irf7
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  • Official Full Name
  • interferon regulatory factor 7
  • Background
  • Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors. IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
  • Synonyms
  • IRF7; interferon regulatory factor 7; IRF7A; IRF-7H; OTTHUMP00000162886; IRF-7; OTTHUMP00000162887; OTTHUMP00000229433; OTTHUMP00000229434; interferon regulatory factor-7H
Cat.#:IRF7-896HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRF7 Protein, His-tagged
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Cat.#:IRF7-2300RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IRF7 Protein, His-tagged
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Cat.#:IRF7-6924CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IRF7
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Cat.#:IRF7-10946ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IRF7
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Cat.#:IRF7-5160HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRF7 293 Cell Lysate
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Involved Pathway

IRF7 involved in several pathways and played different roles in them. We selected most pathways IRF7 participated on our site, such as Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Toll-like receptor signaling pathway
TLR9; STAT1B; IFNA12; IL6; LBP; MAP2K2B; TLR1LB; TMED7-TICAM2; RAC1A; PIK3R3B
RIG-I-like receptor signaling pathway
Ifna15; MAP3K7; IFNW1; NFKBIB; MAPK14B; TBK1; IFNA16; TP-1; IFIH1; IFNA2
Cytosolic DNA-sensing pathway
IFNB; IRF7; POLR3C; CCL4; IL18; POLR1C; POLR3B; DDX58; IL6; MB21D1
Hepatitis C
OAS1; PPP2R2A; IFIT1; MAPK1; MAPK11; PPP2CA; AKT2; CLDN4; EIF2AK2; IFN-a
Hepatitis B
OSTN; SMAD3; CCNA2; CREB3L1; IFNA4; Fasl; YWHAZ; TLR3; CCNE2; STAT5A
Measles
CCND3; MSN; TRP53; FASLG; RAB9A; IL12A; TAB2; CLEC4M; IFNB1; CD46
Influenza A
MAPK3; MAPK1; Ifna15; NXF3; PRKCA; IFNA13; RAE1; RSAD2; PIK3CA; BLB1
Herpes simplex infection
TLR3; CSNK2A2; IFNG; HLA-A; PER1A; EEF1DA; SRSF2B; SRSF3; HLA-DQB1; HCFC1A
Viral carcinogenesis
NFKBIA; CCNE1; PIK3R1; MDM2; HIST1H2BC; BAD; PRKACG; HIST1H4M; MAPK3; GTF2A2

Protein Function

IRF7 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF7 itself. We selected most functions IRF7 had, and list some proteins which have the same functions with IRF7. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein LIN28B; MLXIPL; SMARCB1; HER1; MIER3; PAX1A; NR1D4B; ERCC6L; MXTX2; H1M
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein RUVBL2; GATA1; STAT5A; EGR1; TFAP2A; MAZ; WBP2; NR4A2; PAX8; GBX2
Function protein binding
Related Protein CXADR; PAX6; ARHGEF1; CAMTA2; KDR; PHLPP1; ITGAM; SUV39H2; GNB5; BAG5
Function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein FOSL1; ARNTL2; ATF3; FOSB; FOSL2; CLOCK; TFAP2A; CREB3; IRF7; BATF2

Interacting Protein

IRF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF7.
BICP0; ORF45; TBK1; AIP; LTN1; ARAF; IRAK1; TLK2

IRF7 Related Articles

Audet, J; Kobinger, GP; et al. Immune Evasion in Ebolavirus Infections. VIRAL IMMUNOLOGY 28:10-18(2015).
Thackray, LB; Shrestha, B; et al. Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection. JOURNAL OF VIROLOGY 88:11007-11021(2014).