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Official Full Name importin 5
Background Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
Synonyms IPO5; importin 5; karyopherin (importin) beta 3 , KPNB3, RAN binding protein 5 , RANBP5; importin-5; IMB3; MGC2068; Pse1; karyopherin beta-3; RAN binding protein 5; ran-binding protein 5; importin beta-3 subunit; importin subunit beta-3; Ran_GTP binding
    • Species :
    • Human
    • Mouse
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IPO5-1467HCL Recombinant Human IPO5 cell lysate N/A
    Human IPO5-27548TH Recombinant Human IPO5 Wheat Germ N/A
    Mouse IPO5-8264M Recombinant Mouse IPO5 Protein Mammalian Cell His

    IPO5 involved in several pathways and played different roles in them. We selected most pathways IPO5 participated on our site, such as Disease, Infectious disease, Influenza Infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with IPO5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Infectious disease AP1M2; VPS37A; ANTXR1; CHMP4C; DOCK2; APOBEC3G; AP1S1; PDCD6IP; KPNA4; IPO5
    Influenza Infection KPNA4; CPSF4; IPO5; KPNA3; KPNA5
    Influenza Life Cycle IPO5
    Influenza Viral RNA Transcription and Replication IPO5
    vRNP Assembly IPO5

    IPO5 has several biochemical functions, for example, GTPase inhibitor activity, Ran GTPase binding, nuclear localization sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IPO5 itself. We selected most functions IPO5 had, and list some proteins which have the same functions with IPO5. You can find most of the proteins on our site.

    Function Related Protein
    GTPase inhibitor activity GPS1; ARL2; UBE4A; CPEB2; RHOH; SLIT2; RTKN; GPS2; CDC42SE1; TNK2
    Ran GTPase binding IPO4; TNPO2; XPOT; XPO6; TNPO1; DPY19L2; KPNB1; IPO13; XPO1; CSE1L
    nuclear localization sequence binding TNPO1; IPO13; NFKBIA; KPNA3; TNPO2; KPNA1; NUP214; IPO5; KPNB3; IPO4
    poly(A) RNA binding NSUN5; RPS24; NQO1; PPP1R2P9; LSM2; SLC25A5; TWF2; RRP9; NAT10; DIMT1L
    protein binding RIMS2; HNRNPH1; SIL1; INSIG1; ADORA1; ZIC3; HFE; ANKRD49; PFN1; TGFB3
    protein transporter activity RAP1A; KPNA2; XPO1; RAMP2; KPNB3; KPNA1; DSCR3; SNUPN; RANBP6; USO1

    IPO5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IPO5 here. Most of them are supplied by our site. Hope this information will be useful for your research of IPO5.

    RPL7; GABARAP; GABARAPL2; GABARAPL1; p27958-pro_0000037576

    Liang, HJ; Chai, RC; et al. Astrocytic Exportin-7 Responds to Ischemia Through Mediating LKB1 Translocation From the Nucleus to the Cytoplasm. JOURNAL OF NEUROSCIENCE RESEARCH 93:253-267(2015).
    Levin, A; Neufeldt, CJ; et al. Functional Characterization of Nuclear Localization and Export Signals in Hepatitis C Virus Proteins and Their Role in the Membranous Web. PLOS ONE 9:-(2014).

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