| Official Full Name | heat shock 70kDa protein 1A |
| Background | HSPA1A, a stress response protein belongs to the HSP70 family. In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. |
| Synonyms | Heat Shock 70 kD Protein 1A; HSP70-1; HSPA1 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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HSPA1A involved in several pathways and played different roles in them. We selected most pathways HSPA1A participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | PRPF40A; HNRNPM; SNRPB2; SRSF5; PCBP1; PRP19; TCERG1; DDX5; TCERG1A; HNRNPUB |
| MAPK signaling pathway | PPP3CA; TGFBR1; FGFR1A; MAP2K4; ARRB1; ATF4; MRAS; GADD45B; RAC1A; HRASA |
| Protein processing in endoplasmic reticulum | HYOU1; ATXN3; EDEM3; AMFR; SSR2; PLAA; DNAJA2; PRKCSH; RNF185; STT3B |
| Endocytosis | ARF6; SNX4; CLINT1A; ADRB1; WASL; PDGFRA; WIPF2; AMPH; PIP5K1AB; LDLRA |
| Antigen processing and presentation | KIR2DS5; KLRD1; KIR2DL1; HLA-DRB4; HSPA4; RFXAP; CD74; HLA-DQA2; HSPA6; KIR3DL2 |
| Estrogen signaling pathway | HSPA1A; ESR1; SOS1; ATF4; GPR30; GABBR2; ITPR3; KCNJ3; MAPK3; CREB5 |
| Prion diseases | MAP2K2; C5; C1QA; HSPA5; PRNP; C7; NCAM2; NOTCH1; C9; MAPK1 |
| Legionellosis | TNF; APAF1; RAB1B; HSPA8; Itgam&Itgb2; CASP1; CXCL3; ITGAM; TLR4; ITGB2L |
| Toxoplasmosis | RELA; MAPK1; NOS2; NFKB1; TGFB1; HSPA2; HSPA6; IRGM1; LAMB4; Casp3 |
| Measles | IL12B; IFNA4; RCHY1; PIK3R1; STAT1; OAS1B; IRAK4; TLR2; IKBKE; CD209A |
| Influenza A | IFNA2; DDX39B; TBK1; IFNA10; SOCS3; TNFRSF10B; IFNG; IL8L2; IFNA16; NFKBIA |
| Epstein-Barr virus infection | DDX58; AKAP8L; HSPB1; TRADD; MAPK13; NEDD4; YWHAE; XPO1; MAPK10; IL10RB |
HSPA1A has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA1A itself. We selected most functions HSPA1A had, and list some proteins which have the same functions with HSPA1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CSNK1D; DGKD; BBS10; DAPK1; KIAA1804; DGUOK; RFC5; PAPSS1; DDX39A; ERCC3 |
| ATPase activity | RNF213; PSMC3; OLA1; KIFC2; VPS4B; ABCC1; DYNC2H1; ERCC3; ATAD1B; KIF20B |
| ATPase activity, coupled | HSPA6; ABCB1A; HSPA1B; CCT8; VPS4A; MYH3; HSP104; NSF; HSPA8; VPS4B |
| C3HC4-type RING finger domain binding | HSPA1B; DNAJA1; HSPA8; KCNH2; HSPA1A; PINK1 |
| G-protein coupled receptor binding | RSPO2; PSAP; GNAI2; PPY; GNA15; GNA15.1; GNAI2B; PSAPL1; HSPA8; HSPA1B |
| enzyme binding | CA; CYP2C19; UGT1A6; CBS; PLSCR4; Ar; NOXO1; LAMB1; CAV1; GOLPH3 |
| heat shock protein binding | FAF1; DNAJB6; DNAJC7; FKBP4; DMPK; HSPA1A; SSUH2.2; APAF1; HSPA1L; DNAJA3 |
| protein binding | HHLA2; INTS3; USP12; CD2BP2; LCORL; GPR143; CD8B1; TRIM33; ITGA3; WWP1 |
| protein binding involved in protein folding | HSPA1B; PFDN1; HSPA1A; PDCL3; CALR3; CLGN; DNAJB8; CALR; RIC3; CD74 |
| receptor binding | MSTN; LTA; HRG; PLXNC1; PRDX5; SRMS; SSFA2; EFNA1; STOML2; TESPA1 |
| ubiquitin protein ligase binding | NGFR; SLC22A18; CUL5A; PINK1; UBE2NB; C10orf46; UBE2T; PARK2; RNF34; RIPK1 |
| unfolded protein binding | AFG3L2; PFDN1; PFDN6; LRPAP1; CALRL2; CHAF1A; HSPA1L; DNAJB11; RP2; AIPL1 |
| virus receptor activity | DPP4; PVRL4; NCAM1; HLA-DRB1; ITGAV; CCR5; HYAL2; SLC10A1; XPR1; HTR2A |
HSPA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA1A.
EGFR; STUB1; SNCA; HSP90AA1
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