Recombinant Full Length Human ITGAD Protein, C-Flag-tagged

• Cat.No.: ITGAD-1941HFL
• Product Overview: Recombinant Full Length Human ITGAD Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 124.9 kDa
• AA Sequence: MTFGTVLLLSVLASYHGFNLDVEEP TIFQEDAGGFGQSVVQFGGSRLVVG APLEVVAANQTGRLYDCAAA TGMCQPIPLHIRPEAVNMSLGLTLA ASTNGSRLLACGPTLHRVCGENSYS KGSCLLLGSRWEIIQTVPDA TPECPHQEMDIVFLIDGSGSIDQND FNQMKGFVQAVMGQFEGTDTLFALM QYSNLLKIHFTFTQFRTSPS QQSLVDPIVQLKGLTFTATGILTVV TQLFHHKNGARKSAKKILIVITDGQ KYKDPLEYSDVIPQAEKAGI IRYAIGVGHAFQGPTARQELNTISS APPQDHVFKVDNFAALGSIQKQLQE KIYAVEGTQSRASSSFQHEM SQEGFSTALTMDGLFLGAVGSFSWS GGAFLYPPNMSPTFINMSQENVDMR DSYLGYSTELALWKGVQNLV LGAPRYQHTGKAVIFTQVSRQWRKK AEVTGTQIGSYFGASLCSVDVDSDG STDLILIGAPHYYEQTRGGQ VSVCPLPRGRVQWQCDAVLRGEQGH PWGRFGAALTVLGDVNEDKLIDVAI GAPGEQENRGAVYLFHGASE SGISPSHSQRIASSQLSPRLQYFGQ ALSGGQDLTQDGLMDLAVGARGQVL LLRSLPVLKVGVAMRFSPVE VAKAVYRCWEEKPSALEAGDATVCL TIQKSSLDQLGDIQSSVRFDLALDP GRLTSRAIFNETKNPTLTRR KTLGLGIHCETLKLLLPDCVEDVVS PIILHLNFSLVREPIPSPQNLRPVL AVGSQDLFTASLPFEKNCGQ DGLCEGDLGVTLSFSGLQTLTVGSS LELNVIVTVWNAGEDSYGTVVSLYY PAGLSHRRVSGAQKQPHQSA LRLACETVPTEDEGLRSSRCSVNHP IFHEGSNGTFIVTFDVSYKATLGDR MLMRASASSENNKASSSKAT FQLELPVKYAVYTMISRQEESTKYF NFATSDEKKMKEAEHRYRVNNLSQR DLAISINFWVPVLLNGVAVW DVVMEAPSQSLPCVSERKPPQHSDF LTQISRSPMLDCSIADCLQFRCDVP SFSVQEELDFTLKGNLSFGW VRETLQKKVLVVSVAEITFDTSVYS QLPGQEAFMRAQMEMVLEEDEVYNA IPIIMGSSVGALLLLALITA TLYKLGFFKRHYKEMLEDKPEDTAT FSGDDFSCVAPNVPLS TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Regulation of actin cytoskeleton

Gene Information

• Gene Name: ITGAD integrin subunit alpha D [ Homo sapiens (human) ]
• Official Symbol: ITGAD
• Synonyms: ADB2; CD11D
• Gene ID: 3681
• mRNA Refseq: NM_005353.3
• Protein Refseq: NP_005344.2
• MIM: 602453
• UniProt ID: Q13349