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HSPA2

  • Official Full Name

    heat shock 70kDa protein 2

  • Overview

    Heat shock proteins (HSPs) are an important part of the cell's machinery for protein folding and help to protect cells from stress. HSPs are expressed in response to a wide variety of physiological and environmental insults including anticancer chemotherapy, thus allowing some cells to survive near lethal conditions. HSPs are expressed in tumor cell proliferation, differentiation, invasion and metastasis. In addition to improving overall protein integrity, HSP70 directly inhibits apoptosis, and has been shown to be involved in a protective role against thermal stress and cytotoxic drugs. Recently HSP70 has been reported as a prognostic marker in breast, prostate, lung and liver cancer patients
  • Synonyms

    HSPA2; heat shock 70kDa protein 2; heat shock 70kD protein 2; heat shock-related 70 kDa protein 2; HSP70-2; HSP70-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|S
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSPA2-5105H Recombinant Human HSPA2 Protein, GST-tagged Wheat Germ GST
Human HSPA2-8255H Recombinant Human HSPA2 protein, His-tagged E.coli His Lys529~Gln615 (Accession # P54652)
Human HSPA2-27082TH Recombinant Human HSPA2 E.coli N/A
Human HSPA2-13986H Recombinant Human HSPA2, GST-tagged E.coli GST C-term-350a.a.
Human HSPA2-5355HCL Recombinant Human HSPA2 293 Cell Lysate HEK293 N/A
Human HSPA2-6536H Recombinant Human HSPA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HSPA2-001H Recombinant Human HSPA2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human HSPA2-3817HF Recombinant Full Length Human HSPA2 Protein, GST-tagged In Vitro Cell Free System GST 639 amino acids
Human HSPA2-3607H Recombinant Human HSPA2 Protein (Ser2-Glu98), N-His tagged E.coli N-His Ser2-Glu98
Human HSPA2-1605HFL Recombinant Full Length Human HSPA2 Protein, C-Flag-tagged Mammalian cells Flag
Human HSPA2-1118H Recombinant Human HSPA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HSPA2-0699H Recombinant Human HSPA2 Protein (S2-D639), Tag Free E.coli No tag S2-D639
Human HSPA2-0700H Recombinant Human HSPA2 Protein (S2-D639), His tagged E.coli His S2-D639
Human HSPA2-1118H-B Recombinant Human HSPA2 Protein Pre-coupled Magnetic Beads HEK293
Mouse HSPA2-7907M Recombinant Mouse HSPA2 Protein Mammalian Cell His
Mouse HSPA2-4356M-B Recombinant Mouse HSPA2 Protein Pre-coupled Magnetic Beads HEK293
Mouse HSPA2-4356M Recombinant Mouse HSPA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hspa2-1188M Recombinant Mouse Hspa2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat HSPA2-2946R Recombinant Rat HSPA2 Protein Mammalian Cell His
Rat Hspa2-8256R Recombinant Rat Hspa2 protein, His & S-tagged E.coli His/S Leu23~Ile314
Rat HSPA2-2601R Recombinant Rat HSPA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HSPA2-2601R-B Recombinant Rat HSPA2 Protein Pre-coupled Magnetic Beads HEK293
Chicken HSPA2-1728C Recombinant Chicken HSPA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSPA2 Related Articles

HSPA2 involved in several pathways and played different roles in them. We selected most pathways HSPA2 participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SpliceosomeSRSF5;DDX39B;CRNKL1;HSPA8;LSM4;U2AF2B;PCBP1;HNRPK;SNRPB2
MAPK signaling pathwaySTK3;FASLG;HSC70;FGF4;NFKB1;DUSP3;TRAF6;FGF7;MAP3K1
Protein processing in endoplasmic reticulumERP29;SEC62;YOD1;DNAJB2;TRAM1;EIF2AK3;CKAP4;NFE2L2A;WFS1
EndocytosisHSPA1A;IGF1R;ARRB1;SH3GLB2B;ZFYVE16;ARRB2A;ZFP652;SRC;SNX2
Antigen processing and presentationKIR2DL1;PSME1;RFX5;HSPA4;HLA-DOB;HLA-DQB1;KLRC1;HLA-C;RFXANK
Estrogen signaling pathwayHSPA1L;PIK3R3;GABBR2;ESR1;FKBP5;CREB3L3;CALM3;GNAI1;PIK3CA
LegionellosisNLRC4;CD14;CXCL2;NFKBIA;CXCL1;MYD88;Casp3;TLR2;NAIP1
ToxoplasmosisHLA-DOA;HSPA6;HSPA1B;Toxoplasma Gondii Dense Granule Protein 7;TLR4;IRGM1;ITGA6;HLA-DPB1;CD40LG
MeaslesIFNA5;IFNA14;TLR2;CD209B;FCGR2B;HSPA1A;DOK1;Cd209g;OAS1B
Influenza AAGFG1;IFNAR1;TLR4;OAS3;MAPK13;PRSS3;OAS1A;DNAJB1;PRSS2
Epstein-Barr virus infectionXPO1;RB1;GTF2E1;POLR1D;MAP3K7;POLR2G;RIPK1;MAP2K7;HLA-DRB5

HSPA2 has several biochemical functions, for example, ATP binding, enzyme binding, glycolipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA2 itself. We selected most functions HSPA2 had, and list some proteins which have the same functions with HSPA2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP6V1BA;HSPA8;PMELA;ABCA4;SMOK2B;MAPK6;ADCY1;AK2;P2RX5
enzyme bindingNOTCH1;POLB;DYM;PYCARD;PPP1R3B;HIST1H2AL;MAPK14;HIST1H2AG;HSPA5
glycolipid bindingPRRC2B;GLTPD2;PLEKHA8;CPTP;CD1C;GLTPD1;GLTP;PLEKHA8P1;HSPA2
protein bindingAPBB1IP;RGS2;RGS14;ZCCHC11;SPATA8;LIN28A;IL10RB;TDRD1;Unc5b
unfolded protein bindingHSP90AA1;AFG3L2;HSP90AA1.1;CHAF1A;HSPA6;CALR3B;NDUFAF1;AIP;HSP26

HSPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA2.

HSPBP1; TRIM38; BAG4; q96be0_human; RIPK2; PPP1CC; HSF2; PSMD2; q53fc7_human; UNC45B; HSPH1

Sun, J; Wang, J; et al. Knockdown of Polycomb-Group RING Finger 6 Modulates Mouse Male Germ Cell Differentiation in Vitro. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 35:339-352(2015).
Motiei, M; Tavalaee, M; et al. Evaluation of HSPA2 in fertile and infertile individuals. ANDROLOGIA 45:66-72(2013).
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