itpr2
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  • Official Full Name
  • inositol 1,4,5-trisphosphate receptor, type 2
  • Synonyms
  • ITPR2; inositol 1,4,5-trisphosphate receptor, type 2; inositol 1,4,5 triphosphate receptor, type 2; inositol 1,4,5-trisphosphate receptor type 2; IP3R2; 4; 5-trisphosphate receptor; Inositol 1 4 5 trisphosphate receptor type 2; Inositol 145 trisphosphate receptor type 2; InsP3 R2; InsP3R2; IP3 R2; IP3 receptor isoform 2; IP3R 2; ITPR 2; ITPR2_HUMAN; Type 2 inositol 1 4 5 trisphosphate receptor; Type 2 inositol 1; Type 2 inositol 145 trisphosphate receptor; Type 2 InsP3 receptor; IP3 receptor; inositol 1,4,5-triphosphate receptor, type 2; type 2 inositol 1,4,5-trisphosphate receptor
Cat.#:ITPR2-463HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ITPR2
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Cat.#:ITPR2-3126RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ITPR2 Protein
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Involved Pathway

ITPR2 involved in several pathways and played different roles in them. We selected most pathways ITPR2 participated on our site, such as Adaptive Immune System, Aldosterone synthesis and secretion, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
KLHL20; KIF3C; CLEC2B; NRG4; KLRG1; AP2B1; ACTR1A; AGO3; MOV10; ITGB1B.1
Aldosterone synthesis and secretion
ORAI1; HSD3B5; CYP21A1; AGTR1B; CAMK1D; PLCB4; PRKD3; NPR1; ATF1; CYP11B2
Alzheimers disease
NDUFA1; NDUFA10; CALM2; mt-Atp8; CASP7; GRIN2A; CALM3; ATP5G1; ATP5H; PPP3R2
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
AHCYL1; BLK; PIK3AP1; IGLC2; ITPR2; IGKC; IGKV1-5; AKR1C1; SRMS; STIM1B
B Cell Receptor Signaling Pathway
CD22; ACTR2; PLEKHA1; MALT1; RAF1; ARPC5; NFKBIA; CDK6; cgr2b; LCP2A
Beta-catenin independent WNT signaling
AP2M1; RYK; AP2A1; ROR2; PRICKLE1; CLTA; AP2S1; DVL3; MOV10; PRICKLE1B
C-type lectin receptors (CLRs)
MALT1; CREBBP; TAB1; CLEC4A; IL1B2; CASP8L1; CLEC4D; UBE2V1; AHCYL1; CLEC6A

Protein Function

ITPR2 has several biochemical functions, for example, calcium ion transmembrane transporter activity, inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity, phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR2 itself. We selected most functions ITPR2 had, and list some proteins which have the same functions with ITPR2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion transmembrane transporter activity
Related Protein ITPR2
Function inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Related Protein ITPR3; AKR1C1; ITPR2; ITPR1
Function phosphatidylinositol binding
Related Protein SH3PXD2AA; ITPR2; SNX17; WDR35; SNX8; SNX33; SNX15; TNFAIP8L3; SEPT12; PXK

Interacting Protein

ITPR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR2.
TRPC4; q81ye8_bacan; MYH9; CAPZA2; NUP107; Lima1; Myo1c; Sumo3

ITPR2 Related Articles

Zhang, ZJ; Tian, JL; et al. The Analysis of Expression of CCK and IP3 Receptors in Gallstones Patients with Type 2 Diabetes Mellitus. HEPATO-GASTROENTEROLOGY 61:2173-2176(2014).
Wang, JB; Wang, DL; et al. Tumor necrosis factor-alpha-induced reduction of glomerular filtration rate in rats with fulminant hepatic failure. LABORATORY INVESTIGATION 94:740-751(2014).