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HSPA1A

  • Official Full Name

    heat shock 70kDa protein 1A

  • Overview

    HSPA1A, a stress response protein belongs to the HSP70 family. In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
  • Synonyms

    Heat Shock 70 kD Protein 1A; HSP70-1; HSPA1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Human
  • Mouse
  • Pongo abelii (Sumatran orangutan)
  • Rat
  • Sumatran orangutan
  • E. coli
  • E. coli.
  • E.coli
  • HEK293
  • HEK293T
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Mammalian cells
  • Sf9 Insect Cell
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Strep
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSPA1A-266H Active Recombinant Human HSPA1A E.coli N/A
Human HSPA1A-321H Recombinant Human Heat Shock 70 kDa Protein 1A E.coli His
Human HSPA1A-4850H Recombinant Human heat shock 70kDa protein 1A, GST-tagged E.coli GST
Human HSPA1A-1854H Recombinant Human HSPA1A, His-tagged E.coli His
Human HSPA1A-4851H Recombinant Human heat shock 70kDa protein 1A, His-tagged Sf9 Insect Cell His
Human HSPA1A-526H Recombinant Human HSPA1A protein, His-tagged E.coli His
Human HSPA1A-6950H Active Recombinant Human HSPA1A protein, His-tagged Insect Cells His Ala2-Asp641
Human HSPA1A-519HCL Recombinant Human HSPA1A cell lysate Insect Cell N/A
Human HSPA1A-0701H Recombinant Human HSPA1A Protein (M1-D641), Tag Free Insect Cell No tag M1-D641
Human HSPA1A-012H Active Recombinant Human HSPA1A Protein, His-tagged Insect Cell His 2-641
Human HSPA1A-116HFL Active Recombinant Full Length Human HSPA1A Protein, C-Flag-tagged Mammalian cells Flag
Human HSPA1A-426H Recombinant Human HSP70 Protein, His-tagged HEK293 His Ala2-Asp641
Human HSPA1A-2198H Recombinant Human HSPA1A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HSPA1A-0702H Recombinant Human HSPA1A Protein (M1-D641), His/Strep tagged Insect Cell His/Strep M1-D641
Human HSPA1A-1117H Recombinant Human HSPA1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HSPA1A-3358H Recombinant Human HSPA1A Protein (Met1-Asp641), C-His tagged E.coli C-His Met1-Asp641
Human HSPA1A-015H Active Recombinant Human HSPA1A Protein, His-tagged E.coli His 2-641
Human HSPA1A-1117H-B Recombinant Human HSPA1A Protein Pre-coupled Magnetic Beads HEK293
Human HSPA1A-1243H Recombinant Human HSPA1A protein, His-tagged HEK293 His Ala2-Asp641
Human HSPA1A-066H Active Recombinant Human HSPA1A Protein, His-tagged Insect cell His 2-641
Human HSPA1A-067H Active Recombinant Human HSPA1A Protein, His-tagged E. coli His 2-641
Mouse Hspa1a-1482M Recombinant Mouse Hspa1a protein, His-tagged E.coli His Met1~Asp641
Mouse Hspa1a-1306M Recombinant Mouse Hspa1a protein, His-tagged HEK293 His Ala2-Asp641
Mouse Hspa1a-3452M Recombinant Mouse Hspa1a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat HSPA1A-2944R Recombinant Rat HSPA1A protein, His-tagged HEK293 His Ala2-Asp641
Rat Hspa1a-1638R Recombinant Rat Hspa1a Protein, His-tagged E.coli N-His Met1-Asp641
Rat HSPA1A-2599R Recombinant Rat HSPA1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Hspa1-001R Recombinant Rat Hspa1a/Hspa1b Protein E. coli. N/A
Rat HSPA1A-2599R-B Recombinant Rat HSPA1A Protein Pre-coupled Magnetic Beads HEK293
Cattle HSPA1A-1481C Recombinant Cattle HSPA1A protein, His-tagged E.coli His Met1~Asp641 (Accession # Q27975)
Pongo abelii (Sumatran orangutan) HSPA1A-5400P Recombinant Sumatran orangutan HSPA1A (Met1-Glu386, A148G, R155G, R171A, I173A, N174A) Protein, C-His tagged E.coli C-His Met1-Glu386, A148G, R155G, R171A, I173A, N174A
Pongo abelii (Sumatran orangutan) HSPA1A-5401P Recombinant Sumatran orangutan HSPA1A (Met1-Glu386, R72A, V82A, Y149A, D206A, T226A) Protein, C-His tagged E.coli C-His Met1-Glu386, R72A, V82A, Y149A, D206A, T226A
Pongo abelii (Sumatran orangutan) HSPA1A-5402P Recombinant Sumatran orangutan HSPA1A (Met1-Glu386, V59A, D69A, H89A, E231A, R261A) Protein, C-His tagged E.coli C-His Met1-Glu386, V59A, D69A, H89A, E231A, R261A
Pongo abelii (Sumatran orangutan) HSPA1A-5403P Recombinant Sumatran orangutan HSPA1A (Met1-Glu386, Y149A, G224A, D225A, T226A, E315A) Protein, C-His tagged E.coli C-His Met1-Glu386, Y149A, G224A, D225A, T226A, E315A
Sumatran orangutan HSPA1A-5404S Recombinant Sumatran orangutan HSPA1A Protein (Met1-Glu386), N-His tagged E.coli N-His Met1-Glu386
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSPA1A Related Articles

HSPA1A involved in several pathways and played different roles in them. We selected most pathways HSPA1A participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SpliceosomeSRSF9;SRSF2A;SYF2;SNRPD3L;SFRS3B;HSP70;RP9;SNW1;RBM17
MAPK signaling pathwayFGF13B;LRRK2;TAOK2;CD14;IL1B;RPS6KA4;GADD45AA;RPS6KA5;TNFRSF1A
Protein processing in endoplasmic reticulumDNAJB2;HSPH1;ERO1L;ATF6;LMAN1L;UFD1L;CAPN1A;NGLY1;P4HB
EndocytosisSTAM2;HSP70L;ACAP2;SPG20A;SH3GL3B;PIP5K1AB;ERBB4A;CHMP2B;SH3GLB1
Antigen processing and presentationHLA-DQA1;HSPA5;HLA-DMA;H2-AB1;TAP1;HLA-DPA1;HLA-B;CD4;HLA-DMB
Estrogen signaling pathwayESR2;PIK3CD;HSP90AA1;PIK3R3;ATF6B;SRC;KCNJ3;HSPA1B;CALML5
Prion diseasesMAP2K2;STIP1;CASP12;C1QB;NOTCH1;PRKACA;C1QC;Hc;LAMC1
LegionellosisIL1B;NAIP6;IL12A;CYCS;HSPA6;MYD88;NAIP7;CASP8;HSPA8
ToxoplasmosisSOCS1;LAMB4;STAT3;MAPK13;IRAK4;TGFB3;GNAI2;BCL2;IL12B
MeaslesIFNA17;SH2D1A;IFIH1;PIK3R1;NFKB1;HSPA6;AKT2;RAB9B;PIK3R5
Influenza ASLC25A6;MYD88;IFNAR2;HLA-DMA;MAPK13;LOC100686744;AGFG1;OAS1B;MAP2K6
Epstein-Barr virus infectionYWHAG;PSMD7;TBPL1;YWHAH;SPN;POLR1C;GTF2B;NUP214;ICAM1

HSPA1A has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA1A itself. We selected most functions HSPA1A had, and list some proteins which have the same functions with HSPA1A. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAPK6;DNAH5;MYO15;ENTPD3;ABCC12;MAP3K1;NIM1K;STK24A;FYNA
ATPase activityASNA1;ATP13A;INO80;ABCC1;DYNC2H1;KIF22;MYH8;KIF12;KIF7
ATPase activity, coupledHSP104;VPS4B;ABCB1A;HSPA6;HSPA1A;VPS4A;MYO1E;MYH3;CCT8
C3HC4-type RING finger domain bindingDNAJA1;HSPA1A;KCNH2;HSPA1B;HSPA8;PINK1
G-protein coupled receptor bindingRSPO3;PROK2;GNAI2B;GNAT2;PARK2;QRFP;GHRL;UCN3L;USP20
enzyme bindingKIAA1967;HIF1A;EGLN1;JUND;HDAC1;PTPN1;HINFP;SLPI;CASP2
heat shock protein bindingNFKB1;PARK2;LIMK1;HSPA1A;APAF1;DAXX;DLST;CDC37;CDC37L1
protein bindingMSN;UBE2R2;SEPT10;RUNX2;PWWP2B;BRE;CDC42EP4;MCC;TRAPPC6A
protein binding involved in protein foldingPFDN2;HSPA1B;CALR;CD74;PFDN1;PDCL3;DNAJB8;CALR3;HSPA1A
receptor bindingPVRL2;INHA;FASLG;SRMS;AMH;NUDT7;AMN;PLA2G1B;GFRA3
ubiquitin protein ligase bindingPRKAR2A;UBE2NB;UBXN6;WASH;CKB;USP13;HSPD1;CUL3B;CCDC50
unfolded protein bindingHSPA2;PPIA;CCT6A;DNAJA3B;TRAP1;NDUFAF1;GRXCR2;PFDN6;AIP
virus receptor activityHLA-DRB1;TNFRSF14;ACE2;ITGA2;CR1;CD4;CLEC4G;SLC52A2;TNFRSF4

HSPA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA1A.

EGFR; STUB1; SNCA; HSP90AA1

Castro, GN; Cayado-Gutierrez, N; et al. Effects of temozolomide (TMZ) on the expression and interaction of heat shock proteins (HSPs) and DNA repair proteins in human malignant glioma cells. CELL STRESS & CHAPERONES 20:253-265(2015).
Ortner, V; Ludwig, A; et al. An artificial HSE promoter for efficient and selective detection of heat shock pathway activity. CELL STRESS & CHAPERONES 20:277-288(2015).
  • Q&As
  • Reviews

Q&As (6)

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How is HSPA1A associated with other proteins or diseases? 06/20/2022

HSPA1A has multiple associations with other proteins and diseases. For example, it may interact with the p53 protein to affect the occurrence and progression of tumors, and may also be associated with neurodegenerative diseases and be involved in the pathogenesis of diseases such as Alzheimer's disease.

What is the role of HSPA1A in stressful conditions? 05/24/2022

HSPA1A can protect cells from damage through synergistic effects with other molecular chaperones such as HSP70 and HSP40 under stressful conditions. In addition, it can also be involved in the regulation of apoptosis.

Does HSPA1A have therapeutic potential? 03/24/2022

Yes, HSPA1A has therapeutic potential. In tumor therapy, drug suppression or gene therapy against HSPA1A may become a new way to treat tumors. At the same time, inhibitors against HSPA1A are also being developed.

What are the health effects of aberrant expression of HSPA1A? 06/28/2021

Aberrant expression of HSPA1A may be associated with a variety of diseases, especially cancer, neurodegenerative diseases, etc. For example, in tumors such as lung, breast, and colon cancer, HSPA1A expression levels may be abnormally elevated.

How is the level of HSPA1A detected? 03/18/2020

Levels of HSPA1A can be detected by methods such as immunohistochemistry, western blotting, and real-time PCR, which can assess the amount of HSPA1A in tissues and cells.

How is HSPA1A involved in the proper folding and transport of proteins? 02/18/2020

This protein can bind to unfolded proteins to form multimeric complexes that facilitate proper folding and transport of proteins. In addition, it can also work synergistically with other molecular chaperones such as HSP70 and HSP40 to participate in the correct folding and transport of proteins.

Customer Reviews (3)

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Reviews
05/11/2022

    Using HSPA1A experiments can obtain consistent results and reduce the uncertainty of experiments.

    01/26/2022

      HSPA1A has good stability and is suitable for long-term storage and use.

      01/10/2021

        HSPA1A can effectively simulate the function of the target protein in vitro.

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