KCNH2
-
Official Full Name
Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2
-
Overview
This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. -
Synonyms
KCNH2; potassium voltage-gated channel, subfamily H (eag-related), member 2; ERG1; HERG; LQT2; SQT1; HERG1; Kv11.1; potassium voltage-gated channel subfamily H member 2; ERG-1; H-ERG; hERG-1; eag homolog; eag-related protein 1; ether-a-go-go-related protein 1; ether-a-go-go-related gene potassium channel 1; voltage-gated potassium channel subunit Kv11.1; ether-a-go-go-related potassium channel protein;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cavia porcellus (Guinea pig)
- Human
- Rat
- Sus scrofa (Pig)
- E.coli expression system
- HEK293
- Mammalian cell
- Mammalian Cell
- C
- 10×His
- eGFP
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- KCNH2 Related Articles
KCNH2 involved in several pathways and played different roles in them. We selected most pathways KCNH2 participated on our site, such as Neuronal System, Potassium Channels, SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Neuronal System | LIN7A;SNAP25B;ARL6IP5A;KCNA6;NSFA;SLC18A3A;NSFB;KCNN4;CHRND |
Potassium Channels | KCNJ1A.6;KCNAB3;KCNAB1A;KCNB2;KCNK2;KCNH6A;KCNK1B;KCNA6;KCNK4 |
SIDS Susceptibility Pathways | CTCF;EN1;KCNQ1;ASCL1;PKNOX1;CHRFAM7A;LMX1B;SNTA1;MAP2 |
Voltage gated Potassium channels | KCNAB3;KCNG4A;KCNS3A;KCNG1;KCND1;KCNH1B;KCNA1;KCNC4;KCNS2 |
KCNH2 has several biochemical functions, for example, C3HC4-type RING finger domain binding, delayed rectifier potassium channel activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNH2 itself. We selected most functions KCNH2 had, and list some proteins which have the same functions with KCNH2. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
C3HC4-type RING finger domain binding | DNAJA1;HSPA1A;KCNH2;HSPA8;PINK1;HSPA1B |
delayed rectifier potassium channel activity | KCNF1;KCNQ1;KCNA7;KCNC1A;KCNC4;KCNQ4;KCNE1;KCNS3A;KCNV2B |
identical protein binding | PCNA;LTBR;PRC1;RAF1;C1QL2;RUNX1T1;PRMT1;CBLL1;WAS |
inward rectifier potassium channel activity | KCNJ8;KCNJ18;KCNQ5;KCNJ1B;KCNJ1A.3;KCNJ1A.6;KCNJ16;KCNK1;KCNJ1A.1 |
phosphorelay sensor kinase activity | KCNH5;CASS4;KCNH5A;KCNH2;KCNH8;KCNH1;KCNH1A;KCNH1B |
protein binding | KRT6A;MAPK8;PCGF1;UBE2V2;WDYHV1;LOX;CPSF2;EYA3;ARHGEF40 |
protein homodimerization activity | CRYBA2;CAMK2A;PVRL3;HES1;ZNF174;BIRC5;SYT16;RPL7;FGFR1OP |
scaffold protein binding | KRT15;NLGN1;CHRNA7;P2RY1;KRT8;HOMER1;NLGN4Y;KCNA5;SHANK1 |
ubiquitin protein ligase binding | TRAF4;HERC2;UBE2K;FANCL;TUBA1B;MYOD1;OTUB1;CDKN1A;HSPA1A |
voltage-gated potassium channel activity | KCNG4A;KCNQ3;KCNAB2B;KCNH6A;KCNC1A;KCNA6;KCNMA1A;HCN2;KCNJ11 |
contributes_to voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization | KCNE1;KCNE1L;KCNH2 |
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization | KCNH2;KCNE2;KCNQ1 |
KCNH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNH2.
CAV1; PASK; NDUFS6; ARHH; CDC73; GABARAP; MAP1LC3B
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All KCNH2 Products
Required fields are marked with *
My Review for All KCNH2 Products
Required fields are marked with *