may be abnormally elevated.
Levels of HSPA1A can be detected by methods such as immunohistochemistry, western blotting, and real-time PCR, which can assess the amount of HSPA1A in tissues and cells.
This protein can bind to unfolded proteins to form multimeric complexes that facilitate proper folding and transport of proteins. In addition, it can also work synergistically with other molecular chaperones such as HSP70 and HSP40 to participate in the correct folding and transport of proteins.
Customer Reviews (3)
Write a reviewUsing HSPA1A experiments can obtain consistent results and reduce the uncertainty of experiments.
HSPA1A has good stability and is suitable for long-term storage and use.
HSPA1A can effectively simulate the function of the target protein in vitro.
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