hspa2
Share
  • Official Full Name
  • heat shock 70kDa protein 2
  • Background
  • Heat shock proteins (HSPs) are an important part of the cell's machinery for protein folding and help to protect cells from stress. HSPs are expressed in response to a wide variety of physiological and environmental insults including anticancer chemotherapy, thus allowing some cells to survive near lethal conditions. HSPs are expressed in tumor cell proliferation, differentiation, invasion and metastasis. In addition to improving overall protein integrity, HSP70 directly inhibits apoptosis, and has been shown to be involved in a protective role against thermal stress and cytotoxic drugs. Recently HSP70 has been reported as a prognostic marker in breast, prostate, lung and liver cancer patients
  • Synonyms
  • HSPA2; heat shock 70kDa protein 2; heat shock 70kD protein 2; heat shock-related 70 kDa protein 2; HSP70-2; HSP70-3
Cat.#:HSPA2-5105HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HSPA2 Protein, GST-tagged
+Inquiry
Cat.#:HSPA2-13986HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPA2, GST-tagged
+Inquiry
Cat.#:HSPA2-27082THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPA2
+Inquiry
Cat.#:HSPA2-8255HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPA2 protein, His-tagged
+Inquiry
Cat.#:HSPA2-7907MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HSPA2 Protein
+Inquiry
Cat.#:HSPA2-2946RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HSPA2 Protein
+Inquiry
Cat.#:Hspa2-8256RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hspa2 protein, His & S-tagged
+Inquiry
Cat.#:HSPA2-1728CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HSPA2
+Inquiry
Cat.#:HSPA2-5355HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HSPA2 293 Cell Lysate
+Inquiry

Involved Pathway

HSPA2 involved in several pathways and played different roles in them. We selected most pathways HSPA2 participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Spliceosome
NHP2L1; DHX38; U2AF1L4; SF3B2; SRSF6; HSPA6; SF3B14; NHP2L1B; SNRNP40; DHX16
MAPK signaling pathway
MKNK2B; GRB2; TGFB1; ATF4; MAP3K7; CASP3B; CACNA1BA; CDC42; CDC25B; PAK2A
Protein processing in endoplasmic reticulum
MAPK8A; RBX1; DNAJB1B; ATXN3L; HSPA1L; UBE2G1B; NFE2L2A; SEC31B; CRYAA; PARK2
Endocytosis
DNAJC6; RNF41; IGF1RA; GRK5; ARPC5B; RAB11FIP5; IST1; ADRB2B; CBL; ARAP1
Antigen processing and presentation
KIR2DS3; KIR2DS4; RFXANK; PSME1; HLA-DQB1; HSPA1L; HLA-DOB; NFYB; CD8A; CD74
Estrogen signaling pathway
NRAS; SP1; GPR30; HSPA2; CALM3; PLCB3; MAPK3; CALM1; GRM1; CREB3L2
Legionellosis
EEF1A1; RAB1B; NAIP7; CXCL1; Casp3; NAIP1; CASP1; CASP7; NLRC4; IL18
Toxoplasmosis
HLA-DOB; LDLR; IL10RA; HLA-DMA; GNAI3; MAPK9; TYK2; HLA-DPA1; HLA-DRB5; PIK3R5
Measles
PIK3CB; IFNB1; IRAK4; TACR1; Fasl; CLEC4M; CBLB; HSPA1L; IFNA4; IL2RB
Influenza A
PYCARD; HLA-DRB1; HLA-DOA; CXCL8; TLR4; HLA-DQA1; H2-AB1; PIK3CD; MAPK13; TNF
Epstein-Barr virus infection
PSMD11; PSMD12; ENTPD3; MAPK11; HSPB2; GTF2E1; MAPK8; PIK3R2; H2-Q10; IKBKB

Protein Function

HSPA2 has several biochemical functions, for example, ATP binding, enzyme binding, glycolipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA2 itself. We selected most functions HSPA2 had, and list some proteins which have the same functions with HSPA2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SMC5; PRKX; PIP5K1A; ABCA4A; ATP1A1B; NVL; PIK3CG; CDC6; HELB; RFK
Function enzyme binding
Related Protein POR; MAPK14; PARP1; TSPAN15; NR5A1; MSH3; ERN1; BACE1; PDCD2; NCOA1
Function glycolipid binding
Related Protein PLEKHA8; PLEKHA8P1; PRRC2B; HSPA2; CPTP; GLTP; CD1C; CLEC4F; GLTPD1; GLTPD2
Function protein binding
Related Protein NR0B2; BMP1A; VENTX; BATF2; ZFP346; RAB24; EPHB1; SMAD4; NCOR2; LEPROT
Function unfolded protein binding
Related Protein TCP1; HSP90AB1; CLGN; LMAN1; DNAJB5; AHSP; AIPL1; PTGES3; DNAJB11; HSPA5

Interacting Protein

HSPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA2.
HSPBP1; TRIM38; BAG4; q96be0_human; RIPK2; PPP1CC; HSF2; PSMD2; q53fc7_human; UNC45B; HSPH1

HSPA2 Related Articles

Sun, J; Wang, J; et al. Knockdown of Polycomb-Group RING Finger 6 Modulates Mouse Male Germ Cell Differentiation in Vitro. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 35:339-352(2015).
Motiei, M; Tavalaee, M; et al. Evaluation of HSPA2 in fertile and infertile individuals. ANDROLOGIA 45:66-72(2013).