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IPO5

Official Full Name

importin 5
Overview

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
Synonyms

IPO5; importin 5; karyopherin (importin) beta 3 , KPNB3, RAN binding protein 5 , RANBP5; importin-5; IMB3; MGC2068; Pse1; karyopherin beta-3; RAN binding protein 5; ran-binding protein 5; importin beta-3 subunit; importin subunit beta-3; Ran_GTP binding;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IPO5-27548TH	Recombinant Human IPO5	Wheat Germ	N/A	100 amino acids	Inquiry
Human	IPO5-1467HCL	Recombinant Human IPO5 cell lysate		N/A		Inquiry
Human	IPO5-2335H	Recombinant Human IPO5 Protein, His-tagged	E.coli	N-His	Glu25-Cys247	Inquiry
Mouse	IPO5-8264M	Recombinant Mouse IPO5 Protein	Mammalian Cell	His		Inquiry
Mouse	IPO5-4581M-B	Recombinant Mouse IPO5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	IPO5-4581M	Recombinant Mouse IPO5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
IPO5 Related Articles

IPO5 involved in several pathways and played different roles in them. We selected most pathways IPO5 participated on our site, such as Disease, Infectious disease, Influenza Infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with IPO5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Disease	KPNA4;SYT2;CDC37;JAG2;GYG1;NUP35;PSTPIP2;AP1G1;PDCD6IP
Infectious disease	STX1B;VPS37A;SYT2;NMT2;KPNA3;CHMP4C;PACS1;CPSF4;AP1M2
Influenza Infection	KPNA4;CPSF4;KPNA5;IPO5;KPNA3
Influenza Life Cycle
Influenza Viral RNA Transcription and Replication
vRNP Assembly

IPO5 has several biochemical functions, for example, GTPase inhibitor activity, Ran GTPase binding, nuclear localization sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IPO5 itself. We selected most functions IPO5 had, and list some proteins which have the same functions with IPO5. You can find most of the proteins on our site.

Function	Related Protein
GTPase inhibitor activity	UBE4A;ARL2;TNK2;SLIT2;RTKN;CPEB2;CDC42SE1;PDE6D;RHOH
Ran GTPase binding	XPOT;DPY19L2;NUP153;RANBP3;RANBP10;IPO4;XPO6;IPO5;RANBP1
nuclear localization sequence binding	TNPO1;KPNA6;KPNB1;KPNA2;NFKBIA;TNPO2;KPNA1;KPNA3;KPNB3
poly(A) RNA binding	RPL26;UTP23;RPL18A;DHX16;SUMO1;PRPF40A;KIAA1324;TFB2M;RIMS2
protein binding	NUBP1;POLD1;ITGB3;HIST2H3C;CDCA5;RHEB;GRIP1;FKBP2;CWC15
protein transporter activity	RAMP3;TIMM9;RANBP6;L7RN6;RAMP2;AP2B1;VPS26BL;CHMP7;EIF4ENIF1

IPO5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IPO5 here. Most of them are supplied by our site. Hope this information will be useful for your research of IPO5.

RPL7; GABARAP; GABARAPL2; GABARAPL1; p27958-pro_0000037576

Liang, HJ; Chai, RC; et al. Astrocytic Exportin-7 Responds to Ischemia Through Mediating LKB1 Translocation From the Nucleus to the Cytoplasm. JOURNAL OF NEUROSCIENCE RESEARCH 93:253-267(2015).

Levin, A; Neufeldt, CJ; et al. Functional Characterization of Nuclear Localization and Export Signals in Hepatitis C Virus Proteins and Their Role in the Membranous Web. PLOS ONE 9:-(2014).