kcnj11
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  • Official Full Name
  • potassium inwardly-rectifying channel, subfamily J, member 11
  • Background
  • Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]
  • Synonyms
  • KCNJ11; potassium inwardly-rectifying channel, subfamily J, member 11; BIR; HHF2; PHHI; IKATP; TNDM3; KIR6.2; ATP-sensitive inward rectifier potassium channel 11; beta-cell inward rectifier subunit; inward rectifier K(+) channel Kir6.2; inwardly rectifying potassium channel KIR6.2; potassium channel inwardly rectifing subfamily J member 11; potassium channel, inwardly rectifying subfamily J member 11;
Cat.#:KCNJ11-29900THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human KCNJ11
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Cat.#:KCNJ11-498HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human KCNJ11
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Cat.#:KCNJ11-3196RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNJ11 Protein
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Cat.#:Kcnj11-3756RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Kcnj11, His-tagged
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Cat.#:KCNJ11-2358RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KCNJ11 Protein, His-tagged
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Cat.#:KCNJ11-3666ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KCNJ11
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Involved Pathway

KCNJ11 involved in several pathways and played different roles in them. We selected most pathways KCNJ11 participated on our site, such as ABC-family proteins mediated transport, ATP sensitive Potassium channels, FOXA2 and FOXA3 transcription factor networks, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ABC-family proteins mediated transport
ABCA7; ABCC2; ABCA8; APOA1B; KCNJ11; ABCG4B; CFTR; ABCF1; ABCB8; ABCE1
ATP sensitive Potassium channels
KCNJ8; ABCC9; KCNJ11
FOXA2 and FOXA3 transcription factor networks
CPT1A; FOXA1; FOXF1; DLK1; UCP2; CPT1C; CPT1B; TTR; KCNJ11; CEBPA
Insulin secretion
KCNMB2; VAMP2; GIP; CREB3L1; PRKACG; FXYD2; PLCB3; SLC2A2; ATP1A3; GNAQ
Integration of energy metabolism
KCNS3A; AKAP5; GNG13B; RAPGEF3; GNG13A; ARL2; MARCKSB; RAPGEF4; KCNJ11; SYT5
Inwardly rectifying K+ channels
KCNJ10; KCNJ1B; KCNJ1A.2; KCNJ11; KCNJ1A.3; GNGT2B; KCNJ1; ABCC9; KCNJ1A.4; KCNJ8
Metabolism
SLC25A2; CKBA; FTCD; OAZ2B; MED29; SLCO1B1; ATP5S; ACSF3; BSG; C20orf7
Neuronal System
KCNH2A; GRIP1; KCNA2; CPLX1; KCNN4; SLC6A11; KCNQ2; KCNK13A; KCNH6A; KCNC1

Protein Function

KCNJ11 has several biochemical functions, for example, ATP binding, ATP-activated inward rectifier potassium channel activity, NOT G-protein activated inward rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ11 itself. We selected most functions KCNJ11 had, and list some proteins which have the same functions with KCNJ11. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CLK4; SHPRH; CSNK2A1; ACTC1B; MYH8; DTYMK; UCKL1A; INSR; PMVK; ADCY9
Function ATP-activated inward rectifier potassium channel activity
Related Protein KCNJ1A.1; KCNJ1A.4; KCNJ11; KCNJ1A.6; KCNJ1; KCNJ10; KCNJ1A.3; KCNJ11L; KCNJ1B; KCNJ1A.5
Function NOT G-protein activated inward rectifier potassium channel activity
Related Protein KCNJ11; KCNJ11L; KCNJ8
Function ankyrin binding
Related Protein SLC8A1; KCNQ2; SCN5A; SLC4A1; KCTD6; RHAG; SPTBN1; KCNJ11; CDH1; FLNC
Function heat shock protein binding
Related Protein CDC37L1; DNAJA3; BCOR; PPID; HSPA6; HDAC2; DNAJA3B; IRAK1; DNAJA3A; DLST
Function ion channel binding
Related Protein S100A10; KCNJ11; CALM2; SLC14A2; BAK1; SRC; FYN; RIMS1; RYR2; PACS1
Function potassium ion binding
Related Protein PKMA; ATP1A1; KCNA4; SLC24A4; SLC24A5; PKMB; SLC24A1; PKM2; PDXK; PKM
Function protein C-terminus binding
Related Protein TRIM3; NCF2; MIF4GD; TAE1; CORO1A; ABL1; CITED1; ERCC1; KCNIP3; SDCBP
Function voltage-gated potassium channel activity
Related Protein KCNV2B; KCNQ2A; KCNAB3; KCNE3; KCNV2; KCNA1; CNGA1; KCNQ3; KCNC1; KCNH6A

Interacting Protein

KCNJ11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ11 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ11.
ABCC9; Kcnj11; ugpC

KCNJ11 Related Articles

Alves, C; Constanca, J; et al. A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 26:1163-1166(2013).
Irgens, HU; Molnes, J; et al. Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry. DIABETOLOGIA 56:1512-1519(2013).