IRF7 Protein, interferon regulatory factor 7

IRF7

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IRF7

Official Full Name interferon regulatory factor 7
Background Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors. IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
Synonyms IRF7; interferon regulatory factor 7; IRF7A; IRF-7H; OTTHUMP00000162886; IRF-7; OTTHUMP00000162887; OTTHUMP00000229433; OTTHUMP00000229434; interferon regulatory factor-7H
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRF7-5160HCL Recombinant Human IRF7 293 Cell Lysate HEK293 N/A
    Human IRF7-896H Recombinant Human IRF7 Protein, His-tagged E.coli His
    Rhesus Macaque IRF7-2300R Recombinant Rhesus monkey IRF7 Protein, His-tagged Mammalian Cell His
    Chicken IRF7-6924C Recombinant Chicken IRF7 Mammalian Cell His
    Zebrafish IRF7-10946Z Recombinant Zebrafish IRF7 Mammalian Cell His

    IRF7 involved in several pathways and played different roles in them. We selected most pathways IRF7 participated on our site, such as Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Toll-like receptor signaling pathway IFNA1; CD14; CASP8; CCL3L3; CXCL8B.3; TMED7-TICAM2; CCL5; IFNA10; MAPK12; MAPK3
    RIG-I-like receptor signaling pathway TBKBP1; ATG12; OTUD5A; TRAF3; DHX58; FADD; DDX3; MAPK12A; IKBKE; IFNA4
    Cytosolic DNA-sensing pathway IL33; AIM2; IFNA8; IFNA4; IFNA1; IFNA13; IFNA7; POLR2K; ZBP1; IFI202B
    Hepatitis C IRF1; IFNAR1; CLDN3; SOCS3; CLDN5; OAS2; NR1H3; TLR3; TP53; TBK1
    Hepatitis B TRP53; GRB2; STAT5B; VDAC3; ELK1; NFATC4; DDX3X; IFNA12; PTK2B; MAPK1
    Measles IFNB1; TNFRSF10B; IRAK4; OAS1A; MX1; EIF2AK1; IL1B; FAS; CCND2; MAVS
    Influenza A PRSS2; HNRNPUL1; TMPRSS2; TNF; FASLG; TBK1; PIK3CA; IL6; PIK3R1; IFNA8
    Herpes simplex infection IKBKG; PVRL1B; POU2F3; IFNAR1; HLA-DQA2; Ifna15; SOCS3; SRSF1B; FOS; JAK2A
    Viral carcinogenesis CCNE1; ATF4; HLA-B; HDAC11; DLG1; RHOA; CCND2; ATP6V0D1; PRKACG; YWHAH

    IRF7 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF7 itself. We selected most functions IRF7 had, and list some proteins which have the same functions with IRF7. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding H1FNT; ZNF557; ZFP689; HIST1H2AB; PRM3; POLR2H; ZIM2; HOXB1; ZNF136; CHD9
    RNA polymerase II core promoter sequence-specific DNA binding SUZ12; TBR1; FOS; TCF7L2; HOXB3; PAX8; STAT6; EGR1; H2AFZ; TRP53
    protein binding RNMT; SLC25A5; RIPPLY3; ZNF317; EIF4A2; RPS10; MPDU1; MAPK15; OBFC1; NUF2
    transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding FOSB; FOSL2; SREBF1; MSX2; FOSL1; CLOCK; ARNTL; RBPJA; IRF7; RBPJB

    IRF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF7.

    BICP0; ORF45; TBK1; AIP; LTN1; ARAF; IRAK1; TLK2

    Audet, J; Kobinger, GP; et al. Immune Evasion in Ebolavirus Infections. VIRAL IMMUNOLOGY 28:10-18(2015).
    Thackray, LB; Shrestha, B; et al. Interferon Regulatory Factor 5-Dependent Immune Responses in the Draining Lymph Node Protect against West Nile Virus Infection. JOURNAL OF VIROLOGY 88:11007-11021(2014).

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