INSM2
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Official Full Name
insulinoma-associated 2
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Synonyms
INSM2; insulinoma-associated 2; insulinoma-associated protein 2; IA 6; mlt 1; zinc finger protein IA-6; insulinoma-associated protein IA-6; IA6; IA-6; mlt1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- INSM2 Related Articles
INSM2 involved in several pathways and played different roles in them. We selected most pathways INSM2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with INSM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
INSM2 has several biochemical functions, for example, DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSM2 itself. We selected most functions INSM2 had, and list some proteins which have the same functions with INSM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZBED4;YY1;HOXB6A;ZNF18;ZKSCAN6;SOX19A;PPARGC1A;PDS5B;TBX16 |
| metal ion binding | CXXC1A;SETDB1A;XRCC6BP1;MMP30;ATP13A3;ZNF763;PXDN;TET3;BCMO1 |
INSM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSM2.
- Q&As
- Reviews
Q&As (7)
Ask a questionKnocking down INSM2 inhibits fatty acid metabolism in neuroblastoma cells.
In neuroblastoma, the expression levels of INSM2 are significantly upregulated and are correlated with poor prognosis in patients.
INSM2 is regulated by super enhancers in neuroblastoma, and super enhancers control the expression of NB cell identity genes.
Abnormal lipid metabolism is a significant metabolic change in cancer, including neuroblastoma, where it plays a crucial role.
Mechanistically, INSM2 regulates the expression of SREBP1 by modulating the mTOR signaling pathway, influencing lipid metabolism and contributing to the occurrence and development of neuroblastoma.
INSM2's role in regulating lipid metabolism in neuroblastoma was discovered, indicating its improper control by super enhancers associated with NB cell identity genes.
INSM2 drives the growth of neuroblastoma cell lines, both in vitro and in vivo.
Customer Reviews (3)
Write a reviewClear and comprehensive training materials provided a solid foundation for understanding the product's application.
We appreciated the straightforward incorporation of the product into our laboratory's instrumentation and automation systems.
We appreciated the product's role in supporting open-access initiatives, promoting accessibility to scientific knowledge.
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