ITGA7 Protein, integrin, alpha 7


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Official Full Name integrin, alpha 7
Background The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Synonyms [a]7; alpha7; ITGA7; integrin, alpha 7; integrin alpha-7
    • Species :
    • Human
    • Rat
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGA7-28842TH Recombinant Human ITGA7 Wheat Germ N/A
    Human ITGA7-4994H Recombinant Human ITGA7 Protein, GST-tagged Wheat Germ GST
    Rat ITGA7-3112R Recombinant Rat ITGA7 Protein Mammalian Cell His

    ITGA7 involved in several pathways and played different roles in them. We selected most pathways ITGA7 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway FGF5; CRTC2; PPP2R3C; TNN; TCL1; IFNAR1; IFNA6; IFNAR2; CREB3L3; GNB1
    Focal adhesion PDGFD; ITGA5; PARVG; RHOAB; COL24A1; MYL2B; GRB2; COL1A1B; LAMB2; CHAD
    ECM-receptor interaction SPP1; COL4A6; COL6A5; THBS2; FN1; ITGB5; GP6; LAMB4; COL6A1; COL4A5
    Regulation of actin cytoskeleton PAK2A; ITGA6B; ARPC5B; PIK3R1; ITGB1A; MYH10; FGF12; SCINLA; PFN2; ARPC5LB
    Hypertrophic cardiomyopathy (HCM) CACNG4; ITGA4; CACNG6; TNNC1; IGF1; ACTC1; PRKAB2; CACNB4; ITGA9; ITGA7
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGA10; ITGB6; CACNA2D4; ITGA1; ITGB1; CACNA2D3; ITGB5; ATP2A2; DSC2; SGCD
    Dilated cardiomyopathy MYBPC3; PRKACB; CACNG6; ITGA8; ITGA5; ITGA4; TPM2; ITGA10; MYL2; ITGB6

    ITGA7 has several biochemical functions, for example, laminin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA7 itself. We selected most functions ITGA7 had, and list some proteins which have the same functions with ITGA7. You can find most of the proteins on our site.

    Function Related Protein
    laminin binding RPSA; LYPD3; ITGB1; ITGA3; BCAM; GPC1; LRRC15; TINAGL1; AGRN; LGALS2A
    metal ion binding CYBRD1; TRAF4A; COL18A1; A3GALT2; ITGB1BP3; LFNG; PRKCHA; DBR1; ZNF471; ZC3H13
    protein binding TSHZ3; OSBPL1A; ASUN; HSPBP1; CTH; DDX6; MED8; ORAI2; NONO; SPATA22

    ITGA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA7.


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