|Official Full Name||interferon regulatory factor 7|
|Background||Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors. IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.|
|Synonyms||IRF7; interferon regulatory factor 7; IRF7A; IRF-7H; OTTHUMP00000162886; IRF-7; OTTHUMP00000162887; OTTHUMP00000229433; OTTHUMP00000229434; interferon regulatory factor-7H|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
IRF7 involved in several pathways and played different roles in them. We selected most pathways IRF7 participated on our site, such as Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Toll-like receptor signaling pathway||IFNA1; CD14; CASP8; CCL3L3; CXCL8B.3; TMED7-TICAM2; CCL5; IFNA10; MAPK12; MAPK3|
|RIG-I-like receptor signaling pathway||TBKBP1; ATG12; OTUD5A; TRAF3; DHX58; FADD; DDX3; MAPK12A; IKBKE; IFNA4|
|Cytosolic DNA-sensing pathway||IL33; AIM2; IFNA8; IFNA4; IFNA1; IFNA13; IFNA7; POLR2K; ZBP1; IFI202B|
|Hepatitis C||IRF1; IFNAR1; CLDN3; SOCS3; CLDN5; OAS2; NR1H3; TLR3; TP53; TBK1|
|Hepatitis B||TRP53; GRB2; STAT5B; VDAC3; ELK1; NFATC4; DDX3X; IFNA12; PTK2B; MAPK1|
|Measles||IFNB1; TNFRSF10B; IRAK4; OAS1A; MX1; EIF2AK1; IL1B; FAS; CCND2; MAVS|
|Influenza A||PRSS2; HNRNPUL1; TMPRSS2; TNF; FASLG; TBK1; PIK3CA; IL6; PIK3R1; IFNA8|
|Herpes simplex infection||IKBKG; PVRL1B; POU2F3; IFNAR1; HLA-DQA2; Ifna15; SOCS3; SRSF1B; FOS; JAK2A|
|Viral carcinogenesis||CCNE1; ATF4; HLA-B; HDAC11; DLG1; RHOA; CCND2; ATP6V0D1; PRKACG; YWHAH|
IRF7 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF7 itself. We selected most functions IRF7 had, and list some proteins which have the same functions with IRF7. You can find most of the proteins on our site.
|DNA binding||H1FNT; ZNF557; ZFP689; HIST1H2AB; PRM3; POLR2H; ZIM2; HOXB1; ZNF136; CHD9|
|RNA polymerase II core promoter sequence-specific DNA binding||SUZ12; TBR1; FOS; TCF7L2; HOXB3; PAX8; STAT6; EGR1; H2AFZ; TRP53|
|protein binding||RNMT; SLC25A5; RIPPLY3; ZNF317; EIF4A2; RPS10; MPDU1; MAPK15; OBFC1; NUF2|
|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding||FOSB; FOSL2; SREBF1; MSX2; FOSL1; CLOCK; ARNTL; RBPJA; IRF7; RBPJB|
IRF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF7.
BICP0; ORF45; TBK1; AIP; LTN1; ARAF; IRAK1; TLK2