kars
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  • Official Full Name
  • lysyl-tRNA synthetase
  • Background
  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • KARS; lysyl-tRNA synthetase; lysine--tRNA ligase; KARS2; lysine tRNA ligase; lysRS; KRS; CMTRIB; KIAA0070
Cat.#:KARS-1010HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KARS, His-tagged
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Cat.#:KARS-29008THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KARS, His-tagged
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Cat.#:KARS-8215HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KARS protein, His & T7-tagged
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Cat.#:KARS-2338RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KARS Protein, His-tagged
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Cat.#:KARS-2296CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KARS
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Cat.#:KARS-527ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KARS
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Cat.#:KARS-5090HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KARS 293 Cell Lysate
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Involved Pathway

KARS involved in several pathways and played different roles in them. We selected most pathways KARS participated on our site, such as Aminoacyl-tRNA biosynthesis, Cytosolic tRNA aminoacylation, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with KARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aminoacyl-tRNA biosynthesis
WARS2; EPRS; SARS; RARS; SEPSECS; MARS; DARS2; LARS; MTFMT; AARS
Cytosolic tRNA aminoacylation
MADD; AARS; EEF1E1; AIMP2; KARS; FARSB; DARS; AIMP1
Gene Expression
SUGP1; ZNF202; KARS; HBXIP; LRPPRC; HENMT1; CDK8; ZNF554; PAPOLA; ZNF785
Mitochondrial tRNA aminoacylation
FARS2; WARS2; KARS; EARS2
tRNA Aminoacylation
EEF1E1; KARS; AARS; FARSB; DARS; MADD; AIMP2; AIMP1; FARS2; WARS2

Protein Function

KARS has several biochemical functions, for example, ATP binding, amino acid binding, lysine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KARS itself. We selected most functions KARS had, and list some proteins which have the same functions with KARS. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein XRCC5; FYN; P2RX5; TTLL1; ATAD1; EIF2AK2; ABCB9; NSF; ERCC6L; PIP5K1B
Function amino acid binding
Related Protein TH; DDAH1; TPH1B; AARS; KARS; TDO2; GOT2; DDC; AARS2; ASS1
Function lysine-tRNA ligase activity
Related Protein KARS
Function metal ion binding
Related Protein ZNF713; RPE; PCK2; GTSF1L; FXC1; MOB3A; CA4B; ACY1; NRP1A; ZNF182
Function protein binding
Related Protein PROL1; EIF4A2; ACTL7A; CLK3; SBNO2; KIF1C; POC5; HBP1; HSCB; FBXO17
Function tRNA binding
Related Protein DARS2; MARS; ALKBH8; AIMP1; CTU1; TRMT1L; XPO5; TRMT1; PSTK; AARS2

Interacting Protein

KARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KARS here. Most of them are supplied by our site. Hope this information will be useful for your research of KARS.
AIMP2; RPSA; gag; LAMB1; EPRS; IKBKE; TANK; FRS3; DYSF; GAPDH

KARS Related Articles

Hause, RJ; Stark, AL; et al. Identification and Validation of Genetic Variants that Influence Transcription Factor and Cell Signaling Protein Levels. AMERICAN JOURNAL OF HUMAN GENETICS 95:194-208(2014).
Ergunay, K; Gunay, F; et al. Serological, Molecular and Entomological Surveillance Demonstrates Widespread Circulation of West Nile Virus in Turkey. PLOS NEGLECTED TROPICAL DISEASES 8:-(2014).