kcna3
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  • Official Full Name
  • potassium voltage-gated channel, shaker-related subfamily, member 3
  • Background
  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
  • Synonyms
  • KCNA3; potassium voltage-gated channel, shaker-related subfamily, member 3; potassium voltage-gated channel subfamily A member 3; HLK3; HPCN3; Kv1.3; MK3; potassium channel 3; type n potassium channel; voltage-gated K(+) channel HuKIII; voltage-gated potassium channel protein Kv1.3; voltage-gated potassium channel subunit Kv1.3; HGK5; PCN3; HUKIII
Cat.#:KCNA3-29890THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human KCNA3
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Cat.#:KCNA3-8473MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNA3 Protein
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Cat.#:KCNA3-3166RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNA3 Protein
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Cat.#:KCNA3-2345RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KCNA3 Protein, His-tagged
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Cat.#:KCNA3-2242CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KCNA3
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Involved Pathway

KCNA3 involved in several pathways and played different roles in them. We selected most pathways KCNA3 participated on our site, such as ATF-2 transcription factor network, ATF4 activates genes, ATF6-alpha activates chaperone genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ATF-2 transcription factor network
KCNA3; CREB1; KAT5; CDK4; DUSP10; JUNB; POU2F1; DDIT3; DUSP5; HRK
ATF4 activates genes
EXOSC8; DCP2; DDIT3; KCNA3
ATF6-alpha activates chaperone genes
KCNA3; DDIT3
ATF6-alpha activates chaperones
KCNA3; DDIT3; YY2
Adipogenesis
EPAS1B; PIANP; GATA2A; MBNL1; HMGA1-RS1; CISD1; KLF6; NDN; HMGA1; MEF2B
MAPK signaling pathway
TRAF2; GNG12; HRASB; C11orf52; NTRK1; CDC25B; CACNB2A; HRASA; FGF22; MAPK11
Metabolism of proteins
TRAPPC2L; MAN1A2; EXOC1; ST8SIA2; EXOC8; MUC20; SFTPC; PAPPAB; RNF2; TUBA1B
Non-alcoholic fatty liver disease (NAFLD)
COX7A2; UQCRC2; MLXIPL; Fasl; PRKAG3; AKT1; PIK3R1; Casp3; PIK3CD; NDUFA9

Protein Function

KCNA3 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, cAMP response element binding protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNA3 itself. We selected most functions KCNA3 had, and list some proteins which have the same functions with KCNA3. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein NKX6.1; APITD1; ZNF454; ABI2; DNA2; ZNF580; HOXA11B; ASXL1; RBPJ; C1D
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein HNRNPK; FEZF2; CREB3L2; GABPA; IRF1; BCL11B; ZNF695; KCNIP3; OVOL1; NKX2-5
Function cAMP response element binding protein binding
Related Protein CRTC3; ATF2; CRTC1; CRTC1A; DDIT3; CREB3; CREM; CRTC2; KCNA3; DAPK3
Function leucine zipper domain binding
Related Protein ATF4; PMF1; PAWR; DAPK3; KCNA3; ERC1; CRX; DDIT3; NRL; MKL1
Function protein binding
Related Protein TMEM59; TNFSF14; SIGIRR; RAB43; DNAIC2; FAM162A; NDFIP2; AUP1; NUDT22; KIF2C
Function protein heterodimerization activity
Related Protein HIST1H4H; HIST2H2L; HEYL; MAFGB; TWIST1; SIM2; BIK; SRY; HIST2H2AC; VEGFA
Function NOT protein homodimerization activity
Related Protein MLXIPL; NUDT16L1; MSH3; DDIT3; MSH6; EXT2; MECOM; MYO9B; KCNA3
Function transcription corepressor activity
Related Protein PEX14; DDIT3; LHX1; ERF; THRB; DRAP1; YWHAB; C1QBP; AEBP1; CBFA2T3
Function transcription factor activity, sequence-specific DNA binding
Related Protein PRDM1A; HOXB4A; ZFP2; ZFY2; ZNF445; PBX1A; ZNF238; DBPB; HINFP; HOXC4
Function transcription factor binding
Related Protein TP73; BCL3; PRKDC; SORBS3; KDM1A; SIX2; HMGB1; NFYC; H2-AB1; HDAC9
Function transcription regulatory region DNA binding
Related Protein TCF7; SOX7; KCNA3; SFPQ; GABPA; ZBTB14; Arid4b; ATMIN; REST; SERPINB1A
Function transcription regulatory region sequence-specific DNA binding
Related Protein SIN3A; NFE2L3; GATA3; NFKB1; ZNF658; CRY2; BACH1B; NR5A1A; NR5A1B; ARNTL1A
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein EPAS1; ZFP292; CEBPZ; CEBPG; DBP; FOXL2; SPI1; ZFP750; NRF1; TRP63

Interacting Protein

KCNA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNA3.
Dlg4

KCNA3 Related Articles

Almilaji, A; Honisch, S; et al. Regulation of the Voltage Gated K+ Channel K-v1.3 by Recombinant Human Klotho Protein. KIDNEY & BLOOD PRESSURE RESEARCH 39:609-622(2014).