itgax
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  • Official Full Name
  • integrin, alpha X (complement component 3 receptor 4 subunit)
  • Background
  • This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ITGAX; integrin, alpha X (complement component 3 receptor 4 subunit); CD11C; SLEB6
Cat.#:ITGAX-2812MTag:His/Myc
Source (Host):BaculovirusSpecies:Mouse
Product nameRecombinant Mouse ITGAX Protein (20-1116 aa), His-MBP-tagged
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Cat.#:ITGAX-4987HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGAX Protein, GST-tagged
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Cat.#:ITGAX-1553HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGAX protein, His-tagged
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Cat.#:ITGAX-266HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ITGAX
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Cat.#:ITGAX-4119HTag:Flag/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGAX, flag & His tagged
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Cat.#:Itgax-1554MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itgax protein, His & GST-tagged
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Cat.#:ITGAX & ITGB2-1875HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGAX & ITGB2 cell lysate
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Involved Pathway

ITGAX involved in several pathways and played different roles in them. We selected most pathways ITGAX participated on our site, such as Regulation of actin cytoskeleton, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGAX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Regulation of actin cytoskeleton
ITGB1B.2; FGF22; FGFR1A; RAF1; ITGAE; FGD1; MAPK6; MYLK; MAP2K1; EGFRA
Tuberculosis
NFYC; TGFB1; MAPK3; NFYB; ATP6AP1; Casp3; PPP3R2; IFNA2; IL10RB; ATP6V0A1

Protein Function

ITGAX has several biochemical functions, for example, metal ion binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGAX itself. We selected most functions ITGAX had, and list some proteins which have the same functions with ITGAX. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein ZFAT; COQ7; ITGA9; ACLYA; ZNF189; LHX1B; ZBTB8A; UNC13C; VAV1; ZNF319
Function protein binding
Related Protein FAM184A; ZNF224; UCP3; PSMC6; HMGB4; PSIP1; MAP2K4; KRTAP12-2; RYR1; KLF17
Function receptor activity
Related Protein LILRB3; ROBO4; NPC1; PVRL3; CD160; PROCR; VMN1R46; PLXNA1; TREM1; THBD

Interacting Protein

ITGAX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGAX here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGAX.
ITGB2; pepT

ITGAX Related Articles

Immig, K; Gericke, M; et al. CD11c-Positive Cells from Brain, Spleen, Lung, and Liver Exhibit Site-Specific Immune Phenotypes and Plastically Adapt to New Environments. GLIA 63:611-625(2015).
Williams, KA; Lee, M; et al. A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes. PLOS GENETICS 10:-(2014).