inpp5k
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  • Official Full Name
  • inositol polyphosphate-5-phosphatase K
  • Background
  • This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • INPP5K; inositol polyphosphate-5-phosphatase K; inositol polyphosphate 5-phosphatase K; skeletal muscle and kidney enriched inositol phosphatase; SKIP; 43 kDa form skeletal muscle and kidney enriched inositol phosphatase; INP5K_HUMAN; muscle and kidney-enriched inositol phosphatase; PPS; Skeletal muscle and kidney-enriched inositol phosphatase
Cat.#:INPP5K-5104HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human INPP5K Protein, GST-tagged
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Cat.#:INPP5K-31407THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INPP5K, His-tagged
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Cat.#:INPP5K-2277RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey INPP5K Protein, His-tagged
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Cat.#:INPP5K-5448CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken INPP5K
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Cat.#:INPP5K-5196HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human INPP5K 293 Cell Lysate
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Cat.#:INPP5K-5197HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human INPP5K 293 Cell Lysate
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Involved Pathway

INPP5K involved in several pathways and played different roles in them. We selected most pathways INPP5K participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5K were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
MTMR2; PLCD3A; ITPKB; IMPA2; IMPAD1; MTMR1B; INPP4AB; ISYNA1; INPP5E; PLCD4
Metabolic pathways
ACY1; GPAA1; DAO.2; PLD1; ENO1B; IVD; CRYL1; LDHAL6B; MDH1AA; UGT8A
Phosphatidylinositol signaling system
MTMR8; PLCD1B; PPIP5K1; CDS2; PLCB3; INPP5J; MTMR1; PI4KAA; PIK3C2G; PRKCA
Insulin signaling pathway
BRAF; TRIP10A; G6PCA.1; PPP1CA; CALM1; PPP1CC; SOCS1; PRKAB1; RPTOR; EXOC7

Protein Function

INPP5K has several biochemical functions, for example, inositol bisphosphate phosphatase activity, inositol trisphosphate phosphatase activity, inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5K itself. We selected most functions INPP5K had, and list some proteins which have the same functions with INPP5K. You can find most of the proteins on our site.
Function
Related Protein
Function inositol bisphosphate phosphatase activity
Related Protein INPP5K; SGPP2; SACM1L; PTPRQ; PXYLP1; SACM1LB; TENC1; NT5DC3; CTDSPL2A; CTDSPL2B
Function inositol trisphosphate phosphatase activity
Related Protein INPP5K
Function inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
Related Protein INPP5A; INPP5J; INPP5K
Function inositol-1,4,5-trisphosphate 5-phosphatase activity
Related Protein INPP5K; INPP5J; INPP5B; INPP5A
Function inositol-polyphosphate 5-phosphatase activity
Related Protein INPP5A; INPP5J; INPPL1; INPP5D; INPP5K; INPP5E
Function lipid phosphatase activity
Related Protein PPAP2C; PTENB; PTENA; LPPR5B; INPP5K; EPHX2; PPAP2D; PPAP2CB; LPPR2A; PPAP2A
Function phosphatidylinositol phosphate 5-phosphatase activity
Related Protein SYNJ1; INPP5K
Function phosphatidylinositol trisphosphate phosphatase activity
Related Protein INPP5D; INPP4B; INPP5K
Function phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
Related Protein INPP5J; INPP5K
Function protein binding
Related Protein ACTG1; NLGN4X; P2RX4; UBB; HEMK1; OXA1L; ARR3; PDLIM3; a; PPP4C
Function vasopressin receptor activity
Related Protein OXTR; NPSR1; AVPR1A; INPP5K; AVPR1B; OXTRL; AVPR2; AVPR2L

Interacting Protein

INPP5K has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5K here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5K.
MAD2L1BP; KRT31; FATE1; LNX1; PYGM; EPPK1; DCD; PDXDC1; PFDN1; TTR; TK1; HSPB1