|Official Full Name||importin 5|
|Background||Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.|
|Synonyms||IPO5; importin 5; karyopherin (importin) beta 3 , KPNB3, RAN binding protein 5 , RANBP5; importin-5; IMB3; MGC2068; Pse1; karyopherin beta-3; RAN binding protein 5; ran-binding protein 5; importin beta-3 subunit; importin subunit beta-3; Ran_GTP binding|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
IPO5 involved in several pathways and played different roles in them. We selected most pathways IPO5 participated on our site, such as Disease, Infectious disease, Influenza Infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with IPO5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Disease||GCKR; JAG1; CUX1; RNF43; FDX1L; GPC6; OGN; AMN; CFTR; MMADHC|
|Infectious disease||AP1M2; VPS37A; ANTXR1; CHMP4C; DOCK2; APOBEC3G; AP1S1; PDCD6IP; KPNA4; IPO5|
|Influenza Infection||KPNA4; CPSF4; IPO5; KPNA3; KPNA5|
|Influenza Life Cycle||IPO5|
|Influenza Viral RNA Transcription and Replication||IPO5|
IPO5 has several biochemical functions, for example, GTPase inhibitor activity, Ran GTPase binding, nuclear localization sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IPO5 itself. We selected most functions IPO5 had, and list some proteins which have the same functions with IPO5. You can find most of the proteins on our site.
|GTPase inhibitor activity||GPS1; ARL2; UBE4A; CPEB2; RHOH; SLIT2; RTKN; GPS2; CDC42SE1; TNK2|
|Ran GTPase binding||IPO4; TNPO2; XPOT; XPO6; TNPO1; DPY19L2; KPNB1; IPO13; XPO1; CSE1L|
|nuclear localization sequence binding||TNPO1; IPO13; NFKBIA; KPNA3; TNPO2; KPNA1; NUP214; IPO5; KPNB3; IPO4|
|poly(A) RNA binding||NSUN5; RPS24; NQO1; PPP1R2P9; LSM2; SLC25A5; TWF2; RRP9; NAT10; DIMT1L|
|protein binding||RIMS2; HNRNPH1; SIL1; INSIG1; ADORA1; ZIC3; HFE; ANKRD49; PFN1; TGFB3|
|protein transporter activity||RAP1A; KPNA2; XPO1; RAMP2; KPNB3; KPNA1; DSCR3; SNUPN; RANBP6; USO1|
IPO5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IPO5 here. Most of them are supplied by our site. Hope this information will be useful for your research of IPO5.
RPL7; GABARAP; GABARAPL2; GABARAPL1; p27958-pro_0000037576