INPP5K
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Official Full Name
inositol polyphosphate-5-phosphatase K
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Overview
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
INPP5K; inositol polyphosphate-5-phosphatase K; inositol polyphosphate 5-phosphatase K; skeletal muscle and kidney enriched inositol phosphatase; SKIP; 43 kDa form skeletal muscle and kidney enriched inositol phosphatase; INP5K_HUMAN; muscle and kidney-enriched inositol phosphatase; PPS; Skeletal muscle and kidney-enriched inositol phosphatase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- INPP5K Related Signal Pathway
INPP5K involved in several pathways and played different roles in them. We selected most pathways INPP5K participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5K were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PLD4;IMPAD1;MTMR7B;PLCB3;PLCH1;MINPP1;PIK3CB;PLCB1;NUDT4A |
| Metabolic pathways | NME1;SYNJ1;CMAS;GSTZ1;ACSL1B;PTGS2;GLYCTK;DMGDH;CYP2B6 |
| Phosphatidylinositol signaling system | INPP5K;MTMR14;PRKCA;INPP5B;PIP4K2A;PPIP5K1;ITPK1A;PTENB;PIP5K2 |
| Insulin signaling pathway | G6PCA.1;GSK3AA;MAPK1;RPS6KB1B;RAF1B;MKNK1;SLC2A4;NRAS;CALM3A |
INPP5K has several biochemical functions, for example, inositol bisphosphate phosphatase activity, inositol trisphosphate phosphatase activity, inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5K itself. We selected most functions INPP5K had, and list some proteins which have the same functions with INPP5K. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol bisphosphate phosphatase activity | CTDSPL2A;TENC1;SACM1LA;PXYLP1;PTPRQ;INPP5K;CTDSPL2B;NT5DC3;SACM1LB |
| inositol trisphosphate phosphatase activity | |
| inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity | INPP5K;INPP5A;INPP5J |
| inositol-1,4,5-trisphosphate 5-phosphatase activity | INPP5B;INPP5K;INPP5J;INPP5A |
| inositol-polyphosphate 5-phosphatase activity | INPP5D;INPP5J;INPP5K;INPP5E;INPP5A;INPPL1 |
| lipid phosphatase activity | LPPR2A;LPPR5A;LPPR3A;PTENA;PPAP2A;EPHX2;PPAP2D;INPP5K;LPPR3 |
| phosphatidylinositol phosphate 5-phosphatase activity | SYNJ1;INPP5K |
| phosphatidylinositol trisphosphate phosphatase activity | INPP4B;INPP5K;INPP5D |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | INPP5J;INPP5K |
| protein binding | SLC25A23;YAF2;MAP3K7;CBLL1;ICA1;ZMAT2;COQ9;ARRB1;B2M |
INPP5K has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5K here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5K.
MAD2L1BP; KRT31; FATE1; LNX1; PYGM; EPPK1; DCD; PDXDC1; PFDN1; TTR; TK1; HSPB1
- Q&As
- Reviews
Q&As (7)
Ask a questionMutations in d-3-PHGDH have been associated with a neurological phenotype that overlaps with Marinesco-Sjögren syndrome and INPP5K disease.
l-serine administration is proposed as a promising therapeutic strategy for patients with d-3-PHGDH mutations.
This study reveals a common core phenotypical feature and a shared molecular mechanism among Marinesco-Sjögren syndrome, INPP5K disease, and d-3-PHGDH mutations.
Alterations in d-3-PHGDH, an enzyme that modulates the production of l-serine, were identified as a common molecular feature.
Six new INPP5K patients were included in this study.
The effect of l-serine was tested in zebrafish models with mutations in sil1, phgdh, and inpp5k a+b genes, which improved their neuronal phenotype.
INPP5K mutations are associated with a rare disorder that shares symptoms with Marinesco-Sjögren syndrome, such as cataracts, myopathy, and ataxia.
Customer Reviews (3)
Write a reviewWe observed minimal changes in results even after prolonged storage, showcasing its long-term stability.
Its reliability over time reduced the need for frequent reordering, saving both time and resources.
The absence of adverse effects on cells or organisms underscored the product's safety and suitability for biological research.
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