ISG20
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Official Full Name
interferon stimulated exonuclease gene 20kDa
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Overview
Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene. -
Synonyms
ISG20; interferon stimulated exonuclease gene 20kDa; interferon stimulated gene (20kD); interferon-stimulated gene 20 kDa protein; CD25; HEM45; Estrogen regulated transcript 45 protein; Interferon stimulated gene 20 kDa protein; Promyelocytic leukemia nuclear body associated protein; OTTHUMP00000192918; estrogen-regulated transcript 45 protein; promyelocytic leukemia nuclear body-associated protein ISG20;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- Human Cells
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ISG20 Related Gene Family
ISG20 involved in several pathways and played different roles in them. We selected most pathways ISG20 participated on our site, such as Cytokine Signaling in Immune system, Immune System, Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ISG20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | TRIM14;GBP5;EDAR;DUSP4;EIF4E;FRS2A;SPTA1;IFIT3;GHRB |
| Immune System | BTR18;FCN2;ADAR;OSBPL1A;CLEC4D;LTF;CRTAM;SOCS3A;RCA2.1 |
| Interferon Signaling | IFIT2;TRIM2;FCGR1B;TRIM22;TRIM29;IFIT14;ISG20;TRIM45;GBP5 |
| Interferon alpha/beta signaling | USP18;IFITM2;GBP2;IFI6;IRF2;XAF1;IFITM3;SAMHD1;IFI35 |
ISG20 has several biochemical functions, for example, 3-5-exoribonuclease activity, U1 snRNA binding, U2 snRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ISG20 itself. We selected most functions ISG20 had, and list some proteins which have the same functions with ISG20. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-5-exoribonuclease activity | ISG20;EXOSC4;C16orf57;USB1;PNPT1;ERI2;CNOT8;ERI1;SMFN |
| U1 snRNA binding | SNRNP70;SNRPA;ISG20;PRPF8 |
| U2 snRNA binding | ISG20;PRPF8;TROVE2;SNRPA1 |
| U3 snoRNA binding | NHP2L1;ISG20;DIEXF |
| exonuclease activity | EXOSC9;REXO1L1;DOM3Z;REXO4;FEN1;MEIOB;REX1;EXO1;ISG20L2 |
| exoribonuclease II activity | |
| metal ion binding | SETDB1B;ASXL2;PXNA;CYP2AA7;COL2A1;WBSCR17;KLF9;NRP2;ZFP574 |
| single-stranded DNA 3-5 exodeoxyribonuclease activity | ISG20;MEIOB;DEM1 |
ISG20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISG20 here. Most of them are supplied by our site. Hope this information will be useful for your research of ISG20.
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