kcnh2
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  • Official Full Name
  • Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2
  • Background
  • This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.
  • Synonyms
  • KCNH2; potassium voltage-gated channel, subfamily H (eag-related), member 2; ERG1; HERG; LQT2; SQT1; HERG1; Kv11.1; potassium voltage-gated channel subfamily H member 2; ERG-1; H-ERG; hERG-1; eag homolog; eag-related protein 1; ether-a-go-go-related protein 1; ether-a-go-go-related gene potassium channel 1; voltage-gated potassium channel subunit Kv11.1; ether-a-go-go-related potassium channel protein
Cat.#:KCNH2-3183RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNH2 Protein
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Cat.#:KCNH2-5059HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human KCNH2 293 Cell Lysate
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Involved Pathway

KCNH2 involved in several pathways and played different roles in them. We selected most pathways KCNH2 participated on our site, such as Neuronal System, Potassium Channels, SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuronal System
AKAP5; KCNA2B; KCNAB1; KCNAB2; SLC6A12; DDX1; KCNJ1B; KCNK4; KCNS3A; SLC1A7B
Potassium Channels
KCNJ1A.5; KCNH2; KCNC1; KCNK13A; KCNN3; KCNQ3; KCNS2; KCNJ1A.4; KCNF1; KCNH6A
SIDS Susceptibility Pathways
TAC1; PKNOX1; POU3F2; MAZ; CDCA7L; CTCF; KCNQ1; SCN3B; POU2F2; CC2D1A
Voltage gated Potassium channels
KCNS3; KCNG1; KCNAB1; KCNC4; KCNH6A; KCNA6; KCNH1; KCNAB2B; KCNH5A; KCNA2

Protein Function

KCNH2 has several biochemical functions, for example, C3HC4-type RING finger domain binding, delayed rectifier potassium channel activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNH2 itself. We selected most functions KCNH2 had, and list some proteins which have the same functions with KCNH2. You can find most of the proteins on our site.
Function
Related Protein
Function C3HC4-type RING finger domain binding
Related Protein HSPA8; KCNH2; PINK1; HSPA1B; DNAJA1; HSPA1A
Function delayed rectifier potassium channel activity
Related Protein KCNQ1; KCNV2B; KCNQ2A; KCNC4; KCNC3A; KCND1; KCNA2; KCNC1A; KCNA6; KCNA2B
Function identical protein binding
Related Protein LTBR; UAP1; SOD1; RIPK3; HGF; LEPR; LCK; SMURF2; PFKL; SUN2
Function inward rectifier potassium channel activity
Related Protein KCNK1; KCNJ1A.6; KCNJ12; KCNJ18; KCNJ1A.1; KCNJ1A.2; KCNJ4; KCNK6; KCNJ1; KCNJ16
Function phosphorelay sensor kinase activity
Related Protein KCNH5; KCNH8; KCNH5A; KCNH2; CASS4; KCNH1A; KCNH1; KCNH1B
Function protein binding
Related Protein PEX10; BTF3; CAMK2B; NUBP2; CAPNS2; DCPS; PTPRB; DYNC1LI1; FOSL1; ATXN3
Function protein homodimerization activity
Related Protein ATIC; SRGAP2A; CADM4; CD4; UGT1A6; VPS24; ANO2; HMGCS1; BHLHE40; GLA
Function scaffold protein binding
Related Protein KCNH2; CHRNA7; CASP8; CRIPT; NCK2; KRT5; KCNA5; KRT8; MAPK3; TREM2
Function ubiquitin protein ligase binding
Related Protein TCEB2; TRIM37; GABARAPL1; UBE2Z; SMAD3; IKBKG; TNFRSF14; WFS1; PDE4D; MOAP1
Function voltage-gated potassium channel activity
Related Protein KCND2; KCNH6A; KCNA4; CNGA2; KCNA6; KCNMA1; KCNC1; KCNE4; KCNQ2; CNGA5
Function contributes_to voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
Related Protein KCNH2; KCNE1L; KCNE1
Function voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Related Protein KCNQ1; KCNH2; KCNE2

Interacting Protein

KCNH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNH2.
CAV1; PASK; NDUFS6; ARHH; CDC73; GABARAP; MAP1LC3B

KCNH2 Related Articles

Kinoshita, K; Yamaguchi, Y; et al. A Novel Missense Mutation Causing a G487R Substitution in the S2-S3 Loop of Human ether-a-go-go-Related Gene Channel. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 23:1246-1253(2012).
Wulff, H; Castle, NA; et al. Voltage-gated potassium channels as therapeutic targets. NATURE REVIEWS DRUG DISCOVERY 8:982-1001(2009).