irf2
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  • Official Full Name
  • interferon regulatory factor 2
  • Background
  • IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
  • Synonyms
  • IRF2; interferon regulatory factor 2; IRF-2;
Cat.#:IRF2-377HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF2 Protein, His-tagged
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Cat.#:IRF2-5044HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRF2 Protein, GST-tagged
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Cat.#:Irf2-378MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Irf2 Protein, His-tagged
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Cat.#:IRF2-28272THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF2, His-tagged
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Cat.#:IRF2-366HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interferon Regulatory Factor-2, His-tagged
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Cat.#:IRF2-725HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human IRF2 Protein, DDK-tagged
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Cat.#:IRF2-8297MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IRF2 Protein
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Cat.#:IRF2-2294RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IRF2 Protein, His-tagged
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Cat.#:IRF2-6750CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IRF2
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Cat.#:IRF2-1904ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IRF2
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Cat.#:IRF2-5167HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human IRF2 293 Cell Lysate
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Involved Pathway

IRF2 involved in several pathways and played different roles in them. We selected most pathways IRF2 participated on our site, such as Apoptosis, Cytokine Signaling in Immune system, Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
GZMC; NFKBIAA; BID; TNFRSFA; CASP4; PPP3CCB; PPP3CC; DIABLOB; LMNB1; Fasl
Cytokine Signaling in Immune system
LGALS9; IFIT10; PAQR3A; IL17RD; NUP35; TRIM6; JAK1; KPNA3; NRG3; SPTBN2
Factors involved in megakaryocyte development and platelet production
GATA1; MYB; RACGAP1; IRF2; CABLES2; HBD; HBBE3; DOCK9; DOCK7; MFN2
Hemostasis
MFN2; SERPINF2B; KCNMB2; APOER2; CLU; SCG3; IRF2A; MFN1; ITGB3A; CFHL4
Immune System
CTSK; Siglece; ALCAMB; KLRF1; UBE2E3; WASF3; ACTR1B; ASB18; ARIH1; TRIM29
Innate Immune System
BTR29; MYO9B; TLR6; ABI1B; HBL3; POLR3G; CD180; CRP; DDX41; IFI16
Interferon Signaling
GBP5; ARIH1; MX2; ARIH1L; IRF9; TRIM17; XAF1; IFIT10; TRIM31; GBP6
Interferon alpha/beta signaling
ISG20; MX2; USP18; BST2; IFI27; IFITM3; IRF9; XAF1; IFITM2; IFI35

Protein Function

IRF2 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF2 itself. We selected most functions IRF2 had, and list some proteins which have the same functions with IRF2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ETS2; ONECUT1; MTF1; SOX8; HOXD13; CXXC1A; TRNP1; TCF25; TSHZ3; HIST1H2AO
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein GATA3; CREB3L3; AEBP1; ZFY2; KAT2B; H2AFY; ZIK1; ARHGAP35; E4F1; HOXD8
Function protein binding
Related Protein ERCC6L; TMEM67; MIIP; TUBGCP4; PODXL2; ULK1; KRTAP5-9; RAB35; RTN4A; KCNH7
Function transcription factor activity, sequence-specific DNA binding
Related Protein POU4F1; HOMEZA; HLFA; HNF1A; SOX11A; NFIL3; AFF4; AHR1A; STAT2; ZFP260
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein TRPS1; GABPA; LEF1; PPARG; NHLH1; ELF5; ALX1; ALX4; FOXF1; RFX6

Interacting Protein

IRF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF2.
ATG7; PPP3CB; FOXK1; FOXK2; HSP90AB1; fliN; FKBP7; AP5Z1; HCFC1; PPP3CA; IRF2BP2; IRF2BP1; IRF2BPL; HCFC2

IRF2 Related Gene Family

Cytokines